Techniques for Establishing Appropriate Dose Regimens of Digitalis

  • Roger W. Jelliffe

Abstract

Much recent attention has been directed to the problem of bioavailability. While oral digitoxin appears to be essentially completely absorbed [28], the bioavailability of oral digoxin appears to be somewhere between 85% [3–5] and 50% [7]. Other digoxin preparations may be even less well absorbed. Because of this, parenteral doses of digoxin probably should be reduced to 50–85% of the corresponding oral dose when using oral digoxin of good bioavailability, while little or no such reduction appears necessary for digitoxin.

Keywords

Toxicity Catheter Creatinine Titration Streptomycin 

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Copyright information

© Springer-Verlag New York Inc. 1978

Authors and Affiliations

  • Roger W. Jelliffe
    • 1
  1. 1.University of Southern California, School of MedicineLos AngelesUSA

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