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A Minimal Model of Locomotion Applied to the Steady Gliding Movement of Fish Keratocyte Cells

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Mathematical Models for Biological Pattern Formation

Part of the book series: The IMA Volumes in Mathematics and its Applications ((4522,volume 121))

Abstract

In this paper we present the quantitative analysis of the basic mechanisms underlying the phenomenon of animal cell motility. We describe plausible mechanisms of actin-based protrusive force generation at the cell’s leading edge. We also demonstrate that the dynamics of self-alignment and contraction of the actin-myosin network can explain forward translocation of the cell body. Regulation of graded adhesion between the substrata and the ventral surface of the cell is then discussed. Finally, we derive a one-dimensional mathematical model of cell locomotion applied to fish keratocyte cells.

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Author information

Authors and Affiliations

  1. Dept. of Mathematics, University of California, Davis, CA, 95616, USA

    A. Mogilner

  2. Inst. of Theoretical Dynamics, University of California, Davis, CA, 95616, USA

    A. Mogilner & E. Marland

  3. College of Natural Resources, University of California, Berkeley, CA, 94720, USA

    D. Bottino

Authors
  1. A. Mogilner
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  2. E. Marland
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  3. D. Bottino
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Editor information

Editors and Affiliations

  1. Mathematical Institute, University of Oxford, Oxford, OX1 3LB, UK

    Philip K. Maini

  2. School of Mathematics, University of Minnesota, Minneapolis, MN, 55455, USA

    Hans G. Othmer

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Mogilner, A., Marland, E., Bottino, D. (2001). A Minimal Model of Locomotion Applied to the Steady Gliding Movement of Fish Keratocyte Cells. In: Maini, P.K., Othmer, H.G. (eds) Mathematical Models for Biological Pattern Formation. The IMA Volumes in Mathematics and its Applications, vol 121. Springer, New York, NY. https://doi.org/10.1007/978-1-4613-0133-2_12

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  • DOI: https://doi.org/10.1007/978-1-4613-0133-2_12

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-6524-5

  • Online ISBN: 978-1-4613-0133-2

  • eBook Packages: Springer Book Archive

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