Abstract
Most of the cell divisions that occur in the germline are mitotic: a series of over 30 in females and over 200 in males (Chapter 9). It is only the final two divisions that are meiotic. What mediates the switch from mitosis to meiosis, and by what mechanisms do all oogonia switch almost simultaneously during fetal life while only one of the two daughter cells from each type B spermatogonial mitosis switches to meiosis throughout the adult life of men? The switch from mitosis to meiosis is the first process of cell differentiation to appear during the evolution of eukaryotes. Consequently, this switch is likely to have an extremely conserved molecular basis, like the other steps in meiosis.
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References
Ashley T, Plug AW, Xu J, et al. (1995) Dynamic changes in Rad51 distribution in chromatin during meiosis in male and female vertebrates. Chromosoma 104:19–28
Barlow AL, Benson FE, West SC, et al. (1997) Distribution of the Rad51 recombinase in human and mouse spermatocytes. EMBO J 16:5207–5215
Barlow AL, Hultén MA (1996) Combined immunocytogenetic and molecular cytogenetic analysis of meiosis I human spermatocytes. Chrom Res 4:562–573
Barlow AL, Hultén MA (1998) Crossing over analysis at pachytene in man. Eur J Hum Genet 6:350–358
Blouin J-L, Christie DH, Gos A, et al. (1995) A new dinucleotide repeat polymorphism at the telomere of chromosome 21q reveals a significant difference between male and female rates of recombination. Am J Hum Genet 57:388–394
Bonnycastle LLC, Yu C-E, Hunt CR, et al. (1994) Cloning, sequencing, and mapping of the human chromosome 14 heat shock protein gene (HSPA2). Genomics 23:85–93
Carpenter ATC (1981) DNA synthesis occurs in recombination nodules. Chromosoma 83:5
Carpenter ATC (1987) Gene conversion, recombination nodules, and the initiation of meiotic synapsis. BioEssays 6:232–236
Chen P-L, Chen C-F, Chen Y, et al. (1998) The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methane-sulfonate treatment. Proc Natl Acad Sci USA 95:5287–5292
Dix DJ, Allen JW, Collins BW, et al. (1996) Targeted gene disruption of HSP70-2 results in failed meiosis, germ cell apoptosis, and male infertility. Proc Natl Acad Sci USA 93:3264–3268
Dolganov GM, Maser RS, Novikov A, et al. (1996) Human Rad50 is physically associated with human Mrel 1: identification of a conserved multiprotein complex implicated in recombinational DNA repair. Mol Cell Biol 16:4832–4841
Edelman W, Cohen PE, Kneitz B, et al. (1999) Mammalian MutS homologue 5 is required for chromosome pairing in meiosis. Nat Genet 21:123–127
Freire R, Murguia JR, Tarsounas M, et al. (1998) Human and mouse homologues of Schizosaccharomyces pombe rad 1+ and Saccharomyces cerevisiae RAD 17: linkage to checkpoint control and mammalian meiosis. Genes Dev 12:2560–2573
Habu T, Taki T, West A, et al. (1996) The mouse and human homologues of DMCl, the yeast meiosis-specific homologous recombination gene, have a common unique form of exon-skipped transcript in meiosis. Nucleic Acids Res 24:470–477
Hunt PA, LeMaire R, Embury P, et al. (1995) Analysis of chromosome behavior in intact mammalian oocytes: monitoring the segregation of a univalent chromosome during female meiosis. Hum Mol Genet 4:2007–2012
John B (1988) The biology of heterochromatin. In: Verma RS (ed) Heterochro-matin: molecular and structural aspects. Cambridge University Press, Cambridge, pp 1–147
Kanaar R, Hoeijmakers JHJ (1998) Genetic recombination: from competition to collaboration. Nature 391:335–337
Keegan KS, Holtzman DA, Plug AW, et al. (1996) The Atr and Atm protein kinases associated with different sites along meiotically pairing chromosomes. Genes Dev 10:2423–2437
Kovalenko OV, Plug AW, Haaf T, et al. (1996) Mammalian ubiquitin-conjugat-ing enzyme Ubc9 interacts with Rad51 recombination protein and localizes in synaptonemal complexes. Proc Natl Acad Sci USA 93:2958–2963
Loidl J, Scherthan H, Den Dünnen JT, et al. (1995) Morphology of a human-derived YAC in yeast meiosis. Chromosoma 104:183–188
Luciani JM, Guichaoua MR, Cau P, et al. (1988) Differential elongation of autosomal pachytene bivalents related to their DNA content in human spermatocytes. Chromosoma 97:19–25
Meuwissen RLJ, Meerts I, Hoovers JMN, et al. (1997) Human synaptonemal complex protein 1 (SCPl): isolation and characterization of the cDNA and chromosomal localization of the gene. Genomics 39:377–384
New JH, Sugiyama T, Zaitseva E, et al. (1998) Rad52 protein stimulates DNA strand exchange by Rad51 and replication protein A. Nature 391:407–410
Nimmo ER, Pidoux AL, Perry PE, et al. (1998) Defective meiosis in telomere-silencing mutants of Schizosaccharomyces pombe. Nature 392:825–828
Orkin SH, Kazazian HH Jr, Antonarakis SE, et al. (1982) Linkage of β-thalassaemia mutations and β-globin gene polymorphisms with DNA polymorphisms in human β-globin gene cluster. Nature 296:627–631
Paquis-Flucklinger V, Santucci-Darmanin S, Paul R, et al. (1997) Cloning and expression analysis of a meiosis-specific mut S homologue: the human MSH4 gene. Genomics 44:188–194
Pathak S, Hsu TC (1979) Silver-stained structures in mammalian meiotic prophase. Chromosoma 70:195–203
Pesce M, Gross MK, Schöler HR (1998) In line with our ancestors: Oct-4 and the mammalian germ. BioEssays 20:722–732
Plug AW, Xu J, Reddy G, et al. (1996) Presynaptic association of Rad51 protein with selected sites in meiotic chromosomes. Proc Natl Acad Sci USA 93:5920–5924
Plug AW, Clairmont CA, Sapi E, et al. (1997) Evidence for a role for DNA polymerase beta in mammalian meiosis. Proc Natl Acad Sci USA 94:1327–1331
Romanienko PJ, Camerino-Otero RD (1999) Cloning, characterization, and localization of mouse and human SPO 11. Genomics 61:156–169
Sathananthan AH, Kola I, Osborne J, et al. (1991) Centrioles in the beginning of human development. Proc Natl Acad Sci USA 88:4806–4810
Scherthan H, Weich S, Schwegler H, et al. (1996) Centromere and telomere movements during early meiotic prophase in mouse and man are associated with the onset of chromosome pairing. J Cell Biol 134:1109–1125
Solari AJ (1980) Synaptonemal complexes and associated structures in microspread human spermatocytes. Chromosoma 81:315–337
Stürzbecher H-W, Donzelmann B, Henning W, et al. (1996) p53 is linked directly to homologous recombination processes via RAD51/RecA protein interaction. EMBO J 15:1992–2002
Szostak JW, Orr-Weaver TL, Rothstein RJ, et al. (1983) The double-strand-break repair model for recombination. Cell 33:25–35
Wettstein D von, Rasmussen SW, Holm PB (1984) The synaptonemal complex in genetic segregation. Annu Rev Genet 18:331–431
Wu T-C, Lichten M (1994) Meiosis-induced double-strand break sites determined by yeast chromatin structure. Science 263:515–518
Xu Y, Ashley T, Brainerd EE, et al. (1996) Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma. Genes Dev 10:2411–2422
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© 2001 Springer Science+Business Media New York
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Miller, O.J., Therman, E. (2001). Details of Meiosis. In: Human Chromosomes. Springer, New York, NY. https://doi.org/10.1007/978-1-4613-0139-4_10
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DOI: https://doi.org/10.1007/978-1-4613-0139-4_10
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