Abstract
Double minutes (DMs) and homogeneously stained regions (HSRs) provide good examples of phenomena that were originally regarded as cytological oddities but have turned out to be expressions of a fundamental process, called DNA or gene amplification. They arise almost exclusively in transformed and malignant cells. DMs were first described in the 1960s. They occur in most types of solid tumors and many leukemias (Chapter 27). (1976) first described HSRs in human neuroblastoma cell lines and methotrexate-resistant hamster cell lines. HSRs are rare in human tumors but more common in cultured tumor cell lines (Benner et al., 1991).
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Miller, O.J., Therman, E. (2001). DNA and Gene Amplification. In: Human Chromosomes. Springer, New York, NY. https://doi.org/10.1007/978-1-4613-0139-4_25
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DOI: https://doi.org/10.1007/978-1-4613-0139-4_25
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