Myocardial Oxygenation and Contractile Function During Graded Reduction of Coronary Flow

  • Eiichiro Imamura
  • Akira Kitabatake
  • Mamoru Tamura
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 388)


In the isolated perfused heart, several studies have shown that there is a linear relationship between coronary flow and myocardial contractile function (1–7). The severe reductions of coronary flow decreases high energy phosphate compounds and increases lactate production. In contrast, the mild reductions cause only reduction in contractile function but not high energy compounds (2,4,5,7,8). Under such conditions it is supposed that reduced energy consumption (oxygen demand) balances the reduced oxygen supply (4,6).


Coronary Flow Contractile Function Perfuse Heart Oxygen Dependence Coronary Flow Rate 
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Copyright information

© Plenum Press, New York 1996

Authors and Affiliations

  • Eiichiro Imamura
    • 1
    • 2
  • Akira Kitabatake
    • 2
  • Mamoru Tamura
    • 1
  1. 1.Research Institute for Electronic ScienceHokkaido UniversitySapporoJapan
  2. 2.Department of Cardiovascular MedicineHokkaido UniversitySapporoJapan

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