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Tolerance and intolerance to factor VIII: A clinical perspective

  • Ernest Briët
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 386)

Abstract

In this chapter I will discuss four aspects of inhibitor formation in patients with hemophilia A: why most patients with hemophilia are and remain tolerant to factor VIII (F.VIII), why some patients who are primarily tolerant to F.VIII get inhibitors later, how many patients get inhibitors, and how we can (re-)induce tolerance in patients with inhibitors.

Keywords

Factor VIII Immune Tolerance Recombinant Factor VIII Severe Hemophilia Inhibitor Development 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1995

Authors and Affiliations

  • Ernest Briët
    • 1
  1. 1.Hemostasis and Thrombosis Center, Department of HematologyUniversity HospitalLeidenThe Netherlands

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