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Ontogeny of the Entero-Pancreatic A Cells and of Glucagon Production

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GLUCAGON: Its Role in Physiology and Clinical Medicine

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Abstract

A review of the literature, histochemical and electron microscopic observations, radioimmunoassay and phosphorylase activation measurements indicate that the appearance of phosphorylase activity correlates with that of pancreatic glucagon secretion and is a prerequisite for the response of hepatic and cardiac glycogen to the hormone. The early appearance of glucagon in the embryonic gut suggests that this hormone may play a role in development. It is important to point out that although the gut continues to produce glucagon-like materials after birth, its ability to produce insulin is restricted to the embryonic and neonatal periods.

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Author information

Authors and Affiliations

  1. Division of Human Biology and Behaviour, Faculty of Health Sciences, University of Ife, Ile-Ife, Nigeria, W. Africa

    T. A. I. Grillo & D. L. Baxter-Grillo

Authors
  1. T. A. I. Grillo
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  2. D. L. Baxter-Grillo
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Editor information

Editors and Affiliations

  1. Department of Physiology, Wayne State University School of Medicine, 48201, Detroit, Michigan, USA

    Piero P. Foà

  2. Department of Medicine, All-India Institute of Medical Sciences, 110016, New Delhi, India

    Jasbir S. Bajaj

  3. Department of Research, Sinai Hospital of Detroit, 48235, Detroit, Michigan, USA

    Naomi L. Foà

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© 1977 Springer-Verlag New York Inc.

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Grillo, T.A.I., Baxter-Grillo, D.L. (1977). Ontogeny of the Entero-Pancreatic A Cells and of Glucagon Production. In: Foà, P.P., Bajaj, J.S., Foà, N.L. (eds) GLUCAGON: Its Role in Physiology and Clinical Medicine. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-6366-1_1

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  • DOI: https://doi.org/10.1007/978-1-4612-6366-1_1

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-6368-5

  • Online ISBN: 978-1-4612-6366-1

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