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Tolerance and intolerance to factor VIII: A clinical perspective

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Inhibitors to Coagulation Factors

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 386))

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Abstract

In this chapter I will discuss four aspects of inhibitor formation in patients with hemophilia A: why most patients with hemophilia are and remain tolerant to factor VIII (F.VIII), why some patients who are primarily tolerant to F.VIII get inhibitors later, how many patients get inhibitors, and how we can (re-)induce tolerance in patients with inhibitors.

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Author information

Authors and Affiliations

  1. Hemostasis and Thrombosis Center, Department of Hematology, University Hospital, Leiden, The Netherlands

    Ernest Briët

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  1. Ernest Briët
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Editor information

Editors and Affiliations

  1. Mount Sinai Medical School, New York, New York, USA

    Louis M. Aledort

  2. American Red Cross Biomedical Services, Rockville, Maryland, USA

    Leon W. Hoyer

  3. Wayne State University School of Medicine and The Children’s Hospital of Michigan, Detroit, Michigan, USA

    Jeanne M. Lusher

  4. University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

    Howard M. Reisner  & Gilbert C. White II  & 

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© 1995 Plenum Press, New York

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Briët, E. (1995). Tolerance and intolerance to factor VIII: A clinical perspective. In: Aledort, L.M., Hoyer, L.W., Lusher, J.M., Reisner, H.M., White, G.C. (eds) Inhibitors to Coagulation Factors. Advances in Experimental Medicine and Biology, vol 386. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0331-2_18

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  • DOI: https://doi.org/10.1007/978-1-4613-0331-2_18

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-8001-6

  • Online ISBN: 978-1-4613-0331-2

  • eBook Packages: Springer Book Archive

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