Abstract
It is now recognized that autoreactive T and B cells are normally present in healthy individuals. Natural antibodies reactive with self-antigens are also present in normal serum and are frequent among hybridomas obtained from healthy individuals. Evidence accumulated in the last ten years indicates that autoreactivity is positively selected during ontogeny, that it provides the basis for an autonomous activity of the normal immune system independent of foreign antigens and that “physiological autoreactivity” is regulated within a network of interactions between variable (V) regions of antibodies and lymphocytes.1
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© 1995 Plenum Press, New York
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Kazatchkine, M.D., Kaveri, S.S., Nydegger, U.E., Sultan, Y. (1995). Variable (V) region-mediated control of autoreactivity to factor VIII. In: Aledort, L.M., Hoyer, L.W., Lusher, J.M., Reisner, H.M., White, G.C. (eds) Inhibitors to Coagulation Factors. Advances in Experimental Medicine and Biology, vol 386. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0331-2_21
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DOI: https://doi.org/10.1007/978-1-4613-0331-2_21
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