Abstract
The focus of this overview is the occurrence of inhibitors in hemophilia B. Differences exist between hemophilia A and hemophilia B in terms of disease severity and inhibitor incidence, and these are reviewed. The structure of the Factor IX (F.IX) protein and epitopes of F.IX that have been mapped using monoclonal antibodies are also reviewed. Finally, mutations that have been associated with inhibitor formation in hemophilia B are discussed.
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© 1995 Plenum Press, New York
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High, K.A. (1995). Factor IX:Molecular structure, epitopes, and mutations associated with inhibitor formation. In: Aledort, L.M., Hoyer, L.W., Lusher, J.M., Reisner, H.M., White, G.C. (eds) Inhibitors to Coagulation Factors. Advances in Experimental Medicine and Biology, vol 386. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0331-2_6
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DOI: https://doi.org/10.1007/978-1-4613-0331-2_6
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