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Quantification of Plasma Glucagon Immunoreactive Components in Normal and Hyperglucagonemic States

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Book cover GLUCAGON: Its Role in Physiology and Clinical Medicine

Abstract

Chromatography of human and dog plasma on Bio Gel P-30 columns revealed the presence of as many as four glucagon fractions reacting with a “pancreatic glucagon-specific” antiserum (30K). These fractions have approximate molecular weights of 2000, 3500, 9000 and 160,000 and respond differently to stimulation with arginine and suppression with glucose. The 3500 and 9000 m. w. fractions account for most of the rise in plasma glucagon observed in chronic hyperglucagonemic states, such as cirrhosis of the liver, diabetes, phlorizin-induced hypoglycemia, renal failure, pancreatectomy, and glucagonoma. It is possible that the immunoreactive forms larger than pancreatic glucagon (3500 m. w.) may represent biosynthetic precursors and that those of smaller size may represent their metabolic products.

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Author information

Authors and Affiliations

  1. Fundacion Jimenez Diaz, Universidad Autonoma de Madrid, Madrid, Spain

    I. Valverde

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  1. I. Valverde
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Editor information

Editors and Affiliations

  1. Department of Physiology, Wayne State University School of Medicine, 48201, Detroit, Michigan, USA

    Piero P. Foà

  2. Department of Medicine, All-India Institute of Medical Sciences, 110016, New Delhi, India

    Jasbir S. Bajaj

  3. Department of Research, Sinai Hospital of Detroit, 48235, Detroit, Michigan, USA

    Naomi L. Foà

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© 1977 Springer-Verlag New York Inc.

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Valverde, I. (1977). Quantification of Plasma Glucagon Immunoreactive Components in Normal and Hyperglucagonemic States. In: Foà, P.P., Bajaj, J.S., Foà, N.L. (eds) GLUCAGON: Its Role in Physiology and Clinical Medicine. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-6366-1_6

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  • DOI: https://doi.org/10.1007/978-1-4612-6366-1_6

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-6368-5

  • Online ISBN: 978-1-4612-6366-1

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