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GLUCAGON: Its Role in Physiology and Clinical Medicine pp 255–269Cite as

Effect of Vasoactive Intestinal Peptide (VIP) and Gastric Inhibitory Peptide (GIP) on Insulin and Glucagon Release by Perifused Newborn Rat Pancreas

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Abstract

The effect of porcine vasoactive intestinal polypeptide (VIP) and of gastric inhibitory peptide (GIP) on insulin and glucagon secretion was studied using the perifused splenic portion of the 3 day-old rat pancreas. The B cells were markedly stimulated by glucagon (50 ng/ml) in the presence of glucose (16.7 mM), indicating that this preparation was suitable for testing the endocrine response to polypeptide hormone stimulation. VIP, at the concentration of 2 ng/ml, induced the release of insulin and glucagon in the presence of either 4 mM or 16.7 mM glucose. At high glucose concentration (16.7 mM), VIP was more effective at a concentration of 10 ng/ml than at a concentration of 2 ng/ml. However, at a concentration of 50 ng/ml, the effectiveness of VIP decreased sharply.

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Author information

Authors and Affiliations

  1. Unité I.N.S.E.R.M. U.55, ERA C.N.R.S. n° 494, Hôpital Saint-Antoine, 75571, Paris Cedex 12, France

    D. Bataille, C. Jarrousse, N. Vauclin, C. Gespach & G. Rosselin

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  1. D. Bataille
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  2. C. Jarrousse
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  3. N. Vauclin
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  4. C. Gespach
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  5. G. Rosselin
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Editor information

Editors and Affiliations

  1. Department of Physiology, Wayne State University School of Medicine, 48201, Detroit, Michigan, USA

    Piero P. Foà

  2. Department of Medicine, All-India Institute of Medical Sciences, 110016, New Delhi, India

    Jasbir S. Bajaj

  3. Department of Research, Sinai Hospital of Detroit, 48235, Detroit, Michigan, USA

    Naomi L. Foà

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© 1977 Springer-Verlag New York Inc.

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Bataille, D., Jarrousse, C., Vauclin, N., Gespach, C., Rosselin, G. (1977). Effect of Vasoactive Intestinal Peptide (VIP) and Gastric Inhibitory Peptide (GIP) on Insulin and Glucagon Release by Perifused Newborn Rat Pancreas. In: Foà, P.P., Bajaj, J.S., Foà, N.L. (eds) GLUCAGON: Its Role in Physiology and Clinical Medicine. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-6366-1_19

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  • DOI: https://doi.org/10.1007/978-1-4612-6366-1_19

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-6368-5

  • Online ISBN: 978-1-4612-6366-1

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