Skip to main content
SpringerLink
Log in

The experimental effects of prostaglandin E1 on small vessel patency

  • Chapter
Microvascular Anastomoses for Cerebral Ischemia

  • 65 Accesses

Abstract

In the hands of skilled microsurgeons a patency rate close to 90% can be expected in the surgical anastomosis of 1.0-mm vessels. Considering today’s instruments and techniques, however, if microsurgery is to progress to areas of new application (such as an occipital artery-posterior fossa bypass) several factors need to be overcome, one of the more important ones being consistent patency rates in vessels of 0.5-mm diameter.(1)

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Acland R. Signs of patency in small vessel anastomosis. Surgery 72:744, 1972

    PubMed  CAS  Google Scholar 

  2. Acland R. Thrombus formation in microvascular surgery. Surgery 73:766, 1973

    PubMed  CAS  Google Scholar 

  3. Acland R: Prevention of thrombus in microvascular surgery by the use of magnesium sulphate. Br J Plast Surg 25:292, 1972

    Article  PubMed  CAS  Google Scholar 

  4. Arfors KE: Counteraction of platelet activity at sites of laser-induced endothelial trauma. Br Med J 4:430, 1968

    Article  PubMed  CAS  Google Scholar 

  5. Arfors KE, Dahl DP, Engeset J, et al: In vivo quantitation of platelet activity using biolaser-induced endothelial injury. 5th European Conference on Microcirculation. Bibl Anat 10:502, 1969

    PubMed  CAS  Google Scholar 

  6. Ball G, Brereton G, Ireland D, et al: Effect of prostaglandin E1 alone and in combination with theophylline or aspirin on collagen-induced platelet aggregation and on platelet nucleotides including adenosine 3,5-cyclic monophosphate. Biochem J 120:709, 1970

    PubMed  CAS  Google Scholar 

  7. Bergström S: Isolation structure and action of the prostaglandins. In Nobel Symposium 2, Prostaglandins. S, Sammuelson B (eds): Bergström 1967, p. 21 Stockholm.

    Google Scholar 

  8. Bergström S, Carlson LA, Ekelund L, et al: Cardiovascular and metabolic response to infusions of prostaglandin E1 and to simultaneous infusions of noradrenaline and prostaglandin E1 in man. Acta Physiol Scand 64:332, 1965

    Article  PubMed  Google Scholar 

  9. Bergström S, Duner H, von Euler US, et al: Observations on the effects of infusion of prostaglandin E1 in man. Acta Physiol Scand 45:145, 1959

    Article  PubMed  Google Scholar 

  10. Berman HJ, Tangen O, Ausprunk D: Prostaglandin E1 inhibition of aggregation of hamster platelets. 5th European Conference on Microcirculation. Bib Anat 10:507, 1969

    CAS  Google Scholar 

  11. Born GVR: Observations on the rapid morphological reaction of platelets to aggregating agents. Ser Haemetol 3(4): 114, 1970

    CAS  Google Scholar 

  12. Born GVR: Platelets in thrombogenesis. Mechanism and inhibition of platelet aggregation. Ann Coll Surg Engl 36:200, 1965

    CAS  Google Scholar 

  13. Boullin DJ, Green AR, Price KS: The mechanism of ADP-induced platelet aggregation binding to platelet receptors and inhibition of binding and aggregation by prostaglandin E1. J Physiol 221:415, 1972

    PubMed  CAS  Google Scholar 

  14. Bousser M: Effects of combined prostaglandin E1 and aspirin on experimental arterial thrombosis in rabbits. Biomedicine 19:90, 1973

    PubMed  CAS  Google Scholar 

  15. Brodie GN, Baeuziger N, Chase L: The effects of thrombin on adenyl cyclase activity and a membrane protein from human platelets. Clin Invest 51:81, 1972

    Article  CAS  Google Scholar 

  16. Butcher RW: Prostaglandins and cyclic-AMP. In Greengard P, Costa E (eds): Advances in Biochemical Psychopharmacology, Vol. 3. 1970, p. 173

    Google Scholar 

  17. Carlson LA, Ekelund L, Orö L: Clinical and metabolic effects of different doses of prostaglandin E1 in Man. Acta Med Scand 183:423, 1968

    Article  PubMed  CAS  Google Scholar 

  18. Carlson LA, Irion E, Orö L: Effect of infusion of prostaglandin E1 on the aggregation of blood platelets in man. Life Sci 7:85, 1968

    Article  PubMed  CAS  Google Scholar 

  19. Clausen J, Srivastava KC: The synthesis of prostaglandins in human platelets. Lipids 7(4):246, 1972

    Article  PubMed  CAS  Google Scholar 

  20. Droller MJ, Wolfe S: Thrombin-induced increase in intracellular cyclic 3’5’-adenosine monophosphate in human platelets. J Clin Invest 51:3094, 1972

    Article  PubMed  CAS  Google Scholar 

  21. Elkeles RS, Hampton JR, Harrison MJ: Prostaglandin E1 and human platelets. Lancet 2:111, 1969

    Article  PubMed  CAS  Google Scholar 

  22. Emmons PR, Hampton JR, Harrison MJ, et al: Effect of prostaglandin E1 on platelet behavior in vitro and in vivo. Br Med J 2:468, 1967

    Article  PubMed  CAS  Google Scholar 

  23. Evans G, Mustard J: Platelet-surface reaction and thrombosis. Surgery 64:273, 1968

    PubMed  CAS  Google Scholar 

  24. Glenn E, Wilks J, Bowman B: Platelets, prostaglandins, red cells, sedimentation rates, serum and tissue proteins and non-steroidal anti-inflammatory drugs. Proc Soc Exp Biol Med 141:879, 1972

    PubMed  CAS  Google Scholar 

  25. Grottenlos J, Hornstra G: The influence of prostaglandin E1 on experimental platelet aggregation in rats. In Jones JR (ed): Proceedings of the 2nd International Symposium on Atherosclerosis, Chicago, 1969. New York Heidelberg Berlin, Springer-Verlag, 1970

    Google Scholar 

  26. Hinman J: The prostaglandins. Bioscience 17:779, 1967

    Article  CAS  Google Scholar 

  27. Hornstra G: Degree and duration of prostaglandin E1-induced inhibition of platelet aggregation in the rat. Eur Pharmacol 15:343, 1971

    Article  CAS  Google Scholar 

  28. Horton EW: Hypothesis on physiological roles of prostaglandins. Physiol Rev 49:122, 1969

    PubMed  CAS  Google Scholar 

  29. Horton EW: The prostaglandins. In Staey RS, Robson JM (eds): Recent Advances in Pharmacology, 4th ed. p.186

    Google Scholar 

  30. Irion E, Blomback M: Prostaglandins in platelet aggregation. Scand J Clin Lab Invest 24:141, 1969

    Article  PubMed  CAS  Google Scholar 

  31. Jorgensen H, Sondergaard J: Vascular responses to prostaglandin E1. Acta Derm Vener. (Stockh) 53:203, 1973

    CAS  Google Scholar 

  32. Kaegi H, Pineo G, Shimizu A, et al: Arterio-venous shunt thrombosis, prevention by sulfinpyrayone. N Engl J Med 290:304, 1974

    Article  PubMed  CAS  Google Scholar 

  33. Kaley G, Weiner R: Microcirculatory studies with prostaglandin E1. In Ramwell PW, Shaw JE (eds): Prostaglandin Symposium of the Worchester Foundation for Experimental Biology. New York, Wiley Inter-science, 1968

    Google Scholar 

  34. Karim SMM (ed): Prostaglandin, Progress in Research. New York, Wiley Inter-science, 1972, p 240

    Google Scholar 

  35. Ketchum LD, Wennen WW, Masters FW, and Robinson DW: Experimental use of pluronic F68 in microvascular surgery. Plast Re-const Surg 53:288, 1974

    Article  CAS  Google Scholar 

  36. Kloeze J: Influence of prostaglandins on platelet adhesives and platelet aggregation. In Bergström S, Sammuelson B(eds): Nobel Symposium 2, Prostaglandins. Stockholm, 1967, p241

    Google Scholar 

  37. Kloeze J: Relationship between chemical structure and platelet aggregation activity of prostaglandins. Biochem Biophys Acta 187:285, 1969

    PubMed  CAS  Google Scholar 

  38. Kloeze J: Influence of prostaglandins on ADP-induced platelet aggregation. Netherlands Society for Physiology and Pharmacology Meeting, April 6, 1967

    Google Scholar 

  39. Kloeze J: Influence of Prostaglandins E1 and E2 on coagulation of rat blood. Experientia 26:307, 1970

    Article  PubMed  CAS  Google Scholar 

  40. Kluge TH, et al: Thrombosis prophylaxis with dextran and warfarin in vascular operations. Surg Gynecol Obstet 135:941, 1972

    PubMed  CAS  Google Scholar 

  41. Lee J, et al: Prostaglandins as therapeutic agents. Arch Intern Med 131:294, 1973

    Article  PubMed  CAS  Google Scholar 

  42. Marquis N, Becker J, Vigdahl R: Platelet aggregation and epinepherine-induced decrease in cyclic-AMP synthesis. Biochem and Biophys Res Commun 39:783, 1970

    Article  CAS  Google Scholar 

  43. Marquis N, Vigdahl R, Tavorina P: Biochemical role of prostaglandin E1 in the inhibition of platelet aggregation. Second International Symposium on Atherosclerosis, Chicago, 1969

    Google Scholar 

  44. Marquis N, Vigdahl R, Tavorina P: Platelet aggregation regulation by cyclic-AMP and prostaglandin E1. Biochem Biophys Res Commun 36:965, 1969

    Article  PubMed  CAS  Google Scholar 

  45. Mattila S, Fogarty T: Heterologous vascular grafts as small vessel substitutes. Annales, Chir Gynaecol Fenn 62:234, 1973

    CAS  Google Scholar 

  46. Mayer J, Hammond G: Dipyridamole and aspirin tested against an experimental model of thrombosis. Ann Surg 178:108, 1973

    Article  PubMed  CAS  Google Scholar 

  47. Mills D, Smith J: The control of platelet responsiveness by agents that influence cyclic-AMP metabolism. Ann NY Acad Sci 201:391, 1972

    Article  PubMed  CAS  Google Scholar 

  48. Mills D, Smith J: The influence of platelet aggregation of drugs that affect the accumulation of adenosine 3′,5′ cyclic monophosphate in platelets. Biochem J 121:185, 1971

    PubMed  CAS  Google Scholar 

  49. Mustard J: Platelets, drugs, and Thrombosis. CMAJ 108:443, 1973

    Google Scholar 

  50. Mustard J, Packham M: Thromboembolism. A manifestation of the response of blood injury. Circulation 42:1, 1970

    PubMed  CAS  Google Scholar 

  51. Mustard JF, Rowsell HC, Smythe HA: The effect of sulfinpyrazone on platelet economy and thrombosis formation in rabbits. Blood 29:859, 1967

    PubMed  CAS  Google Scholar 

  52. Nakano T: Effects of prostaglandins E1, A1, F2 on the coronary and peripheral circulation. Proc Soc Exp Biol Med 127:1160, 1968

    PubMed  CAS  Google Scholar 

  53. Nomoto H, Buncke HJ, Chater NL: Improved patency rates in microvascular surgery when using magnesium sulfate and a silicone rubber vascular cuff. Plast Reconstr Surg 54:157, 1974

    PubMed  CAS  Google Scholar 

  54. O’Brien J, Henderson P, Bennett RC, Crock GW: Microvascular surgical techniques. Med J Aust 1:722, 1970

    PubMed  Google Scholar 

  55. O’Brien J, Tulevski V, Etherington M, Madgwick T: Platelet function studies before and after operation and the effect of post-operative thrombosis. J Lab Clin Med 83:342 1974

    PubMed  Google Scholar 

  56. Pelofsky S, Jacobson E, Fisher R: Effects of prostaglandin E1 on experimental cerebral vasospasm. J Neurosurg 36:634, 1972

    Article  PubMed  CAS  Google Scholar 

  57. Pickles V: Prostaglandins. Nature 224:221, 1969

    Article  PubMed  CAS  Google Scholar 

  58. Salzman E: Cyclic AMP and platelet function. N Engl J Med 286:358, 1972

    Article  PubMed  CAS  Google Scholar 

  59. Salzman E, Levine L: Cyclic 3’,5’-adenosine monophosphate in human blood platelets. J Clin Invest 50:131, 1971

    Article  PubMed  CAS  Google Scholar 

  60. Silver MF, et al: Human blood prostaglandins. Formation during clotting. Prostaglandins 1:429, 1972

    Article  PubMed  CAS  Google Scholar 

  61. Smith E, McMorrow J, Covino B, et al: Studies on the vasodilator action of prostaglandin E1. In Ramwell PW, Shaw JE (eds): Prostaglandin Symposium of the Worchester Foundation for Experimental Biology. New York, Wiley Interscience 1968, p 259

    Google Scholar 

  62. Smith J, Ingerman C, Kocsis JJ, Silver MJ: Formation of prostaglandins during the aggregation of human blood platelets. J Clin Invest 52:965, 1973

    Article  PubMed  CAS  Google Scholar 

  63. Smythe H, Ogryzlo MA, Murphy EA, et al: The effect of sulfinpyrazone on platelet economy and blood coagulation in man. Can Med Assoc J 92:818, 1965

    PubMed  CAS  Google Scholar 

  64. Sondergaard J, Helin P, Jorgensen H: Human cutaneous inflammation induced by prostaglandin E1. J Pathol 109:239, 1973

    Article  PubMed  CAS  Google Scholar 

  65. Steiner L, Forster D, Bergvall U, et al: Effect of prostaglandin E1 on cerebral circulatory disturbances following subarachnoid haemorrhage in man. Neuroradiology 4:409, 1972

    Article  Google Scholar 

  66. Tuttle R, Skelly M: Interactions of prostaglandin E1 and ouabain on Contractility of isolated rabbit atria and intracellular cation concentration. In Ramwell S, Shaw JE (eds): Prostaglandin Symposium of the Worchester Foundation for Experimental Biology. New York, Wiley Inter-science 1968, p 309

    Google Scholar 

  67. Van Crevald S, Pascha CN: Influence of the prostaglandins E1 and E2 on aggregation of blood platelets. Nature 218:316, 1968

    Article  Google Scholar 

  68. Van Crevald S, Pascha CN: Abnormality in the aggregation of blood platelets in various morbid conditions and the influence of prostaglandins upon this abnormality. Thromb Diath Haemorrh 20:180, 1968

    Google Scholar 

  69. Vigdahl R, Marquis N, Tavormina P: Platelet aggregation, Adenyl Cyclase, Prostaglandin E1 and Calcium. Biochem Biophys Res Commun 37:409, 1969

    Article  PubMed  CAS  Google Scholar 

  70. Viguera M, Sunahara F: Microcirculatory effects of prostaglandins. Can J Physiol Pharmacol 47:627, 1969

    Article  PubMed  CAS  Google Scholar 

  71. Weeks J, Sekhar N, Ducharme D: Relative activity of prostaglandins E1, A1, E2, and A2 on lipolysis, platelet aggregation, smooth muscle and the cardiovascular system. J Pharm Pharmacol 21:103, 1969

    Article  PubMed  CAS  Google Scholar 

  72. Wolfe S, Shulman N: Adenyl cyclase activity in human platelets. Biochem Biophys Res Commun 35:266, 1969

    Article  Google Scholar 

Download references

Authors
  1. Roderick G. Lamond
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Norman L. Chater
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Neurosurgery, Albert Einstein College of Medicine, Montifiore Hospital Medical Center, Bronx, New York, 10461, USA

    Jack M. Fein

  2. Division of Neurological Surgery, Loyola University Medical Center, Maywood, Illinois, 60153, USA

    O. Howard Reichman

Rights and permissions

Reprints and permissions

Copyright information

© 1978 Springer-Verlag New York Inc.

About this chapter

Cite this chapter

Lamond, R.G., Chater, N.L. (1978). The experimental effects of prostaglandin E1 on small vessel patency. In: Fein, J.M., Reichman, O.H. (eds) Microvascular Anastomoses for Cerebral Ischemia. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-9911-0_6

Download citation

  • DOI: https://doi.org/10.1007/978-1-4612-9911-0_6

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-9913-4

  • Online ISBN: 978-1-4612-9911-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation