Abstract
The dynamics as well as the magnitudes of the multiple phases of secretion of glucagon and insulin, studied in the perfused rat pancreas, failed to provide evidence for the existence of feedback relationships between the two pancreatic islet hormones. On the other hand, in response to common secretagogues, the release of glucagon, which consistently precedes that of insulin, may have a modifying influence on the function of the B cell.
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References
Fajans, S. S., Quibrera, R., Pek, S., Floyd, J. C., Jr., Christensen, H. N. and Conn, J. W. (1971): Stimulation of insulin release in the dog by a non-metabolizable amino acid. Comparison with leucine and arginine. J. Clin. Endocrinol. Metab. 33, 35–41.
Grodsky, G. M., Bennett, L. L., Smith, D. F. and Schmid, F. G. (1967): Effect of pulse administration of glucose or glucagon on insulin secretion in vitro. Metabolism 16, 222–233.
Ketterer, H., Eisentraut, A. M. and Unger, R. H. (1967): Effect upon insulin secretion of physiologic doses of glucagon administered via the portal vein. Diabetes 18, 283–288.
Müller, W. A., Faloona, G. R. and Unger, R. H. (1971): The effect of experimental insulin deficiency on glucagon secretion. J. Clin. Invest. 50, 1992–1999.
Pagliara, A. S., Stillings, S. N., Haymond, M. W., Hover, B. A. and Matschinsky, F. M. (1975): Insulin and Glucose as modulators of the amino acid-induced glucagon release in the isolated pancreas of alloxan and streptozotocin diabetic rats. J. Clin. Invest. 55, 244–255.
Pek, S., Fajans, S. S., Floyd, J. C,. Jr., Knopf, R. F. and Conn, J. W. (1969): Effects upon plasma glucagon of infused and ingested amino acids and of protein meals in man. Diabetes 18, Suppl. 1, 328.
Pek, S., Tai, T.-Y., Crowther, R. and Fajans, S. S. (1976): Glucagon release precedes insulin release in response to common secretagogues. Diabetes 25, 764–770.
Pek, S., Tai, T.-Y., Elster, A. and Fajans, S. S. (1975): Stimulation by prostaglandin E-2 of glucagon and insulin release from isolated rat pancreas. Prostanglandins 10, 493–502.
Samols, E., Marri, G. and Marks, V. (1965): Promotion of insulin secretion by glucagon. Lancet 2, 125–126.
Turner, D. S. and Mclntyre, N. (1966): Stimulation by glucagon of insulin release from rabbit pancreas in vitro. Lancet 1, 351–352.
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© 1977 Springer-Verlag New York Inc.
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Pek, S., Tai, TY. (1977). Dynamics and Interrelationships of In Vitro Secretion of Glucagon and Insulin. In: Foà, P.P., Bajaj, J.S., Foà, N.L. (eds) GLUCAGON: Its Role in Physiology and Clinical Medicine. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-6366-1_17
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DOI: https://doi.org/10.1007/978-1-4612-6366-1_17
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