Focal flow and neuronal activity in experimental cerebral ischemia

  • W.-D. Heiss
  • A. G. Waltz
  • T. Hayakawa


The goal of surgical measures in patients with focal cerebrovascular disease is to improve flow to ischemic brain regions at an amount sufficient to restore or maintain neuronal function, thus minimizing neurologic deficits. Before this can be done sufficiently, the course of flow changes within and in the surrounding of focal ischemia and its relation to the persistence or restoration of neurologic deficits as well as to neuronal function has to be assessed. In experimental models of focal cerebral ischemia using ligation of extracranial arteries,(5,12,15) occlusion of intracranial vessels,(3,4,6,17) intravascular injection and embolization,(2,11,13) anesthesia, an open cranium, or drainage of cerebrospinal fluid during the onset of focal cerebral ischemia had an influence on clinical observations and pathophysiologic and chemical determinations. With the model used for MCA occlusion,(7) the cerebral cortex, the basal ganglia, and the internal capsula were infarcted regularly. Furthermore, the infarction can be produced easily in a waking animal with intact cranium, and the development of neurologic symptoms in relation to acute flow changes can be observed.


Middle Cerebral Artery Carotid Endarterectomy Focal Cerebral Ischemia Experimental Cerebral Ischemia Open Cranium 
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© Springer-Verlag New York Inc. 1977

Authors and Affiliations

  • W.-D. Heiss
  • A. G. Waltz
  • T. Hayakawa

There are no affiliations available

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