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Hypoxia/Ischemia and the pH Paradox

  • Joseph C. LaManna
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 388)

Abstract

Hydrogen ions play an important role in cellular processes. There are intimate links between energy metabolism and the control of cell and tissue acid/base balance. Control of this balance is threatened or lost during severe hypoxia or ischemia. Re-establishment of pH balance must occur before the tissue can be considered to have returned to normal operating conditions. Because hydrogen ions influence so many reactions, the timing of renormalization can be crucial to the entire recovery process. Indeed, in many active tissues, too fast reversal of acidosis during recovery from severe hypoxia or ischemia appears to be detrimental to the overall recovery of homeostasis. That a tissue could restore function more rapidly if mild acidosis were maintained during the immediate post-stress recovery time has been referred to as the “pH paradox” (Currin et al., 1991), in analogy with the so-called “calcium paradox” that has been discussed primarily in the cardiovascular literature. In this paper we will review the changes that occur in pHi during hypoxia and ischemia in rat brain. We will explore the interrelationships of protons with metabolism, and we will propose a scheme for the interaction of protons in brain function. Finally, we will attempt to reach a conclusion concerning the applicability of the concept of pH paradox in brain.

Keywords

Severe Hypoxia Functional Capillary Density Calcium Paradox Lactic Acid Accumulation Anoxic Depolarization 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1996

Authors and Affiliations

  • Joseph C. LaManna
    • 1
  1. 1.Department of Neurology Scool of MedicineCase Western Reserve UniversityClevelandUSA

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