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Cerebral Oxygenation Changes During Motor and Somatosensory Stimulation in Humans, as Measured by Near-Infrared Spectroscopy

  • Hellmuth Obrig
  • Tilo Wolf
  • Claudia Döge
  • Jan Junge Hülsing
  • Ulrich Dirnagl
  • Arno Villringer
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 388)

Abstract

Functional cortical activation is coupled to changes of cerebral hemodynamics and metabolism. These changes have been used in positron emission tomography and recently developed functional magnetic resonance techniques to localize task-related cortical activation. Near-infrared spectroscopy has the potential to monitor changes of intracerebral blood oxygenation during functional activation (Villringer 1993, Hoshi 1993). We proceeded from a rather global, cognitive stimulus to experimental paradigms which entail a more localized cerebral activation and which have been examined by other functional techniques. In establishing a simple motor and a vibratory stimulus we sought a means to further examine the issue of coupling of neuronal function and cerbral hemodynamics. In recent experiments we were able to demonstrate that these stimulation models are useful to retrieve additional information about oxygenation dependent signal changes in functional MRI (Kleinschmidt 1994, Obrig 1994). As near-infrared spectroscopy has a good temporal resolution, we were also interested in the time course of local oxygenation changes.

Keywords

Stimulation Period Vibratory Stimulation Vibratory Stimulus Somatosensory Stimulation Motor Stimulation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1996

Authors and Affiliations

  • Hellmuth Obrig
    • 1
  • Tilo Wolf
    • 1
  • Claudia Döge
    • 1
  • Jan Junge Hülsing
    • 1
  • Ulrich Dirnagl
    • 1
  • Arno Villringer
    • 1
  1. 1.Department of NeurologyHumboldt-UniversityCharité BerlinGermany

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