Abstract
The extravascular extracellular compartment of the cerebral fluids consists of the cerebral interstitial fluid (cISF) and of the cerebrospinal fluid (CSF). Both these fluids are continuously formed from, and returned to, the blood plasma (DAVSON [1967]). The rate of formation and bulk absorption of CSF is slow, about 0.5% of its total volume per minute (HEISEY et al. [1962]). In cISF the turnover is probably faster (FENCL et al. [1966]). CSF in the ventricles is separated from cISF by the ependyma; on the outer surface of the brain the separation between CSF and cISF is formed by pia-glia. Both these boundaries permit exchange by free diffusion of even large molecules, between cISF and the CSF in large cerebral cavities (BRIGHTMAN et al. [1970]).
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Bibliography
Brightman, M. W., Reese, T. S., and Feder, N., “Assessment with the electronmicroscope of the permeability to peroxidases of cerebral endothelium and epithelium in mice and sharks.” In Capillary permeability. C. CroneN. A. Lassen, eds. Copenhagen: Munksgaard (1970).
Davson, H., Physiology of the cerebrospinal fluid. London: J. A. Churchill (1967).
Fencl, V., “Distribution of H+ and HCO3” in cerebral fluids.” In Ion homeostasis of the brain. B. K. Siesjö S. C. Sørensen, eds. Copenhagen: Munksgaard (1971).
Fencl, V., Miller, T. B., and Pappenheimer, J. R. “Studies on the respiratory response to disturbances of acid-base balance, with deductions concerning the ionic composition of cerebral interstitial fluid.” Am. J. Physiol. 210:459–72 (1966).
Fencl, V., Vale, J. R., and Broch, J. A. “Respiration and cerebral blood flow in metabolic acidosis and alkalosis in humans.” J. Appl. Physiol. 27:67–76 (1969).
Heisey, R. S., Held, D., and Pappenheimer, J. R. “Bulk flow and diffusion in the cerebrospinal fluid system of the goat.” Am. J. Physiol. 203:775–781 (1962).
Held, D., Fencl., V., and Pappenheimer, J. R. “Electrical potential of cerebrospinal fluid.” J. Neurophysiol. 27:942–59 (1964).
Mines, A. H., and Sørensen, S. C. “Changes in the electrochemical potential difference for HCO3 − between blood and cerebrospinal fluid, and in cerebrospinal fluid lactate concentration during isocarbic hypoxia.” Acta Physiol. Scand. 81:225–33 (1971).
Mitchell, R. A., Carman, C. T., Severinghaus, J. W., Richardson, B. W., Singer, M. M., and
Shnider, S. “Stability of cerebrospinal fluid in chronic acid-base disturbances in blood.” J. Appl. Physiol. 20:443–52 (1965).
Pontén, U., and Siesjö, B. K. “Gradients of CO2 tensions in the brain.” Acta Physiol. Scand. 67:129–40 (1966).
Severinghaus, J. W. “Electrochemical gradients for hydrogen and bicarbonate ions across the blood-CSF barrier in response to acid—base balance changes. In Cerebrospinal fluid and the regulation of ventilation. C. M. Brooks, F. F. Kao, and B. B. Lloyd, eds. Oxford: Blackwell (1965).
Siesjö, B. K., and Kjällquist, Å. “A new theory for the regulation of the extracellular in the brain.” Scand. J. Clin. Lab. Med. 24:1–9 (1969).
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© 1974 Springer-Verlag New York Inc.
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Fencl, V. (1974). Carbon Dioxide in Cerebral Extracellular Fluids. In: Nahas, G., Schaefer, K.E. (eds) Carbon Dioxide and Metabolic Regulations. Topics In Environmental Physiology And Medicine. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-9831-1_22
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DOI: https://doi.org/10.1007/978-1-4612-9831-1_22
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