Plasma Mixing is Likely to Affect Capillary Oxygen Transport in Hard Working Rat Heart
The delivery of oxygen to tissue occurs primarily in the capillaries. Therefore a substantial part of the research on oxygen transport into the tissue has been directed towards oxygen release and transport in and around capillaries. The influence of the major determinants on this transport, such as diffusion coefficient, blood flow, reaction kinetics, has been well investigated. One of the possible influences on the oxygen transport in the capillaries was, seemingly, eliminated by Aroesty and Gross (1970). They investigated the effect of plasma mixing on oxygen transport in capillaries and showed that the net effect of mixing was negligible. The enhancement near the red blood cell (RBC) downstream of a small plasma volume was cancelled out near the upstream RBC. However, in a previous model (Bos et al., in press) we showed that the results of their study were influenced considerably by their choice of boundary conditions. In fact, one could easily show a 50% increase of the oxygen flux through the plasma to the tissue by altering the boundary conditions.
KeywordsForced Convection Oxygen Transport Boundary Concentration Oxygen Flux Krogh Cylinder
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- Altman, P.L., Gibson, J.R, and Wang, C.C., 1958, Handbook of Respiration, Eds. Dittmar, D.S. and Grebe, R.M., Saunders company, Philadelphia and London.Google Scholar
- Bird, R.B., Stewart, W.E., and Lightfoot, E.N., 1960, Transport Phenomena, Wiley & Sons, New-York.Google Scholar
- Bos, C. Hoofd, L., and Turek, Z., Local plasma convection can be important for oxygen release in tissue capillaries, In: Oxygen Transport to TissueXVI, Adv. Exp. Med. Biol, in press.Google Scholar
- Hoofd, L., 1992, Updating the Krogh model - assumptions and extensions, In: Oxygen Transport in Biological Systems, Cambridge University Press, pp. 197–229.Google Scholar
- Hoofd, L., Olders, J., and Z. Turek, Z., 1990, Oxygen pressures calculated in a tissue volume with parallel capillaries, In: Oxygen transport to tissueXII, Adv. Exp. Med. Biol, 227:21–29.Google Scholar