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GLUCAGON: Its Role in Physiology and Clinical Medicine pp 459–485Cite as

Hormonal Regulation of Hepatic Protein Metabolism in the Rat In Vivo. Control by Glucagon

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Abstract

The ureogenic effect of glucagon in the rat in vivo was accompanied by a decrease in the rate of hepatic protein synthesis and by a significant and progressive increase of proteolysis, expressed as a rise in hepatic valine levels. The effect on protein synthesis was maximal five minutes after hormone administration and decreased progressively thereafter to reach control values after 20 minutes. On the contrary, ureogenesis and proteolysis increased progressively throughout the 20 minutes of the experiment suggesting a close relationship between the two processes.

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Author information

Authors and Affiliations

  1. Department of Metabolism, Instituto G. Marañón, C.S.I.C., Velazquez 144, Madrid-6, Spain

    R. Parrilla, A. Martin-Requero, J. Perez-Diaz & M. S. Ayuso-Parrilla

Authors
  1. R. Parrilla
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  2. A. Martin-Requero
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  3. J. Perez-Diaz
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  4. M. S. Ayuso-Parrilla
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Editor information

Editors and Affiliations

  1. Department of Physiology, Wayne State University School of Medicine, 48201, Detroit, Michigan, USA

    Piero P. Foà

  2. Department of Medicine, All-India Institute of Medical Sciences, 110016, New Delhi, India

    Jasbir S. Bajaj

  3. Department of Research, Sinai Hospital of Detroit, 48235, Detroit, Michigan, USA

    Naomi L. Foà

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© 1977 Springer-Verlag New York Inc.

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Parrilla, R., Martin-Requero, A., Perez-Diaz, J., Ayuso-Parrilla, M.S. (1977). Hormonal Regulation of Hepatic Protein Metabolism in the Rat In Vivo. Control by Glucagon. In: Foà, P.P., Bajaj, J.S., Foà, N.L. (eds) GLUCAGON: Its Role in Physiology and Clinical Medicine. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-6366-1_30

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  • DOI: https://doi.org/10.1007/978-1-4612-6366-1_30

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-6368-5

  • Online ISBN: 978-1-4612-6366-1

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