Techniques for Establishing Appropriate Dose Regimens of Digitalis

  • Roger W. Jelliffe


Much recent attention has been directed to the problem of bioavailability. While oral digitoxin appears to be essentially completely absorbed [28], the bioavailability of oral digoxin appears to be somewhere between 85% [3–5] and 50% [7]. Other digoxin preparations may be even less well absorbed. Because of this, parenteral doses of digoxin probably should be reduced to 50–85% of the corresponding oral dose when using oral digoxin of good bioavailability, while little or no such reduction appears necessary for digitoxin.


Renal Function Computer Group Advance Planning Digitalis Glycoside Digitalis Toxicity 
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Copyright information

© Springer-Verlag New York Inc. 1978

Authors and Affiliations

  • Roger W. Jelliffe
    • 1
  1. 1.University of Southern California, School of MedicineLos AngelesUSA

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