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The incidence of factor VIII inhibitors in patients with severe hemophilia A

  • Leon W. Hoyer
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 386)

Abstract

Inhibitor development is a serious complication of hemophilia A treatment. Although studies of inhibitor prevalence had been published earlier,1–3 the possibility that there is increased risk of inhibitor formation with different Factor VIII (F.VIII)-containing products was first raised when heat-treated concentrates were introduced. However, this concern was quickly dropped when it was apparent that heat treatment was necessary to inactivate HIV. As a result, no systematic study during the 1980s directly compared heat treated and non-heat treated F.VIII concentrates.

Keywords

Factor VIII Recombinant Factor VIII Severe Hemophilia Inhibitor Formation Inhibitor Development 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1995

Authors and Affiliations

  • Leon W. Hoyer
    • 1
  1. 1.Holland LaboratoryAmerican Red CrossRockvilleUSA

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