Abstract
The urinary tract of all animal species used in biomedical research may exhibit a variety of pathologic entities. The etiology and pathogenesis of lesions in some conditions is well understood, but in many other entities and in some species, the study of the pathology of the urinary tract is in its infancy. Many lesions have been described only in morphologic terms and without good clinical histories and laboratory work-ups. With the large number of different species, breeds, and strains utilized in biomedical research, an insufficient number of studies have been made on the pathology of the urinary tract to generalize about the incidence of many specific conditions. Many of the lesions have been reported in single or small numbers of animals. Exceptions do exist, such as the glomerular lesions in New Zealand Black (NZB) mice, which have been studied extensively, in a large number of animals, with sophisticated experimental laboratory techniques.
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References
Alexander, N., Heptinstall, R. H., and Pickering, G. W.(1961)The effect of embolie obstruction of intrarenal arteries in the rabbit. J. Pathol. Bacteriol., 81:225–237.
Andersen, A. C. and Goldman, M.(1970)Growth and Development in the Beagle as an Experimental Dog.Iowa State Press, Ames, Iowa.
Anderson, L. J.(1968a)The glomeruli in canine interstitial nephritis. J. Pathol. Bacteriol.,95:59–65.
Anderson, L. J.(1968b)Arterial disease in canine interstitial nephritis.J. Pathol. Bacteriol.,95:47–52.
Anderson, L. J. and Jarrett, W. F. H.(1971)Membranous glomerulonephritis associated with leukemia in cats. Res. Vet. Sci., 72:179–180.
Andrew, W. and Pruett, D.(1957)Senile changes in the kidneys of Wistar institute rats.Am. J. Anat., 100:51–69.
Armstrong, W. G. and Horsely, H. J.(1966)A sex-determined renal calcification in rats.Nature, 21:980–981.
Astarabadi, T. and Bell, E.(1962)Spontaneous hydronephrosis in albino rats.Nature, 195:392–393.
Babcock, V. I. and Southam, C. M.(1965)Obstructive uropathy in laboratory mice.Proc. Soc. Exptl. Biol. Med., 120:580–581.
Banks, K. L. and Bullock, B. C.(1967)Naturally occurring secondary amyloidosis of a squirrel monkey (Saimirisciuress). JAVMA, 151:839–842.
Barron, C. N. and Saunders, L. Z.(1966)Visceral larva migrans in the dog. Pathol. Vet., 3:315–330.
Baum, M., Stirling, G. A., and Dawson, J. L.(1969)Further study into obstructive jaundice and ischaemic renal damage.Brit. Med. J., 2:229–231.
Berg, B. N.(1965)Spontaneous nephrosis with proteinuria, hyperglobulinemia and hypercholerolemia in the rat.Proc. Soc. Exptl. Biol. Med., 119:417–420.
Berg, B. N.(1967)Pathology of Laboratory Rats and Mice, Black well Scientific Publications, Oxford.
Bielschowsky, M., Helyer, B. J., and Howie, J. B.(1959)Spontaneous hemolytic anemia in mice of the NZB/BL strain. Proc. Univ. Otago Med. School, 37:9–13.
Bittar, E. E. and Misanik, L.(1963)Renal necrotizing papillitis. Am. J. Med., 34:82–98.
Blatherwick, N. R. and Medlar, E. M.(1937)Chronic nephritis in rats fed high protein diet. Arch. Internal Med., 50:572–596.
Bloom, F.(1939)Classification and pathology of renal disease in the dog. Arch. Pathol., 28:236–245.
Bloom, F.(1941)The histopathology of canine leptospirosis. Cornell Vet., 31:266–288.
Bloom, F.(1954)Pathology of the Dog and Cat. American Veterinary Publications, Inc., Evanston, Ill.
Bone, J. F. and Harr, J. R.(1967)Trichosomoidescrassicauda infection in laboratory rats.Lab. Animal Care, 17:321–326.
Boycott, A. E.(1910)A case of unilateral aplasia of the kidney in a rabbit.J. Anat. Physiol., 45:20.
Branca, M., de Petris, S., Allison, A. C., Harvey, J. J., and Hisseh, M. S.(1971)Immune complex diseases. 1. Pathological changes in the kidneys of BALB/c mice neonatallyinfected with Moloneyleukaemogenic and murine sarcoma viruses. Clin. Exptl. Immunol., 9:853–868.
Brand, E., Cahill, G. F., and Kassell, B.(1940)Canine cystinuria. V. Family history of two cystinuric Irish terriers and cystine determinations in dog urine. J. Biol. Chem., 133:431–436.
Bras, G.(1969)Age-associated kidney lesions in the rat.J. Infect. Dis., 120:131–135.
Brody, R. S.(1954)Renalosteitisfibrosacystica in a wire-haired fox terrier. JAVMA, 124:275–278.
Brown, J. R., Hinkle, D. K., Trevethan, W. P., and Kupper, J. L.(1972)Nosematosis in a squirrel monkey (Saimirisciureus): First reported case. SR 72-1, Naval Aerospace Medical Research Laboratory, Pensacola, Fla.
Brown, P.(1971)A case of feline membranous glomerulonephritis.Vet. Res., 50:100–116.
Bruns, V. G.(1970) Spontane Autoimmune Nephritis der Ratte. Z. Versuchstierk., 12:300–312.
Burek, J. D., van Zwieten, M. J., and Stookey, J. L.(1972)Cytoplasmic inclusions in urinary bladder epithelium of the rhesus monkey.Vet. Pathol.,9:212–220.
Burkholder, P. M. and Bergerson, J. A.(1970)Spontaneous glomerulonephritis in the prosimian primate Galago.Am. J. Pathol., 61:437–449.
Burrows, H.(1935)Pathological conditions induced by oestrogenic compounds in the coagulating gland and prostate of the mouse.Am. J. Cancer, 23:490–512.
Carbone, M. G.(1965)Phosphocrystalluria and urethral obstruction in the cat.JAVMA, 147:1195–1200.
Casey, H. W., Kirk, J. H., and Splitter, G. A.(1972)Amyloidosis in a rhesus monkey (Macacamulatta). J. Lab. Animal Sci., 22:588–594.
Casey, H. W., Obeck, D. K., and Splitter, G. A.(1972)Canine Heartworm Disease: The Current Knowledge. University of Florida Press, Gainesville, Fla.
Chapman, W. H.(1964)The incidence of a nematode, Trichosomoidescrassicauda, in the bladder of laboratory rats. Invest. Urol., 2:52–57.
Chapman, W. L., Jr., Crowell, W. A., and Isaac, W.(1973)Spontaneous lesions seen at necropsy in 7 owl monkeys (Aotustrivirgatus). Lab. Animal Sci., 23:434–442.
Christie, B. A.(1973)The occurrence of vesicoureteral reflux and pyelonephritis in apparently normal dogs. Invest. Urol., 10:359–366.
Clark, L. and Seawright, A. A.(1969)Generalized amyloidosis in seven cats.Pathol. Vet., 6:117–134.
Cohen, B., DeBruin, R., and Kort, W.(1970)Heritablehydronephrosis in a mutant strain of Brown Norway rats. Lab. Animal Care, 20:489–493.
Conrad, M. C. and Miller, A. T., Jr. (1956)Age changes in body size, body composition and basal metabolism. Am. J. Physiol., 186:207–210.
Crowell, R. T., Goldston, R. T., Schall, W. D., and Finco, D. R.(1972)Generalized amyloidosis in a cat. JAVMA, 161:1127–1133.
Dahl, L. K. and Schackow, E.(1964)Effect of chronic excess salt ingestion: Experimental hypertension in the rat. Can. Med. Assoc. J., 90:155–160.
Dall, J. A.(1967)Urolithiasis in a suckling puppy. Vet. Rec, 81:599.
David, G. and Ramaswami, L.(1967)Unilateral hypoplasia of the kidney of a female langur (Presbytis entellus entellusDufresne). Folia Primatol.(Basel), 5:312–315.
Davies, D. J., Kennedy, A., and Roberts, C.(1969)Renal medullary necrosis in infancy and childhood. J. Pathol., 99:125–130.
de Martino, C., Brone, C. B., Bellocci, M., and Natali, P. G.(1969)Spontaneous leptospiral infection of the rat kidney. An ultrastructural study.Exptl. Mol. Pathol., 10:27–28.
Deringer, M. and Heston, W.(1956)Abnormalities of the urogenital system in strain AxC 9935 rats. Proc. Soc. Exptl. Biol. Med., 97:312–314.
Deringer, K. K., Dunn, T. B., and Heston, W. W.(1953)Results of exposure of strain C3H mice to chloroform. Proc. Soc. Exptl. Biol., 83:474–479.
Dixon, F. J., Oldstone, M. B. A., and Tonietti, G.(1971)Pathogenesis of immune complex glomerulonephritis of New Zealand mice. J. Exptl. Med., 134:65–71.
Dixon, R. T. and Hyne, R. H. J.(1972)Congenitalmegalo ureter and hydronephrosis in a Keeshound. Australian Vet. J., 48:410–412.
Dodd, D. C. and Staples, E. L. J.(1956)Clinical lead poisoning in the dog.New Zealand Vet. J., 4:1–17.
Dodd, K. and Murphy, E. (1970) Dipetalonemagracile in a capuchin monkey (Cebuscapucinus). Vet. Rec. p. 538.
Dontenwill, W., Kanz, H., and Mohr, V.(1960) Experimentelle Untersuchungen zur Amyloidenstehung Beim Goldhamster.Beitr.Path. Anat., 122:390–405.
Dunn, T. B.(1945)Relationship of amyloid infiltration and renal disease in mice. J. Natl. Cancer Inst., 5:17–27.
Dunn, T. B.(1949)Some observations on the normal and pathologic anatomy of the kidney of the mouse. J. Natl. Cancer Inst., 9:285–301.
Dunn, T. B.(1967)Pathology of Laboratory Rats and Mice, Blackwell Scientific Publications, Oxford.
Dunn, T. B. and Green, A. W.(1966)Morphology of BALB/c mice inoculated with Rauscher virus. J. Natl. Cancer Inst., 36:987–994.
Durand, A., Allen, M., Fisher, M., and Adams, M.(1964)Histology in rats as influenced by age and diet. Arch. Pathol., 77:439–450.
Eschenbrenner, A. B. and Miller, E.(1945)Sex differences in kidney morphology and chloroform necrosis. Science, 102:302–303.
Fabricant, C. G., Rich, L. J., and Gillespie, J. H.(1969)Feline viruses. XI. Isolation of a virus similar to a myxovirus from cats in which urolithiasis was experimentally induced. Cornell Vet., 59:667–672.
Farmer, T. X. and Janeway, C. A.(1942)Infection with the virus of lymphocytic choriomeningitis. Medicine, 21:1–63.
Farrow, B. R. H., Huxtable, C. R., and McGovern, V. J.(1969)Nephrotic syndrome in the cat due to diffuse membranous glomerulonephritis. Pathology, 1:67–72.
Fear, F. A., Pinkerton, M. E., Cline, J. A., Kriewaldt, F., and Kalter, S. S.(1968)A leptospirosis outbreak in aPapio Sp. colony. Lab. Animal Care, 18:22–28.
Feldman, D. B. and Bree, M. M.(1969)Thenephrotic syndrome associated with glomerulonephritis in a rhesus monkey (Macacamulatta). JAVMA, 155:1249–1252.
Fiennes, R. N.(1961)Report of the pathologist for the year 1960. Proc. Zool. Soc., London, 137:173.
Finco, D. R.(1971)Current status of canine urolithiasis.JAVMA, 158:327–335.
Finco, D., Kurtz, H., Low, D., and Perman, V.(1970)Familial renal disease in Norwegian elkhound dogs.JAVMA, 156:747–759.
Flatt, R. E. and Jackson, S. J.(1970)Renalnosematosis in young rabbits. Pathol. Vet., 7:492–497.
Foley, A., Jones, D., Osborn, C. L., Garold, K., and Kimeldorf, D.(1964)A renal lesion associated with diuresis in the aging Sprague-Dawley rat. Lab. Invest., 13:439–450.
Fortner, J. G.(1957)Spontaneous tumors, including gastrointestinal neoplasms and malignant melanomas in the Syrian hamster.Cancer, 10:1153–1156.
Fox, H.(1926)Nephrolithiasis in a black footed cebus (Cebusapiculatus). Rep. Lab. Comp. Pathol., p. 24.
Fox, R., Krinsky, W., and Crary, D.(1971)Hereditary cortical renal cysts in the rabbit.J. Heredity, 62:105–109.
Frye, F. L.(1972)Surgical removal of a cystic calculus from a desert tortoise. JAVMA, 161:600–602.
Fuzi, M. and Cso’ka, R.(1962) Studies on leptospirosis in laboratory albino rat colonies.Acta Microbiol.Acad. Sci. Hung., 9:355–364.
Galloway, J. H., Glover, D., and Fox, W. C.(1964)Relationship of diet and age to metastatic calcification in guinea pigs.Lab. Anim. Care, 14:6–12.
Galten, M. G.(1963)Myobic mange in the mouse leading to skin ulceration and amyloidosis.Am. J. Pathol., 43:855–865.
Garner, F. M. (1975) Personal communication.
Gill, W. B., Finlayson, B., and Vermeulen, C. M.(1959)Prevention of urinary calculi in rats by adding calcium to the diet: Experimental urolithiasis.J. Urol., 82:256–260.
Gillman, J. and Gilbert, C.(1955)Primary amyloidosis in the baboon Papioursinus.Acta Med. Scand., 152:141–147.
Gleiser, C. A., Van Hoosier, G. L., Sheldon, W. G., and Read, W. K.(1971)Amyloidosis and renal paramyloid in a closed hamster colony. Am. Assoc. Lab. Animal Sci., 21:197–202.
Glenner, G. C., Ein, D., and William, T. D.(1972)The immunoglobulin origin of amyloid. Am. J. Med., 52:141–147.
Goodman, D. G. and Garner, F. M.(1972)A comparison of methods for detecting Nosemacuniculi in rabbit urine.Lab. Animal Sci., 22:568–572.
Goulden, B. E.(1969)Clinical observations on the role of urinary infection in the etiology of canine urolithiasis.Vet. Rec., 82:509–514.
Gray, J. E.(1963)Naturally occurring and sulfonamideinduced lesions in rats during a one year toxicity study. Am. J. Vet. Res., 24:1044–1059.
Gray, J. E., Weaver, R. N., and Purmalis, A.(1974)Ultrastructural observations chronic progressive nephrosis in the Sprague-Dawley rat. Vet. Pathol.,11:153–164.
Gude, W. D. and Upton, A. C.(1960)Spontaneous glomerulosclerosis in aging RF mice.J. Gerontol., 15:373–376.
Gude, W. D. and Upton, A. C.(1962)Ahistiologic study of spontaneous glomerular lesions in aging RF mice. Am. J. Pathol., 40:699–706.
Gustafsson, B. E. and Norman, A.(1962)Urinary calculi in germ-free rats.J. Exptl. Med., 116:273–283.
Hain, A. and Robertson, E.(1936)Congenital urogenital anomalies in rats including unilateral renal agenesia. J. Anat., 70:566–576.
Hain, A. and Robertson, E.(1937)Congenital urogenital anomalies in rats including renal agenesia. J. Anat., 72:83–100.
Hall, G. A.(1972)Renal cortical necrosis in a cat. Vet. Pathol.,9:122–130.
Hall, V. E. and MacGregor, W. W.(1937)Relation of kidney weight to body weight in the cat. Anat. Rec., 69:319–331.
Hallberg, C. W.(1953) Dioctophymarenale (Goeze, 1782): A study of the migration routes to the kidneys of mammals and resultant pathology. Trans. Am. Microscop. Soc., 72:351–363.
Halliwell, R. E. W. and Blakemore, W. F.(1972)A case of immune complex glomerulonephritis in a dog.Vet. Rec., 90:275–280.
Hamerton, A. E.(1944)Report on the deaths in the Society’s gardens during the year 1943. Proc. Zool. Soc. London, 114:307–319.
Hamilton, J. M.(1966)Nephritis in the cat. J. Sm. Animal Prac.,7:445–449.
Hartig, V. F. and Hebold, G.(1970)Das Vorkommen von Klossiellen in der Niere der Weissen Ratte. Exptl. Pathol., 4:367–377.
Hartsough, G. R. and Gorham, J. R.(1956)Aleutian disease in mink.Natl. Fur. News, 28:10–11.
Harvey, A. M. and Christensen, H. N.(1964)Uric acid transport system: Apparent absence in the erythrocytes of the Dalmatian coach hound. Science, 145:826–827.
Hasholt, J.(1969)Diseases of Cage and Aviary Birds, Lea &Febiger, Philadelphia.
Helmboldt, C. F. and Jungherr, E. L.(1958)The Pathology of Aleutian disease in mink.Am. J. Vet. Res., 19:212–222.
Helyer, B. J. and Howie, J. B.(1963)Renal disease associated with positive lupus erythematosus tests in a crossbred strain of mice. Nature, 197:197.
Henderson, J. D. and Giddens, W. F.(1970)Amyloidosis and dermatomycosis in C57BL mice.JAVMA, 157:680–684.
Henson, J. B., Leader, R. W., and Gorham, J. R.(1961)Hypergammaglobulinemia in mink. Proc. Soc. Exptl. Biol. Med., 107:919–920.
Henson, J. B., Leader, R. W., Gorham, J. R., and Padgett, G. A.(1966)The sequential development of lesions in spontaneous Aleutian diseases of mink. Pathol. Vet., 3:289–314.
Henson, J. B., Gorham, J. R. and Tanalo, Y.(1967)Renal glomerular ultrastructure in mink affected by Aleutian disease. Lab. Invest., 17:123–139.
Heston, W. E. and Deringer, M. K.(1948)Hereditary renal disease and amyloidosis in mice. Arch. Pathol., 46:49–59.
Hewitt, H. B.(1956)Renal necrosis in mice after accidental exposure to chloroform. Brit. J. Exptl. Pathol., 37:32.
Hicks, J. D. and Burnet, F. M.(1966)Renal lesions in the “auto-immune” mouse strains of NZB and F1NZB X NZW. J. Pathol. Bacteriol.,91:467–477.
Hill, W.(1964)Congenital abnormalities of the urinary tract in primates. Folia Primatol.(Basel),2:111–118.
Hotchin, J.(1971)Virus, cell surface, and self.Am. J. Clin. Pathol.,56:333–349.
Hotchin, J. and Collins, D. H.(1964)Glomerulonephritis and late onset disease of mice following neonatal virus infection.Nature, 164:1357–1359.
Hottendorf, G. H. and Nielsen, S. W.(1968)Pathologic report of twenty-nine necropsies on dogs with mastocytoma. Pathol. Vet., 5:102–121.
House, W. B. and Hogan, A. G.(1955)Injury to guinea pigs that follows a high intake of phosphates.J. Nutr., 55:507–517.
Houser, W. D. and Frank, N.(1970)Accidental lead poisoning in a rhesus monkey (Macacamulatta).JAVMA, 157:1919–1922.
Hunt, R. D., King, N. W., and Foster, H. L.(1972)Encephalitozoönosis: Evidence for vertical transmission. J. Infect. Dis., 126:212–214.
Jackson, O. F. and Sutor, D. J.(1970)Ammonium acid urate calculus in a cat with a high uric acid excretion possibly due to a renal tubular reabsorption defect. Vet. Rec., 84:335–337.
Jacobsen, L., Andersen, E., and Thorborg, J. V.(1964) Accidental chloroform nephrosis in mice.ActaPathol.Microbiol. Scand., 61:503–513.
Jakob, W.(1971)Spontaneous amyloidosis of mammals.Vet. Pathol.,8:292–306.
Jamkhedkar, P. and Ajinkya, S.(1966)Unilateral agenesis of kidney and testicle in a dog. Indian Vet. J., 43:128–129.
Jolly, D. and Worden, A.(1966)Urolithiasis in the dog. III. Nutritional aspects. J. Sm. Animal Pract.,7:549–552.
Jubb, K. V. F. and Kennedy, P. C.(1963)Pathology of Domestic Animals. Academic Press, New York & London.
Juhn, M. and Mitchell, J. B.(1929)On endocrine weights in brown leghorns. Am. J. Physiol., 88:177–182.
Kajima, M. and Pollard, M.(1970)Ultrastructural pathology of glomerular lesions in gnotobiotic mice with congenital lymphocytic choriomeningitis (LCM) virus infection.Am. J. Pathol., 61:117–130.
Kaufman, F., Soirez, R., and Tasker, J.(1969)Renal cortical hypoplasia with secondary hyperparathyroidism in the dog.JAVMA, 155:1679–1685.
Kaur, J., Chakravarti, R. N., Chugh, K. S., and Chuttani, P. N.(1968)Spontaneously occurring renal diseases in wild rhesus monkeys. J. Pathol. Bacteriol.,95:31–36.
Kennard, M. A. and Willner, M. D.(1941)Findings in 216 routine autopsies of Macacamulatta.Endocrinology, 28:955–976.
Kennard, M. A. and Willner, M. D.(1941)Weights of brains and organs of 132 New and Old World monkeys.Endocrinology, 28:977–984.
Kennedy, G. C.(1957)Effects of old age and over-nutrition on the kidney.Brit. Med. Bull., 13:67–70.
Kennedy, G. C., Glear, C. T. G., and Parker, R. A.(1960)Renal disease and secondary potassium depletion in aging rats. Quart. J. Exptl. Physiol., 45:82–87.
Kihlstrum, J. and Clements, G.(1969)Spontaneous pathologic findings in Long-Evans rats.Lab. Animal Care, 79:710–715.
Kilham, L., Low, R. J., Conti, S. F., and Dallenbach, F. D.(1962)Intranuclear inclusions and neoplasms in the kidneys of wild rats. J. Natl Cancer Inst., 29:863–871.
Kim, C. and Kalter, S.(1972)Unilateral renal aplasia in an African baboon (Papio sp.). Folia Primatol.(Basel), 17:157–159.
Kirschbaum, A.(1944)Polycystic kidney disease in inbred mice. Anat. Rec., 88:440.
Kirschbaum, A.(1944)Spontaneous glomerulonephritis in mice.Proc. Soc. Exptl. Biol. Med., 55:280–281.
Kirschbaum, A., Bell, E. T., and Gordon, J.(1949)Spontaneous and induced glomerulonephritis in an inbred strain of mice.J. Lab. Clin. Med., 34:209–220.
Krohn, K., Mero, M., Oksanen, A., and Sandholm, M.(1971)Immunologic observations in canine interstitial nephritis.Am. J. Pathol., 65:157–167.
Kurtz, J. M., Russell, S. W., Lee, J. C., Slauson, D. O., and Schechter, R. D.(1972)Naturally occurring canine glomerulonephritis. Am. J. Pathol., 67:471–481.
Lane, J. G.(1973)Canine ectopic ureter—Two further case reports. J. Sm. Animal Pract.,14:555–560.
Lanier, B. F., McDuffie, F. C., and Holley, K. E.(1971)Role of C5 in the nephritis of NZB/W mice.J. Immunol., 106:740–745.
Larkin, H. A., Vanda, M. L., and Kidder, D. E.(1972)Nephrotic syndrome in a dog.J. Sm. Animal Pract.,13:333–337.
Leader, R. W., Wagner, B. M., Henson, J. B., and Gorham, J. R.(1963)Structure and histochemical observation of livers and kidneys in Aleutian disease of mink. Am. J. Pathol., 48:33–53.
Levine, C. J., Mann, W., Hodge, H. C., Ariel, I., and DuPont, O.(1941)Distribution of body weight in the organs and tissues of the rabbit. Proc. Soc. Exptl. Biol Med., 47:318–321.
Lewis, R. M., Schwartz, R., and Henry, W. B. Jr. (1965)Canine systemic lupus erythematosus.Blood, 25:143–160.
Li, H. Y. and Davis, D. E.(1952)The Prevalence of carriers of Leptospira and Salmonella in Norway rats of Baltimore.Am. J. Hyg., 56:90–100.
Lisco, H. and Biskind, G. R.(1941)Lesions of the bladder and of the prostate of mice receiving pellets of crystalline estrone.Endocrinology, 29:772–778.
Lozzio, B. and Chernoff, A.(1967)Hereditary renal disease in a mutant strain of rats. Science, 156:1742–1744.
Lucas, J. A., Moser, J. H., and Schardein, J. L.(1972)Inclusion bodies of the epithelium of the urinary bladder in the rhesus monkey.Anat. Rec., 172:651–658.
Lucke, V. M.(1968)Renal disease in the domestic cat. J. Pathol. Bacteriol.,95:67–90.
Lucke, V. M. and Hunt, A. C.(1965)Interstitialnephropathology and papillary necrosis in the domestic cat. J. Pathol. Bacteriol.,89:723–728.
Lucke, V. M. and Hunt, A. C.(1967)Renal calcification in the domestic cat. Pathol. Vet., 4:20–136.
Lyon, M. and Hulse, E.(1971)Congenital kidney disease of mice resembling human nephrophthisis.J. Med. Genet., 8:41–48.
McClure, H. M. and Guilloud, N. B.(1972)The Chimpanzee: Behavior, Growth and Pathology of Chimpanzees, University Park Press, Baltimore, London, Tokyo.
McConnell, E. E. (1973) Personal communication. Wright-Patterson Air Force Base, Ohio.
McCraw, A. P., Rotheram, K., Sim, A. K., and Warwick, M. H.(1973)Unilateral renal aplasia in the baboon. J. Med. Prim., 2:249–251.
McCully, R. M. and Lieberman, L. L.(1961)Histopathology in a case of feline urolithiasis. Can. Vet. J., 2:52–61.
Machado, E. and Lozzio, B.(1972)Congenital renal structural alterations in a mutant strain of rats. Invest. Urol., 19:78–83.
McIntyre, W. I. M. and Montgomery, G. L.(1957)Renal lesions in Leptospiracanicola infections in dogs. J. Pathol. Bacteriol.,64:145–160.
McKissick, G. E., Ratcliffe, H. L., and Koestner, A.(1968)Enzootic toxoplasmosis in caged squirrel monkeysSaimirisciurus.Pathol. Vet., 5:538–560.
McNeil, C. W.(1948)Pathological changes in the kidneys of minks due to infection with Dioctophymarenale (Goeze, 1782), the giant kidney worm of mammals. Trans. Am. Microroscop. Soc., 67:257–261.
Magnusson, G. and Ramsey, C.(1971)Urolithiasis in the rat. Lab. Animals, 5:153–162.
Maruffo, C. and Cramer, D.(1967)Congenital renal malformations in monkeys. Folia Primatol.(Basel), 5:305–311.
Maurer, F.(1964)Lymphocytic choriomeningitis.Lab. Animal Care, 14:415–419.
Mellors, R. C.(1965)Autoimmune disease in NZB/BL mice. I. Pathology and pathogenesis of a model system of spontaneous glomerulonephritis. J. Exptl. Med., 122:25–40.
Mellors, R. C., Shiroi, T., Aoki, T., Huebner, A. J., and Krawazynski, K.(1971)Wild-type gross leukemia virus and the pathogenesis of the glomerulonephritis of New Zealand mice.J. Exptl. Med., 133:113–131.
Monlux, A. W.(1953)The Histopathology of nephritis of the dog. I. Introduction. II. Inflammatory interstitial diseases. Am. J. Vet. Res., 14:425–439.
Monlux, A. W.(1953)The histopathology of nephritis in the dog. IIII: Inflammatory vascular disease of the kidney. Am. J. Vet. Res., 14:440–447.
Moon, H. W., Barnes, D. M., and Higbee, J. M.(1969)Septic embolic actinobacillosis.Pathol. Vet., 6:481–486.
Morgan, W.(1953)Inherited congenital kidney absence in an inbred strain of rats. Anat. Rec., 115:635–639.
Mullink, J. W. M. A.(1971)Glomerulonephritis Bij De Hond, Tijdschr. Diergeneesk, 96:1587–1599.
Muri, G.(1965)Agenesis and dysgenesis of the canine kidney.JAVMA, 146:1120–1124.
Murray, M. and Wright, N. G.(1974)A Morphologic study of canine glomerulonephritis.Lab. Invest., 30: 213–221.
Murray, M., Pirie, H. M., Thompson, H., Jarrett, W. F. H., and Wiseman, A.(1971)Glomerulonephritis in a dog. A histological and electron microscopical study.Res. Vet. Sci., 22:493–495.
Nordstoga, K.(1967)Spontaneous bilateral renal cortical necrosis in animals.Pathol. Vet., 4:233–244.
Norin, L. C.(1964)Absence of antigenic component of complement in NZB mice. J. Immunol., 94:437–443.
Obel, A., Lennart, N., and Osheim, A.(1964)Light and electron microscopical studies of the renal lesions in dogs with pyometra.Acta Vet. Scand., 5:146–178.
O’Dell, B. L., Vandepopuliere, J. M., Morris, E. R., and Hogan, A. G.(1956)Effect of a high phosphorus diet on acid-base balance in guinea pigs. Proc. Soc. Exptl. Biol. Med.,91:220–223.
O’Dell, G. B., Natzschka, J. C., and Storey, G. N. B.(1967)Bilirubin nephropathy in the Gunn strain of rat. Am. J. Physiol., 212:931–938.
Oldstone, M. B. A. and Dixon, F. J.(1969)Pathogenesis of chronic diseases associated with persistent lymphocytic choriomeningitis virus infection. I. Relationship of antibody production to disease in neonatally infected mice. J. Exptl. Med., 129:483–505.
Orsini, M. W.(1952)The piebald hamster. A mutation showing growth retardation and urogenital abnormalities. J. Heredity, 43:37–40.
Osathanondh, V. and Potter, E.(1964a)Pathogenesis of polycystic kidneys: Type I due to hyperplasia of interstitial portions of collecting tubules.Arch. Pathol., 77:466–473.
Osathanondh, V. and Potter, E.(1964b)Pathogenesis of polycystic kidneys: Type 2 due to inhibition of ampullary activity.Arch. Pathol., 77:474–484.
Osathanondh, V. andPotter, E.(1964c)Pathogenesis of polycystic kidneys: Type 3 due to multiple abnormalities of development.Arch. Pathol., 77:485–501.
Osathanondh, V. and Potter, E.(1964d)Pathogenesis of polycystic kidneys: Type 4 due to urethral obstruction.Arch. Pathol., 77:502–509.
Osborne, C. A. and Vernier, R. L.(1973)Glomerulonephritis in the dog and cat: A comparative review. JAAHA, 9:101–127.
Osborne, C. A., Johnson, K. W., Perman, V., and Schall, W. D.(1968)Renal amyloidosis in the dog.JAVMA, 153:669–688.
Osborne, C. A., Stevens, J. B., McClean, R., and Vernier, R. L.(1973)Membranous lupus glomerulonephritis in a dog.JAAHA, 9:295–300.
Owen, R. op R.(1973)Canine ureteral ectopia—A review 2.Incidence, diagnosis and treatment.J. Sm. Animal Pract.,14:419–427.
Pascal, R. R., Koss, M. N., and Kassel, R. L.(1973)Glomerulonephritis associated with immune complex deposits and viral particles in spontaneous murine leukemia. Lab. Invest., 29:159–165.
Pascal, R. R., Rollwagon, F. M., Harding, T. A., and Schiavone, W. A.(1975)Glomerular immune complex deposits associated with mouse mammary tumor. Cancer Res., 35:302–304.
Pearce, L.(1916)Klossiella infection of the guinea pig.J. Exptl. Med., 23:431–442.
Pearson, H., Gibbs, C., and Hillson, J.(1965)Some abnormalities of the canine urinary tract. Vet. Rec., 77:775–780.
Percy, D., Carmichael, L., Albert, D., King, J., and Jonas, A.(1971)Lesions in puppies surviving infection with canine herpesvirus.Vet. Pathol.,8:37–53.
Perry, S. W.(1965)Proteinuria in the Wistar rat. J. Pathol. Bacteriol.,89:729–733.
Persson, F., Persson, S., and Asheim, A.(1961)Renal cortical hypoplasia in dogs.Acta Vet. Scand., 2:68–84.
Platt, H.(1951)Canine chronic nephritis. I. Observations on the pathology of the kidney. J. Comp. Pathol., 67:140–149.
Pollard, M. and Kajima, M.(1970)Lesions in aged germ-free rats. Am. J. Pathol., 61:25–31.
Pollard, M., Sharson, N., and Teak, B. A.(1968)LCM virus-induced immunopathology in congenitally infected gnotobiotic mice. Perspect.Virol. Med.,6:193–207.
Pollock, S. and Schoen, S.(1971)Urinary incontinence associated with congenital ureteral valves in a bitch.JAVMA, 159:332–335.
Porter, D. D., Dixon, F. J., and Larsen, A. E.(1965)Metabolism and function of gamma globulin of Aleutian disease of mink.J. Exptl. Med., 121:889–906.
Porter, D. D., Larsen, A. E., and Porter, G. H.(1969)Pathogenesis of Aleutian mink disease. J. Exptl. Med., 130:575–589.
Porter, P.(1963)Urinary calculi in the dog. II. Urate stones and purine metabolism. J. Comp. Pathol., 73:119–135.
Pryor, W. H., Jr., Chang, C., and Raulston, G.(1969)Urolithiasis in a Taiwan monkey (Macacacyclopis). Lab. Animal Care, 19:862–865.
Rapp, J. P.(1962)Terminal formation of urethral plugs in male mice.Proc. Soc. Exp. Biol. Med., 111:243–245.
Rawlings, C.(1969)Bilateralhydronephrosis and hydroureter in a young dog. JAVMA, 155:26–29.
Recher, L., Tanaka, T., Sykes, J. A., Yumuto, T., Seman, G., Young, L., and Dmochowski, L.(1966)Further studies on the biological relationship of murine leukaemia viruses and on kidney lesions of mice with leukaemia induced by these viruses. J. Nat. Cancer Inst. Monogr.,22:459–470.
Rich, L. J. and Fabricant, C. G.(1971)Experimental production of urolithiasis in male cats.JAVMA, 158:974–976.
Rich, L. J. and Kirk, R.(1969)The relationship of struvite crystals to urethral obstruction in cats. JAVMA, 154:153–157.
Rich, L. J., Fabricant, C. G., and Gillespie, J. H.(1971)Virus induced urolithiasis in male cats. Cornell Vet., 67:542–553.
Richter, W. R. and Moize, S. M.(1970)Ultrastructural nature of canine distemper inclusions in the urinary bladder.Pathol. Vet., 7:346–352.
Robbins, J. D., Oltjen, R., Cabell, C., and Dolnick, E.(1965)Influence of varying levels of dietary minerals on the development of urolithiasis, hair growth, and weight gains in rats. J. Nutr., 85:355–361.
Roberts, J. A., Clayton, J. D., and Seibold, H. R.(1972)The natural incidence of pyelonephritis in nonhuman primate. Invest. Urol., 9:276–281.
Root, C. R. and Scott, R. C.(1971)Emphysematous cystitis and other manifestations of diabetes mellitus in dogs and cats.JAVMA, 158:721–728.
Rupple, B.(1955)Congenital polycystic disease of the kidney occurring in mice. J. Natl. Cancer Inst., 15:1183–1187.
Russfield, A. B. and Green, M. N.(1965)Serum protein patterns associated with amyloidosis in the Syrian hamster. Am. J. Pathol., 46:59–69.
Ryan, C. P. and Smith, R. A.(1971)Bilateral nephrolithiasis in a cat. JAVMA, 158:1946–1947.
Sauer, R. M., Zook, B. C., and Garner, F. M.(1970)Demyelinating encephalomyelopathy associated with lead poisoning in nonhuman primates. Science, 169:1091–1093.
Saxton, J. A., Jr., and Timball, G. C.(1941)Relation of nephrosis and other disease of albino rats to age and to modification of diet.Arch. Pathol., 32:951–965.
Scher, S. and Weisbroth, S. H.(1974)Unilateral renal and urogenital tract aplasia in a guinea pig (Cavia Porcellus). Lab. Animal Sci., 24:370–371.
Schlumberger, H.(1950)Polycystic kidney (mesonephros) in the goldfish. Arch. Pathol., 50:400–410.
Schmidt, R. E. and Butler, T. M.(1973)Glomerulonephritis and uremia in a chimpanzee.J. Med. Prim., 2:144–154.
Scott, R. C., Hurvitz, A. I., Ehrenreich, T., and Derr, J. W.(1975)Idiopathic membranous glomerulonephritis in a cat.JAAHA, 11:53–59.
Seibold, H. R., Roberts, J. A., and Wolf, R. H.(1971)Idiopathic muscle necrosis with apparent myoglobinuria in Macacaarctoides. Lab. Animal Sci., 21:242–246.
Sellers, A., Rosenfeld, S., and Friedman, N.(1960)Spontaneous hydronephrosis in the rat.Proc. Soc. Exptl. Biol. Med., 104:512–515.
Shadduck, J. A. and Pakes, S. P.(1971)Encephalitozoönosis (nosematosis) and toxoplasmosis.Am. J. Pathol., 64:657–674.
Sheehan, H. L. and Davis, J. C.(1958)Complete permanent renal ischaemia. J. Pathol. Bacteriol.,76:569–587.
Shimkin, M. B., Shimkin, P. M., and Andervort, H. B.(1963)Effects of estrogens on kidney weight in mice. J. Nat. Cancer Inst., 30:135–141.
Shirahama, T. and Cohen, A. S.(1967)High resolution electron microscopic analysis of the amyloid fibril.J. Cell Biol., 33:679.
Shive, R. J., Green, S. S., Evans, L. B., and Garner, F. M.(1969)Leptospirosis in Barbary apes (Macacasylvana). JAVMA, 155:1176–1178.
Shubik, P. and Ritchie, A. C.(1953)Sensitivity of male dba mice to the toxicity of chloroform as a laboratory hazard. Science, 117:285.
Siller, W. G.(1959)Pathology of avian glomerulonephritis.J. Pathol. Bacteriol.,78:57–65.
Silverstein, E., Sokoloff, L., Mickelsen, O., and Jay, G., Jr. (1961)Primary polydipsia and hydronephrosis in an inbred strain of mice.Am. J. Pathol., 38:143–157.
Simms, H. S.(1967)Pathology of Laboratory Rats and Mice, Blackwell Scientific Publications, Oxford.
Simms, H. S. and Berg, B. N.(1957)Longevity and the onset of lesions in male rats.J. Gerontol., 12:244–252.
Simpson, C. F., Jackson, R. F., and Bradley, R. E. (1972) Canine Heartworm Disease: The Current Knowledge. University of Florida Press, Gainesville, Fla.
Slauson, D. D., Gribble, D. H., and Russell, S. W.(1970)Aclinicopathological study of renal amyloidosis in dogs. J. Comp. Pathol., 80:335–343.
Slauson, D. O., Russell, S. W., and Schechter, R. D.(1971)Naturally occurring immunocomplex glomerulonephritis in the cat. J. Pathol., 103:131–133.
Smith, T.(1889)Some observations on coccidia in renal epithelium of the mouse. J. Comp. Med. Surg., 10:211–217.
Smith, T. and Florence, L.(1925)Encephalitozoöncuniculi as a kidney parasite in the rabbit.J. Exptl. Med., 41:25–35.
Smith, T. and Johnson, H. P.(1902)On a coccidium (Klossiellamuris) (Gen. et Spec. Nove.) parasitic in the renal epithelium of the mouse. J. Exptl. Med., 6:303–316.
Snell, K.(1967)Pathology of Laboratory Rats and Mice, Blackwell Scientific Publications, Oxford.
Snell, K. C. and Stewart, H. L.(1967)Neoplastic and non-neoplastic renal disease in Praomys (Mastomys) natalensis.J. Natl. Cancer Inst., 39:95–117.
Sokoloff, L. and Barile, M. F.(1962)Obstructive genitourinary disease in male STR/LN mice.Am. J. Pathol., 41:233–244.
Sparschu, G. L. and Christie, R. J.(1968)Metastatic calcification in a guinea pig colony: A pathological survey. Lab. Animal Care, 18:520–526.
Sprague, V. and Vernick, S. H.(1971)Ultrastructure of Encephalitozoöncuniculi (Microsporidia, Nosematidae) and its taxonomic significance.J. Protozool., 18:560–569.
Stebley, R. W. and Rudofsky, U.(1971)Spontaneous renal lesions and glomerular deposits of Igg and complement in guinea pigs.J. Immunol., 107:1192–1196.
Steele, J. H.(1960)Epidemiology of leptospirosis in the United States and Canada. JAVMA, 136:247–252.
Swann, H. G. and Railey, M. J.(1950)Weights of right and left kidneys in dogs.Tex. Rep. Biol. Med., 17:256–258.
Takeda, T. and Grollman, A.(1970)Spontaneously occurring renal disease in the guinea pig. Am. J. Pathol., 60:103–118.
Taylor, P. L., Hanson, L. E., and Simon, J.(1970)Serologic, pathologic, immunologic features of experimentally induced leptospiral nephritis in dogs. Am. J. Vet. Res., 31:1033–1049.
Thompson, S. W. II, Wiegand, R. G., Thomassen, R. W., Harrison, M., and Turbyfill, C. L.(1959b)The protein nature of acidophilic crystalline intranuclear inclusions in the liver and kidney of dogs. Am. J. Pathol., 35:1105–1111.
Thompson, S. W., II, Cook, J. E., and Hoey, H.(1959a)Histochemical studies of acidophilic crystalline intranuclear inclusions in the liver and kidney of dogs. Am. J. Pathol., 35:607–623.
Tonietti, G., Oldstone, M. B. A., and Dixon, F. J.(1970)The effect of induced chronic viral infections of immunologic disease of New Zealand mice. J. Exptl. Med., 132:89–109.
Treacher, R. J.(1966)Urolithiasis in the dog. II. Biochemical aspects. J. Sm. Animal Pract.,7:537–547.
Trevino, G. S.(1955)Renalosteitisfibrosacystica in a cocker spaniel, the “rubber jaw” syndrome. Southwest. Vet., 8:338–340.
Tsan, M. F., Jones, T. C., Thornton, G. W., Levy, H. L., Gilmore, C., and Wilson, T. H.(1972a)Canine cystinuria: Its urinary amino acid pattern and genetic analysis. Am. J. Vet. Res., 33:2455–2461.
Tsan, M. F., Jones, T. C., and Wilson, T. H.(1972b)Canine cystinuria: Intestinal and renal amino acid transport. Am. J. Vet. Res., 33:2463–2468.
Tucker, M. J. and Baker, D. C. S. B.(1967)Pathology of Laboratory Rats and Mice, Blackwell Scientific Publications, Oxford.
Tuffery, A. A.(1966)Urogenital lesions in laboratory mice. J. Pathol. Bacteriol.,91:301–309.
Udall, R. H. and Chen Chow, F.(1969)Advances in Veterinary Sciences and Comparative Medicine. Academic Press, New York.
Van Pelt, R. W. and Sachtjen, J. F.(1973)Congenital unilateral renal hypoplasia complicated by chronic interstitial nephritis in a dog. Vet. Med. Sm. Animal Clin. July: 745–748.
Van Reen, R., Lyon, H., and Losee, F.(1959a)Urolithiasis in the rat. I. The influence of diet on the formation and prevention of calcium citrate calculi. J. Nutr., 69:392–396.
Van Reen, R., Indacoches, N., and Hess, W.(1959b)Urolithiasis in the rat.Studies on the effect of diet on the excretion of calcium, citric acid, and phosphate.J. Nutr., 69:397–402.
Vermeulen, C. W., Ellis, J. E., and Hsu, T. C.(1966)Experimental observations on the pathogenesis of urinary calculi.J. Urol., 95:681–690.
Wachstein, M.(1949)Studies on inclusion bodies. I. Acid-fastness of nuclear inclusion bodies that are induced by ingestion of lead and bismuth. Am. J. Clin. Pathol.,19:608–614.
Wallace, M. and Spickett, S.(1967)Hydronephrosis in mouse, rat, and man.J. Med. Genet., 4:73–82.
Walter, W. G. and Baldwin, D. E.(1963)Observations on the parathyroid glands of guinea pigs affected with metastatic calcification. Can. J. Comp. Med., 27:140–146.
Warner, N. L.(1971)Spontaneous hydronephrosis in the inbred mouse strain NZC. Australian J. Exptl. Biol. Med. Sci., 49:477–486.
Weaver, A. D.(1970)Canine urolithiasis: Incidence, chemical composition, and outcome of 100 cases. J. Sm. Animal Pract.,11:93–107.
Webster, S. H. and Liljegren, E. J.(1949)Organ:body weight ratios for certain organs of laboratory animals. II. Guinea pigs. Am. J. Anat., 85:199–230.
Webster, S. H. and Liljegren, E. J.(1955)Organ:body weight ratios for certain organs of laboratory animals. III. White Swiss mouse.Am. J. Anat., 97:129–153.
Webster, S. H., Liljegren, E. J., and Zimmer, D. J.(1947)Organ:body weight ratios for liver, kidney and spleen of laboratory animals. I. Albino rat. Am. J. Anat., 81:477–513.
West, W. T. and Murky, E. D.(1965)Sequence of deposition of amyloid in strain A mice and relationship of renal disease. J. Natl. Cancer Inst., 35:167–174.
White, E. G.(1966)Symposium on urolithiasis in the dog. I. Introduction and incidence. J. Sm. Animal Pract.,7:529–535.
Whitehead, J.(1964)Feline Medicine and Surgery.American Veterinary Publication, Santa Barbara, Calif.
Wilgram, G. F. and Ingle, D. J.(1959)Renal-cardiovascular pathologic changes in aging female breeder rats.Arch. Pathol., 68:690–703.
Woodhead, A. E.(1950)Life history cycle of the giant kidney worm, Dioctophymarenale (Nematoda), of man and many other mammals. Trans. Am. Microscop. Soc., 69:21–46.
Wright, N. G.(1967)The relationship between the virus of infectious canine hepatitis and interstitial nephritis. J. Sm. Animal Pract.8:67–70.
Wright, N. G.(1970)Interstitial nephritis in a dog associated with infectious canine hepatitis virus. Vet. Rec., 86:92–93.
Yumoto, T. and Dmochowski, L.(1968)Further studies on renal lesions of New Zealand black (NZB/BL) strain of mice. Tex. Rep. Biol. Med., 36:381–400.
Zook, B. C.(1972)The pathologic anatomy of lead poisoning in dogs. Pathol. Vet.9:310–327.
Zook, B. C. and Sauer, R. M.(1973)Leucoencephalomyelosis in nonhuman primates associated with lead poisoning. J. Wildlife Dis., 9:61–63.
Zwart, P.(1964)Studies on renal pathology in reptiles.Pathol. Vet.1:542–556.
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Casey, H.W., Ayers, K.N., Robinson, F.R. (1978). The Urinary System. In: Benirschke, K., Garner, F.M., Jones, T.C. (eds) Pathology of Laboratory Animals. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-9942-4_3
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