Abstract
The interdisciplinary challenges to discover the underlying mechanisms in the generation of biological pattern and form are central issues in development. Here I briefly discuss a philosophy of such an integrative biology approach. I then describe, by way of example, the successful use of a very simple model — even linear — for the growth of brain tumours in an anatomically accurate brain. All of the model parameters are estimated from experiment and patient data. Even with such a basic model the results highlight the inadequacies of current medical intervention treatment of brain tumours. I conclude with some brief general views on the use of models in biology.
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Murray, J.D. (2001). Biological Pattern Formation — A Marriage of Theory and Experiment. In: Maini, P.K., Othmer, H.G. (eds) Mathematical Models for Biological Pattern Formation. The IMA Volumes in Mathematics and its Applications, vol 121. Springer, New York, NY. https://doi.org/10.1007/978-1-4613-0133-2_1
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DOI: https://doi.org/10.1007/978-1-4613-0133-2_1
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