Temperature-Sensitive Viruses: Possible Role in Chronic and Inapparent Infections
For the last 5 years my colleagues and I have been working on cell culture models of persistent viral infections. Currently, our hypothesis concerns the establishment and maintenance of certain persistent infections. We believe that in the process of infection with wild-type (wt) virulent viruses that later lead to persistent infection there is frequently a selection of tempera- ture-sensitive (ts) virus mutants uniquely suited to maintain the persistent infection.
KeywordsSarcoma Interferon Encephalitis Measle Stomatitis
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