Myocardial Oxygenation and Contractile Function During Graded Reduction of Coronary Flow
In the isolated perfused heart, several studies have shown that there is a linear relationship between coronary flow and myocardial contractile function (1–7). The severe reductions of coronary flow decreases high energy phosphate compounds and increases lactate production. In contrast, the mild reductions cause only reduction in contractile function but not high energy compounds (2,4,5,7,8). Under such conditions it is supposed that reduced energy consumption (oxygen demand) balances the reduced oxygen supply (4,6).
KeywordsCoronary Flow Contractile Function Perfuse Heart Oxygen Dependence Coronary Flow Rate
Unable to display preview. Download preview PDF.
- 6.Downing, S.E., and Chen, V., 1990, Myocardial hibernation in the ischemic neonatal heart, Cir. Res. 66:763–772.Google Scholar
- 9.Araki, R., Tamura, M., and Yamazaki, I., 1983, The effect of intracellular oxygen concentration on lactate release, pyridine nucleotide reduction, and respiration rate in the rat cardiac tissue, Cir. Res. 53:448–455.Google Scholar
- 10.Fukuda, H., Yasuda, H., Shimokawa, S., and Tamura, M., 1988, The oxygen dependence of the energy state of cardiac tissue: 31P-NMR and optical measurement of myoglobin in perfused rat heart, Adv. Exp. Med. Biol. 248:567–573.Google Scholar