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Critical Care Medicine Manual pp 247–257Cite as

Tissue Blood Flow and Oxygen Transport in Critically Ill Patients

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Abstract

The expectation that oxygen might improve the ailing patient is nearly as old as the discovery of oxygen itself. The belief that his newly found “dephlogisticated air” would be of medical benefit was recorded by Joseph Priestly after the meager trial of being sampled by two mice and himself [35]. John Hunter proposed its use for resusciation in 1776 [21]. Since then, the desire to get more oxygen into patients has been pursued with great vigor, even though its pulmonary toxicity had been noted in the literature (albeit in mice) by 1796 [4]. Since then, the methodology, understanding, and limitations of getting more oxygen to the tissues have been, in large part, worked out. Now the problems of oxygen delivery have become so seemingly trivial that they are prematurely being treated with indifference by those who fund research programs. This will continue unless something dramatic is offered, such as extracorporeal oxygenation.

“Anoxaemia not only stops the machine but wrecks the machinery.”

J. S. Haldane

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References

  1. Ayres, S. M., Gianelli, S., and Mueller, H. (1974). Care of the Critically Ill. New York: Appleton-Century-Crofts.

    Google Scholar 

  2. Baek, S.-M., Makabali, G. G., Bryan-Brown, C. W., Kusek, J., and Shoemaker, W. C. (1973). Inadequacy of high CVP as a guide to volume therapy. Surg. Forum 24:14–16.

    PubMed  CAS  Google Scholar 

  3. Barcroft, J. (1920). On anoxaemia. Lancet 2:485–489.

    Google Scholar 

  4. Beddoes, J., and Watt, J. (1796). Considerations on the medicinal use of factitious airs. Bristol: Johnson.

    Google Scholar 

  5. Braunwald, E., and Maroko, P. R. (1973). Investigations on the protection of the ischemic myocardium. Trans. Am. Clin. Climatol. Assoc. 84:80–115.

    PubMed  CAS  Google Scholar 

  6. Braunwald, E., and Maroko, P. R. (May 1973). Protection of the ischemic myocardium. Hosp. Pract. 61–74.

    Google Scholar 

  7. Bryan-Brown, C. W. (1973). Respiratory intensive care: a review with possible indications for membrane oxygenator support. Mt. Sinai J. Med. 40:181.

    PubMed  CAS  Google Scholar 

  8. Bryan-Brown, C. W., Baek, S.-M., Makabali, G., Shoemaker, W. C. (1973). Consumable oxygen: Study of oxygen availability in relation to oxy-hemoglobin dissociation. Crit. Care Med. 7:26–31.

    Google Scholar 

  9. Bryan-Brown, C. W. (in press). Oxygen transport and the oxy-hemoglobin dissociation curve in the critically ill patient. In: Berk, J. L. et al. (eds.), Manual of Critical Care Medicine, Boston: Little Brown, Ch. 17.

    Google Scholar 

  10. Bryan-Brown, C. W., Baek, S.-M., Makabali, G., and Shoemaker, W. C. (1974). Hemodynamic responses on oxygen delivery after methylprednisolone sodium succinate. In: Glenn, T. (ed.), Steroids and Shock, Baltimore: University Park Press.

    Google Scholar 

  11. Bryan-Brown, C. W., and Shoemaker, W. C. (1973). Acute respiratory failure after trauma and surgery. Semin. Drug Treat. 5:269.

    Google Scholar 

  12. Cady, L. D., Weil, M. H., Afifi, A. A., Michaels, S. F., Liu, V. Y. Shubin, H. (1973). Quantitation of severity of critical illness with special reference to lactate. Crit. Care Med. 7:75–80.

    Article  Google Scholar 

  13. Chatterjee, K., Parmley, W. W., Ganz, W., Forrester, J., Walinsky, T., Crexells, C., and Swan, H. J. C. (1974). Hemodynamic and metabolic responses to vasodilator therapy in acute myocardial infarction. Circulation 45:1183–1193.

    Google Scholar 

  14. Cohen, P. J., Alexander, S. C., Smith, T. C., Reivich, M., and Wollman, H. (1967). Effects of hypoxia and normocarbia on cerebral blood flow and metabolism in conscious man. J. Appl. Physiol. 25:183–189.

    Google Scholar 

  15. da Luz, P., Weil, M. H., Cavanilles, J., and Michaels, S. (1975). Oxygen delivery, anoxic metabolism and P50 in acute myocardial infarction and shock. Am. J. Cardiol. 36:2, 148–154.

    Article  PubMed  Google Scholar 

  16. Finch, C. A., and Lenfant, C. (1972). Oxygen transport in man. New Engl. J. Med. 286:401.

    Article  Google Scholar 

  17. Franciosa, J. A., Guiha, N. H., Limas, C. J., Rodriguera, E., and Cohn, J. N. (1972). Improved left ventricular function during nitroprusside infusion in acute myocardial infarction. Lancet 7:650.

    Article  Google Scholar 

  18. Ganz, W., Donoso, R., Marcus, H., and Swan, H. J. C. (1972). Coronary hemodynamics and myocardial oxygen metabolism. Circulation 45:763.

    PubMed  CAS  Google Scholar 

  19. Grenvik, A. (1966). Respiratory, circulatory and metabolic effects of respirator treatment: a clinical study in postoperative thoracic surgical patients. Acta Anaesthesiol. Scand. (Suppl.) XIX.

    Google Scholar 

  20. Guyton, A. C., Jones, C. E., and Coleman, T. G. (1973). Circulatory Physiology: Cardiac Output and its Regulation. Philadelphia: Saunders.

    Google Scholar 

  21. Hunter, J. (1776). Proposals for the recovery of people apparently drowned. Phil. Trans. Roy. Soc. (Lond.) 66:412.

    Article  Google Scholar 

  22. Larson, C. P., Jr., Ehrenfeld, W. K., Wade, J. G., and Wylie, E. J. (1967). Jugular venous oxygen saturation as an index of adequacy of cerebral oxygenation. Surg. 62:31–39.

    Google Scholar 

  23. Laver, M. B. (1974). The arthurian legend. Anesthesiol. 40:523–524.

    Article  CAS  Google Scholar 

  24. Lipton, B., Toth, A., and Jacobson, J. H. (1973). The hyperbaric changer and pulmonary oxygen toxicity: a clinical and pathological study. Mt. Sinai J. Med. 40:1.

    Google Scholar 

  25. Masters, T. N., Harbol, N. B., and Hall, D. G. (1974). Beneficial effects of methylprednisolone sodium succinate (MPSS) with acute myocardial infarction (abstr.). Circulation 49/50:Suppl. III–119.

    Google Scholar 

  26. McConn, R., and Del Guercio, L. R. M. (1970). Respiratory function of blood in the acutely ill patient and the effect of steroids. Ann. Surg. 774:436–450.

    Google Scholar 

  27. Morrison, J., Maley, T., Reduto, L., Victa, C., Pyros, I., Brandow, J., and Gulota S. (1975). Effect of methylprednisolone on predicted myocardial infarction size in man. Crit. Care Med. 5:94–102.

    Article  Google Scholar 

  28. Mueller, H. S. (1975). Personal communication.

    Google Scholar 

  29. Mueller, H., Ayres, S. M., Gregory, J. J., Gianelli, S., and Grace, W. J. (1970). Hemodynamics, coronary blood flow and myocardial metabolism in coronary shock: Response to 1-norepinephrine and isoproterenol. J. Clin. Invest. 49:1885.

    Article  PubMed  CAS  Google Scholar 

  30. Mueller, H. S., Ayres, S. M., Religa, A., and Evans, R. G. (1974). Propranalol in the treatment of acute myocardial infarction. Circulation 49:1078–1087.

    PubMed  CAS  Google Scholar 

  31. Nunn, J. F., and Freeman, J. (1964). Problems of oxygenation and oxygen transport during haemorrhage. Anaesthesia 79:206–216.

    Article  Google Scholar 

  32. Peirce, E. C., Bryan-Brown, C. W., Lukban, S. B., Jacobson, J. H., and Rothschild, J. J. (1973). The use of hyperbaric oxygenation in conjunction with membrane perfusion for respiratory insufficiency. Mt. Sinai J. Med. 40:228.

    Google Scholar 

  33. Peters, J. P., and Van Slyke, D. D. (1932). Quantitative Clinical Chemistry. Vol. II, Baltimore: Williams and Wilkins, 1932.

    Google Scholar 

  34. Pontopiddan, H., Geffin, B., and Lowenstein, E. (1972). Acute respiratory failure in the adult. New Engl. J. Med. 287:690, 743, and 799.

    Article  Google Scholar 

  35. Priestly, J. (1777). Experiments and observations on different kinds of air. London.

    Google Scholar 

  36. Shatney, C. H., and Lillehei, R. C. (1974). Effects of methylprednisolone on myocardial infarct volume (abstr.) Circulation 49/50: Suppl. III–205.

    Google Scholar 

  37. Shell, W. E., Eshani, A. A., and Sobel, B. E. (1973). Reduction of infarct size in hypertensive patients with acute myocardial infarction. J. Clin. Invest. 52:76a.

    Article  Google Scholar 

  38. Siegel, J. H., Farrell, E. J., Goldwyn, R. M., and Friedman, H. P. (1972). Myocardial function in human septic shock states. In: Forscher, B. K., Lillehei, R. C., and Stubbs, S. S. (eds.), Shock in Low and High-Flow States. Amsterdam: Excerpta Medica, pp. 250–262.

    Google Scholar 

  39. Suter, P. M., Fairley, H. B., and Isenberg, M. D. (1975). Optimum end-respiratory airway pressure in patients with acute pulmonary failure. New Engl. J. Med 292:284.

    Article  PubMed  CAS  Google Scholar 

  40. Valeri, C. R., Zaroulis, C. G., and Fontier, N. L. (1972). Peripheral red cells as a functional biopsy to determine tissue oxygen tension. In Rorth, M., and Astrup, P. (eds.), Symposium IV. New York: Academic, p. 650.

    Google Scholar 

  41. Vyden, J. K., Nagasawa, K., Rabinowitz, B., Parmley, W. W., Tomada, H., Corday, E., and Swan, H. J. C. (1974). Effects of methylprednisolone administration in acute myocardial infarction. Am. J. Cardiol. 34:611–686.

    Google Scholar 

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Authors and Affiliations

  1. Departments of Anesthesiology and Surgery, Mount Sinai School of Medicine, City University of New York, New York, USA

    Christopher W. Bryan-Brown M.D.

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  1. Christopher W. Bryan-Brown M.D.
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© 1978 Springer-Verlag New York Inc.

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Bryan-Brown, C.W. (1978). Tissue Blood Flow and Oxygen Transport in Critically Ill Patients. In: Critical Care Medicine Manual. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-9932-5_26

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  • DOI: https://doi.org/10.1007/978-1-4612-9932-5_26

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-9934-9

  • Online ISBN: 978-1-4612-9932-5

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