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Ascorbic Acid and Connective Tissue

  • Chapter
Subcellular Biochemistry

Part of the book series: Subcellular Biochemistry ((SCBI,volume 25))

Abstract

Observations of deficient wound healing in sailors suffering from scurvy have been reported by explorers and physicians since the sixteenth century, together with the observation that citrus could have curative properties. Thereafter, Wolbach and Howe (1926) found that in scorbutic guinea pigs there was a deficient production of intercellular matrix which could be reversed by administration of citrus. The discovery, isolation, and chemical characterization of vitamin C was performed in the early thirties. Since then, several studies have been carried out with the aim of characterizing the cellular and matrix defects in scurvy and the effect of vitamin C on the healing process in species unable to synthesize ascorbic acid, such as guinea pigs and humans. Several models have been proposed, including animals made scorbutic during fetal development (Rivers et al., 1970) and postnatal growth (Barnes et al., 1970), and cultured organs and cells grown on chemically defined media in the absence (Jeffrey and Martin, 1966) or in the presence of various concentrations of ascorbic acid (Russell and Manske, 1991).

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Abbreviations

BiP:

heavy chain binding protein

EGF:

epidermal growth factor

FGF:

fibroblast growth factor

hsp70:

heat shock protein 70

IGF:

insulin growth factor

IGFBP:

insulin growth factor binding protein

TGF-β:

transforming growth factor β

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Authors and Affiliations

  1. Department of Biomedical Sciences, Division of General Pathology, University of Modena, Via Campi 287, 41100, Modena, Italy

    Ivonne Pasquali Ronchetti, D. Quaglino Jr. & G. Bergamini

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  1. Ivonne Pasquali Ronchetti
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  2. D. Quaglino Jr.
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  3. G. Bergamini
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  1. Institute of Zoology, University of Mainz, Mainz, Germany

    J. Robin Harris

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Ronchetti, I.P., Quaglino, D., Bergamini, G. (1996). Ascorbic Acid and Connective Tissue. In: Harris, J.R. (eds) Subcellular Biochemistry. Subcellular Biochemistry, vol 25. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0325-1_13

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  • DOI: https://doi.org/10.1007/978-1-4613-0325-1_13

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