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Factor IX:Molecular structure, epitopes, and mutations associated with inhibitor formation

  • Katherine A. High
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 386)

Abstract

The focus of this overview is the occurrence of inhibitors in hemophilia B. Differences exist between hemophilia A and hemophilia B in terms of disease severity and inhibitor incidence, and these are reviewed. The structure of the Factor IX (F.IX) protein and epitopes of F.IX that have been mapped using monoclonal antibodies are also reviewed. Finally, mutations that have been associated with inhibitor formation in hemophilia B are discussed.

Keywords

Factor VIII Severe Hemophilia Inhibitor Formation Carboxyglutamic Acid Inhibitor Patient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1995

Authors and Affiliations

  • Katherine A. High
    • 1
  1. 1.Children’s Hospital of PhiladelphiaPhiladelphiaUSA

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