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Role of the Dorsocentral Striatum in Contralateral Neglect and Recovery from Neglect in Rats

  • Chapter
Quantitative Neuroscience

Part of the book series: Biocomputing ((BCOM,volume 2))

Abstract

Neglect is a complex and devastating human neuropsychological disorder characterized by a failure to attend to novel or meaningful stimuli presented to the side contralateral to a brain lesion, in the absence of a primary sensory or motor dysfunction. Some manifestation of neglect is found in approximately 40% of all cases of brain damage, although more frequently following right hemisphere damage. The vast majority (80–90%) of all cases of neglect are produced by destruction of one of three cortical regions: the dorsolateral pre-frontal cortex, the cingulate cortex, or the parietotemporal junction [Heilman et al., 1993, Karnath et al., 2001, Mesulam, 1980, Mesulam, 1990]. The neglect syndrome goes far beyond a lack of responsiveness to contralesional stimuli to include dramatic attentional and cognitive spatial deficits. These include several major associated disorders. Patients may exhibit hemispatial neglect in which the patient does not have a cognitive representation of the contralesional hemispace, and will omit details of an imagined scene. Hemiinattention to contralesional stimulation across several or one sensory modality is also quite common. The patients may display hemiakinesia, or a paucity of movement of the contralesional limbs. Inappropriate orientations (allesthesia) may also occur in which the patient will respond or orient to contralesional stimulation as if it came from the ipsilesional side. Extinction to bilateral simultaneous stimulation may also be exhibited.

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Author information

Authors and Affiliations

  1. Department of Physiological Sciences and McKnight Brain Institute, University of Florida, Gainesville, Florida, USA, 32610

    Roger L. Reep & J. L. Cheatwood

  2. Department of Psychology, Northern Illinois University, Dekalb, Illinois, USA, 60115

    J. V. Corwin

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  1. Roger L. Reep
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  2. J. L. Cheatwood
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  3. J. V. Corwin
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Editor information

Editors and Affiliations

  1. Departments of Industrial and Systems Engineering, Biomedical Engineering, and McKnight Brain Institute, University of Florida, USA

    P. M. Pardalos

  2. Departments of Neuroscience, Neurology, Pediatrics, and Biomedical Engineering, University of Florida; VA Medical Center, USA

    J. C. Sackellares

  3. Departments of Pediatrics, Neurology, and Neuroscience, University of Florida, USA

    P. R. Carney

  4. Department of Biomedical Engineering, Arizona State University, USA

    L. D. Iasemidis

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© 2004 Kluwer Academic Publishers

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Reep, R.L., Cheatwood, J.L., Corwin, J.V. (2004). Role of the Dorsocentral Striatum in Contralateral Neglect and Recovery from Neglect in Rats. In: Pardalos, P.M., Sackellares, J.C., Carney, P.R., Iasemidis, L.D. (eds) Quantitative Neuroscience. Biocomputing, vol 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0225-4_10

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  • DOI: https://doi.org/10.1007/978-1-4613-0225-4_10

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7951-5

  • Online ISBN: 978-1-4613-0225-4

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