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Comparison Between Conventional Hemodynamic Monitoring and Polarographic Tissue PO2-Monitoring of the Liver in Early Septicemia of the Pig

  • K. Wagner
  • R. Schäfer
  • W. Gerling
  • A. Michelsen
  • P. Schmucker
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 388)

Abstract

The common therapeutic approach to septicemia - aside from elimination of its cause and antibiosis - consists of the attempt to keep tissue perfusion within physiological limits. A frequently employed therapeutic option is catecholamine administration. Since the reduction of peripheral vascular resistance in septicemia is at least partly due to a TNF induced vascular NO-synthase, the inhibition of this system does affect tissue perfusion as well. While there are controversial results as to the benefit of inhibition of NO-synthase on mean arterial pressure (MAP) and cardiac index (CI) (1) the effect of NO-synthase inhibition on liver circulation has not been described. In addition we were interested in the effect of NO-synthase inhibition on liver pO2.

Keywords

Hepatic Artery Mean Arterial Pressure Cardiac Index Pulmonary Capillary Wedge Pressure Hepatic Oxygen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Amir S, English AM: An inhibitor of nitric oxide production N-nitro-L-arginine-methyl ester, improves survival in anaphylactic shock. Eur J Pharmacol, 203, 125–127, 1991.PubMedCrossRefGoogle Scholar
  2. 2.
    Breslow MJ et al: Effect of vasopressors on organ blood flow during endotoxin shock in pigs. Am J Physiol 253, H291–300,1991.Google Scholar
  3. 3.
    Wang P, Ba ZF, Chaudry IH: Increase of hepatic blood flow during early sepsis is due to increased portal blood flow. Am J Physiol 261, R1507–R1512, 1991.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1996

Authors and Affiliations

  • K. Wagner
    • 1
  • R. Schäfer
    • 1
  • W. Gerling
    • 1
  • A. Michelsen
    • 2
  • P. Schmucker
    • 1
  1. 1.Department of AnesthesiologyMedical University LübeckGermany
  2. 2.Department of SurgeryMedical University LübeckGermany

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