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The function of factor VIIa in hemophilia A: An hypothesis

  • Yale Nemerson
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 386)

Abstract

Since accepting the assignment to talk about this subject, I have reminded myself that I informed my host I hadn’t the slightest idea of how Factor Vila functions in hemophilia! This disclaimer notwithstanding, I do have an hypothesis, albeit one with no experimental validation nor any particular intellectual appeal. It is simply that the activation of Factor VII (F.VII) in vivo is the rate-limiting step in hemostasis, at least in hemophiliacs. I will discuss this concept below.

Keywords

Tissue Factor Tissue Factor Pathway Inhibitor VIla Level Phospholipid Vesicle Wall Shear Rate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Plenum Press, New York 1995

Authors and Affiliations

  • Yale Nemerson
    • 1
  1. 1.Department of Biochemistry and Division of Molecular Medicine, Department of MedicineMount Sinai School of Medicine of the City University of New YorkNew YorkUSA

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