Microneurosurgical arterial anastomoses in patients with prolonged reversible ischemic neurologic deficits (PRIND)

  • Otmar Gratzl
  • Peter Schmiedek


During the first symposium on extracranial-intracranial anastomoses in Loma Linda, California,(1) there was almost general agreement that this operation should be performed as a prophylactic measure in patients with a history of transient ischemic attacks (TIA). That this clinical condition still represents the best indication is well supported by an up-to-date review of our own series including 62 operated cases. Those patients with episodes of focal cerebral dysfunction of vascular origin lasting for no longer than 24 hours do show the most promising postoperative results, according to a long-term follow-up study. In order to analyze the therapeutic effect of the microneurosurgical anastomosis on brain blood flow a topical and quantitative evaluation has been carried out. For this purpose the data of clinical investigation, angiography, and measurement of regional cerebral blood flow (rCBF)—were collected and compared for the pre- and postoperative situation.


Middle Cerebral Artery Regional Cerebral Blood Flow Complete Restoration Middle Cerebral Artery Territory Brain Blood Flow 
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  1. 1.
    Austin GM: Microneurosurgical Anastomoses for Cerebral Ischemia. Proceedings of the First International Symposium in Loma Linda, 1972. Springfield, Ill, Thomas, 1976Google Scholar
  2. 2.
    Loeb C: Cited by Meyer JS: Summary of the 6th Salzburg conference on cerebral vascular disease. Stroke 4:2, 1973Google Scholar

Copyright information

© Springer-Verlag New York Inc. 1978

Authors and Affiliations

  • Otmar Gratzl
  • Peter Schmiedek

There are no affiliations available

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