Abstract
Data on the interrelationships between calcium and the secretory activity of the A cell are reviewed and discussed. It is postulated that calcium has a multiple role in the secretory activity of the pancreatic A cell. First, a cellular accumulation of calcium may mediate the glucagonotropic action of arginine and of a mixture of pyruvate, fumarate and glutamate. Second, the presence of a sufficient amount of extracellular calcium seems to be a prerequisite for the identification of certain environmental factors, especially glucose in high concentration, by the A cell. Third, under appropriate experimental conditions, e. g. during prolonged exposure to a low glucose level, the accumulation of intracellular calcium may exert a feedback inhibitory effect upon the secretory process.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Ashby, J. P. and Speake, R. N. (1975): Insulin and glucagon secretion from isolated islets of Langerhans. The effects of calcium ionophores. Biochem. J. 150, 89–96.
Devis, G., Somers, G., Van Obberghen, E. and Malaisse, W. J. (1975): Calcium antagonists and islet function. I. Inhibition of insulin release by verapamil. Diabetes 24, 547–551.
Edwards, J. C. (1973): A-cell metabolism and glucagon secretion. Postgr. Med. J. 49, 611–615.
Edwards, J. C. and Howell, S. L. (1973): Effects of vinblastine and colchicine on the secretion of glucagon from isolated guinea-pig islets of Langerhans. FEBS Letters 30, 89–92.
Fleckenstein, A. (1971): Specific inhibitors and promoters of calcium action in the excitation-contraction coupling of heart muscle and their role in the prevention or production of myocardial lesions. In: Calcium and the Heart. P. Harris and L. Opie, Eds., Academic Press, New York, pp. 135–188.
Fujimoto, W. Y. and Ensinck, J. W. (1976): Somatostatin inhibition of insulin and glucagon secretion in rat islet culture: reversal by ionophore A23187. Endocrinology 98, 259–262.
Gerich, J. E., Charles, M. A. and Grodsky, G. M. (1974): Characterization of the effects of arginine and glucose on glucagon and insulin release from the perfused rat pancreas. J. Clin. Invest. 54, 833–841.
Gerich, J. E., Frankel, B. J., Fanska, R., West, L., Forsham, P. H. and Grodsky, G. M. (1974): Calcium dependency of glucagon secretion from the in vitro perfused rat pancreas. Endocrinology 94, 1381–1385.
Hermansen, K. and Iversen, J. (1976): Calcium, glucose and glucagon release. Diabetologia 12, 398.
Leclercq-Meyer, V. and Marchand, J. (1976): Differential need for an inward calcium transport in the inhibition by glucose and stimulation by arginine of glucagon release. Studies with verapamil. Diabetologia 12, 405.
Leclercq-Meyer, V., Marchand, J., Leclercq, R. and Malaisse, W. J. (1976): Glucagon and insulin release by the in vitro perfused rat pancreas. Influence of the colloid composition of the perfusate. Dià bete Métab. 2, 57–65.
Leclercq-Meyer, V., Marchand, J. and Malaisse, W. J. (1973): The effect of calcium and magnesium on glucagon secretion. Endocrinology 93, 1360–1370.
Leclercq-Meyer, V., Marchand, J. and Malaisse, W. J. (1976): The role of calcium in glucagon release. Interactions between glucose and calcium. Diabetologia 12, 531–538.
Leclercq-Meyer, V., Rebolledo, O., Marchand, J. and Malaisse, W. J. (1975): Glucagon release: paradoxical stimulation during calcium deprivation. Science 189, 897–899.
Loewenstein, W. R. (1966): Permeability of membrane junctions. Ann. N. Y. Acad. Sci. 137, 441–472.
Lundquist, I., Fanska, R. and Grodsky, G. M. (1976): Direct calcium- stimulated release of glucagon from the isolated perfused rat pancreas and the effect of chemical sympathectomy. Endocrinology 98, 815–818.
Malaisse, W. J., Herchuelz, A., Levy, J., Somers, G., Devis, G., Ravazzola, M., Malaisse-Lagae, F. and Orci, L. (1975): Insulin release and the movements of calcium in pancreatic islets. In: Calcium Transport in Contraction and Secretion. E. Carafoli, F. Clementi, W. Drabikowski and A. Margreth, Eds. North Holland Publishing Company, Amsterdam, pp. 211–226.
Ohneda, A., Matsuda, K., Horigome, K., Ishii, S. and Yamagata, S. (1974): Effect of intrapancreatic administration of calcium upon glucagon secretion in dogs. Tohoku J. Exp. Med. 113, 301–311.
Orci, L., Blondel, B., Malaisse-Lagae, F., Ravazzola, M., Wollheim, C. and Renold, A. E. (1974): Cell motility and insulin release in monolayer cultures of endocrine pancreas. Diabetologia 382.
Pagliara, A. S., Stillings, S. N., Hover, B., Martin, D. M. and Matschinsky, F. M. (1974): Glucose modulation of amino acid-induced glucagon and insulin release in the isolated perfused rat pancreas. J. Clin. Invest. 54, 819–832.
Ravazzola, M., Malaisse-Lagae, F., Amherdt, M., Perrelet, A., Malaisse, W. J. and Orci, L. (1976): Patterns of calcium localization in pancreatic endocrine cells. J. Cell Sci. 27, 107–117.
Rocha, D. M., Faloona, G. R. and Unger, R. H. (1972): Glucagon-stimulating activity of 20 amino acids in dogs. J. Clin. Invest. 51, 2346–2351.
Somers, G., Devis, G., Van Obberghen, E. and Malaisse, W. J. (1976): Calcium antagonists and islet function. II. Interaction of theophylline and verapamil. Endocrinology 99, 114–124.
Somers, G., Devis, G., Van Obberghen, E. and Malaisse, W. J. (1976): Calcium antagonists and islet function. VI. Effect of barium. Pflügers Arch. 365, 21–28.
Weir, G. C., Knowlton, S. D. and Martin, D. B. (1974): Glucagon secretion from the perfused rat pancreas. Studies with glucose and catecholamines. J. Clin. Invest. 54, 1403–1412.
Wollheim, C. B., Blondel, B., Renold, A. E. and Sharp, G. W. G. (1976): Stimulatory and inhibitory effects of cyclic AMP on pancreatic glucagon release from monolayer cultures and the controlling role of calcium. Diabetologia 12, 269–277.
Wollheim, C. B., Blondel, B., Renold, A. E. and Sharp, G. W. G. (1976): Calcium induced glucagon release in monolayer cultures of the endocrine pancreas. Studies with ionophore A23187. Diabetologia 12, 287–294.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1977 Springer-Verlag New York Inc.
About this paper
Cite this paper
Leclercq-Meyer, V., Marchand, J., Malaisse, W.J. (1977). The Versatile Role of Calcium in Glucagon Release. In: Foà , P.P., Bajaj, J.S., Foà , N.L. (eds) GLUCAGON: Its Role in Physiology and Clinical Medicine. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-6366-1_15
Download citation
DOI: https://doi.org/10.1007/978-1-4612-6366-1_15
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4612-6368-5
Online ISBN: 978-1-4612-6366-1
eBook Packages: Springer Book Archive