Abstract
The pancreas contains at least two molecular forms of glucagon. One of them behaves like true glucagon on gel filtration and radioreceptor analysis. The other has no or very low affinity for the hepatocyte receptors, contains the entire glucagon molecule elongated from the C-terminal threonine residue and may be the biosynthetic precursor of glucagon. Human and porcine gastrointestinal mucosa contain several major glucagon components, two of which have the immunologic characteristic of the pancreatic fractions. The other components, which do not cross-react with antisera specific for pancreatic glucagon, can be separated into four fractions by isoelectric focusing. Although one of these binds to glucagon receptors and has glycogenolytic activity, the physiologic role of the gut glucagons remains obscure.
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Holst, J.J. (1977). Interactions of Hepatocyte Membrane Receptors with Pancreatic and Gut Glucagon. In: Foà , P.P., Bajaj, J.S., Foà , N.L. (eds) GLUCAGON: Its Role in Physiology and Clinical Medicine. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-6366-1_21
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DOI: https://doi.org/10.1007/978-1-4612-6366-1_21
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