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Influence of the Treadmill Speed/Slope on Quadriceps Oxygenation During Dynamic Exercise

  • V. Quaresima
  • A. Pizzi
  • R. A. De Blasi
  • A. Ferrari
  • M. Ferrari
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 388)

Abstract

One of the main obstacles that has restricted “in vivo” studies of skeletal muscle metabolism during exercise has been the invasive nature of tissue biopsy and the high cost of phosphorus nuclear magnetic resonance equipment. Big research efforts have been recently focused on the development of non-invasive optical techniques to monitor tissue functions. Changes of cerebral and muscle oxy- and deoxy-hemoglobin ([Hb02], [Hb]) can be quantitated from near infrared spectroscopy (NIRS) measurements combining absorption and optical pathlength (Ferrari et al. 1992). NIRS has been extensively used in neuroscience to measure cerebral oxygenation, blood flow, and blood volume (Edwards et al. 1988; Wyatt et al. 1990). Some efforts have been focused also on skeletal muscle. In the last four years the aim of our group has been to explore NIRS capabilities for muscle functional monitoring. Pathlength changes in muscle have been measured on volunteers in different experimental conditions by time resolved spectroscopy (Ferrari et al. 1993) and phase modulation (Duncan et al. 1993). Muscle oxygen consumption (V02) can be measured by NIRS at rest and during isometric exercise by the application of arterial occlusion (Cheatle et al. 1991; De Blasi et al. 1993). We recently proposed a new method for the simultaneous measurement of forearm blood flow and V02 by inducing a venous occlusion (De Blasi et al. 1994).

Keywords

Near Infrared Spectroscopy Forearm Blood Flow Muscle Oxygenation Treadmill Speed Skeletal Muscle Metabolism 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Chance, B., Nioka, S., Kent, J., McCully, K., Fountain, M., Greenfeld, R., and Holtom, G., 1988, Time-resolved spectroscopy of hemoglobin and myoglobin in resting and ischemic muscle, Anal. Biochem. 174, 698–707.PubMedCrossRefGoogle Scholar
  2. Chance, B., Dait, M.T., Zhang, C, Hamaoka, T. and Hagerman, K., 1992, Recovery from exercise-induced desaturation in the quadriceps muscle of elite competitive rowers, Am. J. Physiol. 262:C766–C775.PubMedGoogle Scholar
  3. Cheatle, T.R., Potter, L.A., Cope, M., Delpy, T, Coleridge Smith, P.D., and Scurr J.H., 1991, Near-infrared spectroscopy in peripheral vascular disease, Brit. J. Surg. 78:405–408.PubMedCrossRefGoogle Scholar
  4. De Blasi, R.A., Conti, G., Mattia, C, Mega, A.M., Ferrari, M., and Gasparetto, A., 1992, Non-invasive evaluation of respiratory muscle oxygenation in mechanically ventilated patients by near infrared spectroscopy, Int. Care Med. 18:P5.CrossRefGoogle Scholar
  5. De Blasi, R.A., Cope, M., Elwell, C, Safoue, F., and Ferrari M., 1993, Non invasive measurement of human forearm oxygen consumption by near infrared spectroscopy, Eur. J. Appi. Physiol. 67:20–25.CrossRefGoogle Scholar
  6. De Blasi, R.A., Ferrari, M., Natali, A., Conti, G., Mega, A., and Gasparetto A., 1994, Non-invasive measurement of forearm blood flow and oxygen consumption by near infrared spectroscopy, J. Appi Physiol. 76:1388–1393.Google Scholar
  7. Duncan, A., Whitlock, TL., Cope, M., and Delpy, D.T., 1993, A multiwavelength, wideband, intensity modulated optical spectrometer for near infrared spectroscopy and imaging, Proc. SPIE 1888 248–257.CrossRefGoogle Scholar
  8. Edwards, A.D., Wyatt, J.S., Richardson, C.E., Delpy, D.T., Cope, M., and Reynolds, E.O.R. 1988, Cotside measurement of cerebral blood flow in ill newborn infants by near infrared spectroscopy, Lancet 2:770–771.PubMedCrossRefGoogle Scholar
  9. Ferrari, M., Wei, Q., Carraresi, L., De Blasi, R.A., and Zaccanti, G., 1992, Time-resolved spectroscopy of human forearm, J. Photochem. Photobiol. 16:141–153.CrossRefGoogle Scholar
  10. Ferrari, M., Wei, Q., De Blasi, R.A., Quaresima, V., and Zaccanti, G., 1993, Variability of human brain and muscle optical pathlength in different experimental conditions, Proc. SPIE 1888:466–472.CrossRefGoogle Scholar
  11. Hampson, N.B., and Piantadosi, C.A., 1988, Near infrared monitoring of human skeletal muscle oxygenation during forearm ischemia, J. Appi. Physiol. 64:2449–2457.Google Scholar
  12. Mancini, D.M., Ferraro, N., Nazzaro, D., Chance, B., and Wilson, J.R., 1991, Respiratory muscle deoxygenation during exercise in patients with heart failure demonstrated with near infrared spectroscopy, J. Am. Coll. Cardiol. 18:492–498.PubMedCrossRefGoogle Scholar
  13. Mancini, D.M., Wilson, J.R., Bolinger, L., Li, H., Kendrick, K., Chance, B., and Leigh, J.S., 1994, In vivo magnetic resonance spectroscopy measurement of deoxymyoglobin during exercise in patients with heart failure. Demonstration of abnormal muscle metabolism despite adequate oxygenation, Circulation 90:500–508.Google Scholar
  14. McCully, K.K., Halber, C, and Posner, J.D., 1994, Exercise-induced changes in oxygen saturation in the calf muscles of elderly subjects with peripheral vascular disease, J. Gerontol. 49:B128–B134.PubMedGoogle Scholar
  15. McCully, K.K., lotti, S., Kendrick, K., Wang, Z., Posner, J.D., Leigh, J., and Chance B., 1994, Simultaneous in vivo measurement of Hb02 saturation and PCr kinetics after exercise in normal humans, J. Appi. Physiol. 77:5–10.Google Scholar
  16. Wilson, J.R., Mancini, D.M., McCully, K., Ferraro, N., Lanoce, V., and Chance, B., 1989, Noninvasive detection of skeletal muscle underperfusion with near-infrared spectroscopy in patients with heart failure, Circulation 80:1668–1674.PubMedCrossRefGoogle Scholar
  17. Wyatt, J.S., Cope, M., Delpy, D.T., Richardson, C.E., Edwards, A.D., Wray, S., and Reynolds, E.O.R.,1990, Quantitation of cerebral blood volume in human infants by near-infrared spectroscopy, J. Appi. Physiol. 68:1086–1091.Google Scholar

Copyright information

© Plenum Press, New York 1996

Authors and Affiliations

  • V. Quaresima
    • 1
  • A. Pizzi
    • 2
  • R. A. De Blasi
    • 3
  • A. Ferrari
    • 4
  • M. Ferrari
    • 1
    • 5
  1. 1.Department of Biomedical Sciences and TechnologyUniversity of L’AquilaL’AquilaItaly
  2. 2.Centro di Recupero Funzionale Fondazione Pro Juventute Don C. GnocchiFirenzeItaly
  3. 3.Institute of AnesthesiologyI University of RomeItaly
  4. 4.Rehabilitation SectionScandiano HospitalItaly
  5. 5.Istituto Superiore SanitàRomeItaly

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