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Carbon Dioxide and Metabolic Regulations pp 107–117Cite as

Mechanisms of Carbon Dioxide and pH Effects on Metabolism

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Part of the book series: Topics In Environmental Physiology And Medicine ((TEPHY))

Abstract

The physiological effects of acidemia are well established. It depresses the functional activity of all vital organs. The cardiovascular system is primarily affected (CLOWES et al. [1961]). Both cardiac conduction and the contractile force of the myocardium are depressed and there is vasodilatation in the peripheral circulation and cerebral vessels. By contrast, vasoconstriction develops in the lung vasculature. In the liver enzymatic activity is generally depressed. Acidemia has a thromboplastic effect and increases coagulation, contributing to intravascular clotting, as described by Hardaway [1966].

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Author information

Authors and Affiliations

  1. College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, New York, 10632, USA

    Gabriel G. Nahas

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  1. Gabriel G. Nahas
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Editors and Affiliations

  1. College of Physicians and Surgeons, Columbia University, New York, New York, USA

    Gabriel Nahas

  2. Submarine Medical Research Laboratory, Groton, Connecticut, USA

    Karl E. Schaefer

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© 1974 Springer-Verlag New York Inc.

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Nahas, G.G. (1974). Mechanisms of Carbon Dioxide and pH Effects on Metabolism. In: Nahas, G., Schaefer, K.E. (eds) Carbon Dioxide and Metabolic Regulations. Topics In Environmental Physiology And Medicine. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-9831-1_9

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  • DOI: https://doi.org/10.1007/978-1-4612-9831-1_9

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-9833-5

  • Online ISBN: 978-1-4612-9831-1

  • eBook Packages: Springer Book Archive

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