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In Vitro Aspects of Erythropoiesis pp 194–217Cite as

Extrarenal Erythropoietin

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Abstract

Although the kidney is clearly the major site of erythropoietin (Ep) production in the intact adult animal, evidence has steadily accumulated to indicate the existence of potent extrarenal loci of Ep biosynthesis.1,2 Thus the classic experiments of Jacobson and his group3 and Mirand et al.4 indicated that nephrectomy resulted in lowered production of Ep in rodents subjected to certain forms of hypoxia. The reduced elaboration of Ep following renal ablation cannot be attributed to the accumulation of unexcreted wastes in the renoprival state since bilateral ureteral ligation in the rat3 or implantation of the ureter into the iliac vein of the dog5 did not appreciably alter their ability to produce Ep in response to different types of hypoxia. Fried and co-workers6 and Schooley and Mahlmann7,8 noted that nephrectomized rats exposed to hypoxia produced approximately 10 to 15% of the Ep evoked in intact animals. These workers have demonstrated that a basic chemical similarity exists between exterarenal and renal Ep since anti-Ep neutralized the activity of the plasma from both sources (see refs. 2 and 9 for a more comprehensive treatment of this subject).

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References

  1. Krantz SB, Jacobson LO: Erythropoietin and the Regulation of Erythropoiesis. Chicago, University of Chicago Press, 1970.

    Google Scholar 

  2. Gordon AS: Erythropoietin, in Vitamins and Hormones. New York, Academic Press, 37:105–174, 1973.

    Google Scholar 

  3. Jacobson LO, Goldwasser E, Fried W, et al.: Role of the kidney in erythropoiesis. Nature 179: 633–634, 1957.

    Article  PubMed  CAS  Google Scholar 

  4. Mirand EA, Prentice TC, Slaunwhite WR: Current studies on the role of erythropoietin on erythropoiesis. Ann NY Acad Sci 77: 677–702, 1959.

    Article  PubMed  CAS  Google Scholar 

  5. Naets JP: in Williams PC (ed): Hormones and the Kidney. New York, Academic Press, pp. 75–86, 1963.

    Google Scholar 

  6. Fried W, Kilbridge T, Krantz S, et al.: Studies on extrarenal erythropoietin. J Lab Clin Med 73: 244–248, 1969.

    PubMed  CAS  Google Scholar 

  7. Schooley JC, Mahlmann LJ: Evidence for the de novo synthesis of erythropoietin in hypoxic rats. Blood 40: 662–610, 1972.

    Google Scholar 

  8. Schooley JC, Mahlmann LJ: Erythropoietin production in the anephric rat. I. Relationship between nephrectomy, time of hypoxic exposure, and erythropoietin production. Blood 39: 31–38, 1972b.

    Google Scholar 

  9. Gordon AS, Kaplan SM: Erythrogenin (REF), in Fisher JW (ed): Kidney Hormones, Vol II, London, Academic Press, pp. 187–229, 1977.

    Google Scholar 

  10. Gordon AS, Zanjani ED, Peterson EN, et al.: Studies on fetal erythropoiesis, in Gordon AS, Condorelli M, Peschle C (eds): First Int Conf on Hematop Regul of Erythropoesis. Milan, 111 Ponte, pp. 188–204, 1972.

    Google Scholar 

  11. Carmena AO, Howard D, Stohlman F Jr: Regulation of erythropoietin. XXII. Production in the newborn animal. Blood 32: 316–382, 1968.

    Google Scholar 

  12. Wang F, Fried W: Renal and extrarenal erythropoietin production in male and female rats of various ages. J Lab Clin Med 79: 181–186, 1972.

    PubMed  CAS  Google Scholar 

  13. Schooley JC, Mahlmann LJ: Extrarenal erythropoietin production by the liver in the weanling rat. Proc Soc Exp ti Biol Med 145: 1081–1083, 1974.

    Google Scholar 

  14. Peschle C, Marone G, Genovese A, et al.: Erythropoietin production by the liver in fetal neonatal life. Life Sci 17: 1325–1330, 1975a.

    Article  PubMed  CAS  Google Scholar 

  15. Kaplan SM, Weinberg SR, Gordon AS: Erythropoietin production in the neonatal rat. Sites of erythrogenin production. Biol Neonate 24: 145–150, 1974.

    Article  PubMed  CAS  Google Scholar 

  16. Zanjani ED, Poster J, Burlington H, et al.: Liver as the primary site of erythropoietin for-mation in the fetus. Lab Clin Med 89: 640–644, 1977.

    CAS  Google Scholar 

  17. Burke WT, Morse BG: Studies on the production and metabolism of erythropoietin in rat liver and kidney, in Jacobson LO, Doyle M (eds): Erythropoiesis. New York, Grune & Stratton, pp. 111–119, 1962.

    Google Scholar 

  18. Reissmann KR, Nomura T: Erythropoietin formation in isolated kidneys and liver, in Jacobson LO, Doyle M (eds): Erythropoiesis. New York, Grune & Stratton, 1962.

    Google Scholar 

  19. Katz R, Cooper GW, Gordon AS, et al.: Studies on the site of production of erythropoietin. Ann NY Acad Sci 149: 120–127, 1968.

    Article  PubMed  CAS  Google Scholar 

  20. Fried W: The liver as a source of extrarenal erythropoietin production. Blood 40: 611–677, 1972.

    Google Scholar 

  21. Mirand EA, Murphy GP: Renal erythropoietic (RDF) assays in anephric and intact baboons following varied erythropoietic stimulus. J Med 2: 192–200, 1971.

    PubMed  CAS  Google Scholar 

  22. Kaplan SM, Rothmann SA, Gordon AS, et al.: Extrarenal sites of erythrogenin production. Proc Soc Exptl Biol Med 143: 310–313, 1973.

    CAS  Google Scholar 

  23. Peschle C, Marone G, Genovese A, et al.: Relation between the reticuloendothelial system (RES) and extrarenal erythropoietin production, in Nakao K, Fisher JW, Takaku F (eds): Erythropoiesis: Proceedings of the 4th International Conference on Erythropoiesis. Baltimore, University Park Press, 1974.

    Google Scholar 

  24. Peschle C, Marone G, Genovese A, et al: Increased erythropoietin production in anephric rats with hyperplasia of the reticuloendothelial system induced by colloidal carbon or zymosan. Blood 47: 325–337, 1976a.

    PubMed  CAS  Google Scholar 

  25. Peschle C, Marone G, Genovese A, et al.: Hepatic erythropoietin: Enhanced production in anephric rats with hyperplasia of Kupffer cells. Br J Haematol 32: 105–111, 1976b.

    Article  PubMed  CAS  Google Scholar 

  26. Haurani FI, O’Brien R: The erythropoietic effect of a reticuloendothelial blocking agent. J Res 73: 126–133, 1973.

    Google Scholar 

  27. Carson EJ, Roy M, Naughton BA, et al.: The effect of reticuloendothelial overload on extrarenal erythrogenin and erythropoietin production. Proceedings of the 19th annual meeting. Am Soc Hematol: 107, 1976.

    Google Scholar 

  28. Joyce RA, Chervenick PA: Stimulation of granulopoiesis by liver macrophages. J Lab Clin Med 56: 112–117, 1975.

    Google Scholar 

  29. Chervenick PA, LoBuglio AF: Human blood monocytes: Stimulators of granulocyte and mononuclear colony formation in vitro. Science 778: 164–167, 1972.

    Google Scholar 

  30. Gruber DF, Zucali JR, Wlekinski J, et al.: Temporal transition in the site of rat erythropoietin production. Exp Hematol (in press).

    Google Scholar 

  31. Higgins GM, Anderson RM: Experimental pathology of the liver: Restoration of the liver of the white rat following partial surgical removal. Arch Pathol 12: 186–202, 1931.

    Google Scholar 

  32. Bucher NR: Regeneration of mammalian liver. Intern Rev Cytol 15: 245–300, 1963.

    Article  CAS  Google Scholar 

  33. Morley CG: Humoral regulation of liver regeneration and tissue growth. Persp Biol Med 17: 411–428, 1974.

    CAS  Google Scholar 

  34. Stenger RJ, Confer DB: Hepatocellular ultra-structure during liver regeneration after subtotal hepatectomy. Exp Mol Pathol 5: 455–474, 1965.

    Article  Google Scholar 

  35. Anderson WM, Grundholm A, Sells BH: Modification of ribosomal proteins during liver regeneration. Biochem Biophys Res Comm 62: 669–676, 1975.

    Article  PubMed  CAS  Google Scholar 

  36. Naughton BA, Kaplan SM, Roy M, et al.: Hepatic regeneration and erythropoietin production in the rat, in Prog 19th Ann Meet Am Soc Hematol p. 106, 1976.

    Google Scholar 

  37. Naughton BA, Kaplan SM, Roy M, et al.: Hepatic regeneration and erythropoietin production in the rat. Science 196: 301–302, 1977a.

    Article  PubMed  CAS  Google Scholar 

  38. Naughton BA, Piliero JA, Kruger RE, et al.: Age related variations in hepatic regeneration and erythropoietin production in the rat. Am J Anat 149: 431–438, 1977b.

    Article  PubMed  CAS  Google Scholar 

  39. Anagnostou A, Schade S, Barone J, et al.: Effects of partial hepatectomy on extrarenal erythropoietin production in rats. Blood 50: 457–462, 1977.

    PubMed  CAS  Google Scholar 

  40. Eränkö O: in Quantitative Methods in Histology and Microscopic Histochemistry. Boston, Little, Brown, pp. 57–73, 1955.

    Google Scholar 

  41. Edgren J, Laasonen L, Kock B, et al.: Kidney function and compensatory growth of the kidney in living kidney donors. Scand J Urol Nephrol 10: 134–136, 1976.

    Article  PubMed  CAS  Google Scholar 

  42. Millonig G: The advantages of a phosphate buffer for OsO4 solutions in fixation. J Appl Physics 32: 1637, 1961.

    Google Scholar 

  43. Camiscoli, JF, Weintraub AH, Gordon AS: Comparative assay of erythropoietin standards. Ann NY Acad Sci 749: 40–45, 1968.

    Article  Google Scholar 

  44. Becker FF, Lane BP: Regeneration of the mammalian liver I. Autophagocytosis during differentiation of the liver cell in preparation for cell division. Am J Pathol 47: 783–801, 1965.

    PubMed  CAS  Google Scholar 

  45. Bucher NR, Glinos AD: The effect of age on regeneration of rat liver. Cancer Res 70: 324–332, 1950.

    Google Scholar 

  46. Straube RL, Patt HM: Regeneration following partial hepatectomy as a function of age in the mouse. Fed Proc 20: 286, 1961.

    Google Scholar 

  47. Leong GF, Pessotti RL, Braeur RW: Liver function in regenerating rat liver. CrPO4 colloid uptake and bile flow, Am J Physiol 197: 880–886, 1959.

    Google Scholar 

  48. Grisham JW: A morphologic study of DNA synthesis and cell proliferation in regenerating rat liver: Autoradiography with thymidine-H3. Cancer Res 22: 842–849, 1962.

    PubMed  CAS  Google Scholar 

  49. Edwards JL, Koch A: Parenchymal and littoral cell proliferation during liver regeneration. Lab Invest 13: 32–43, 1964.

    PubMed  CAS  Google Scholar 

  50. Edwards JL, Smith SW, West-mark ER, et al.: Interrelations of DNA synthesis and cell division in normal and regenerating liver. Fed Proc 18: 415, 1959.

    Google Scholar 

  51. Schultze B, Oehlert W: Autoradiographic investigation of incorporation of 3H-Tdr into cells of the rat and mouse. Science 131: 737–738, 1960.

    Article  PubMed  CAS  Google Scholar 

  52. Wilson ME, Stowell RE, Yokoyama HO, et al.: Cytological changes in regenerating mouse liver. Cancer Res 79: 561–565, 1959.

    Google Scholar 

  53. Sigel B, Baldia LB, Dunn MR, et al.: Humoral control of liver regeneration. Surg Gynecol Obstet 124: 1023–1031, 1967.

    PubMed  CAS  Google Scholar 

  54. Johnson HA: Liver regeneration and the “critical mass” hypothesis. Am J Pathol 57: 1–15, 1969.

    PubMed  CAS  Google Scholar 

  55. Harkness RD: The spatial distribution of divid-ing cells in the liver of the rat after partial hepatectomy. J Physiol 116: 373–379, 1952.

    PubMed  CAS  Google Scholar 

  56. Bucher NR, Scott JF, Aub JC: Regeneration of the liver in parabiotic rats. Cancer Res 77: 457–465, 1951.

    Google Scholar 

  57. Wenneker AS, Sussman N: Regeneration of liver tissue following partial hepatectomy in parabiotic rats. Proc Soc Exptl Biol Med 76: 683–686, 1951.

    CAS  Google Scholar 

  58. Bernhard W, Rouiller C: Close topographical relationship between motochondria and ergos- toplasm of liver cells in a definite phase of cellular activity. J Biophys Biochem Cytol 2: 73–78, 1956.

    Article  PubMed  CAS  Google Scholar 

  59. Oberling C: The structure of cytoplasm. Internat Rev Cytol 8: 1–31, 1959.

    Article  CAS  Google Scholar 

  60. Bartok I, Viragh S: Zur Entwicklung und Differenzierung des Endoplasmatischen Retikulums in den Epithelizellan der Regenerierden Leber. Z Zellforsch Mikroscop Anat 65: 741–754, 1965.

    Article  Google Scholar 

  61. Naughton BA, Arce J, Liu P, et al.: Ultrastructural analysis of hematopoiesis in regenerating liver. Submitted for publication, 1977.

    Google Scholar 

  62. Silini G, Pozzi LV, Pona S: Studies on the haematopoietic stem cells of mouse fetal liver. J Embryol Exp Morph 17: 303–312, 1967.

    Google Scholar 

  63. Sjögren U: Erythroblastic islands and extramedullary erythropoiesis in chronic myeloid leukemia. Acta Haemat 55: 272–276, 1976.

    Article  PubMed  Google Scholar 

  64. MetCalf D, Moore MAS: Haematopoietic Cells. Amsterdam, North Holland Publishing, 1972.

    Google Scholar 

  65. Ben-Ishay Z: Selective eradication or rat bone marrow-erythroid cells by administration of cytosine arabinoside: Observations on resumptive phase of erythropoiesis. Scand J Haematol 74: 361–368, 1975.

    Google Scholar 

  66. Ben-Ishay Z: Reticular cells in erythroid islands: Their erythroblastophagocytic function. J Res 76: 340–346, 1974.

    Google Scholar 

  67. Stephenson JR, Axelrad AA, McLeod DL, et al.: Induction of colonies of hemoglobin-synthesizing cells by erythropoietin in vitro. Proc NAS 68: 1942–1946, 1971.

    Google Scholar 

  68. Trentin J J: Influence of hematopoietic organ stroma (hematopoietic inductive microenvironment on stem cell differentiation, in Gordon AS (ed): Regulation of Hematopoiesis. New York, Appleton-Century-Crofts, pp. 159–184, 1970.

    Google Scholar 

  69. Weis, L: The hematopoietic microenvironment of the bone marrow: An ultrastructural study of the stroma in rats. Anat ReC 186: 161–184, 1976.

    Article  Google Scholar 

  70. Hoffman J, Himes MB, Klein A, et al.: Responses of the liver to injury. AMA Arch Pathol 60: 10–18, 1955.

    PubMed  CAS  Google Scholar 

  71. Geschwind I, Alfert M, Schooley C: Liver regeneration and hepatic polyploidy in the hypo- physectomized rat. Exptl Cell Res 15: 232–235, 1958.

    Google Scholar 

  72. Talarico KS, Feller DD, Neville ED: Effects of hyperoxia and hypoxia on mitosis in the normal and regenerating rat liver. Proc Soc Exptl Biol Med 131: 430–434, 1969.

    CAS  Google Scholar 

  73. Whang KS, Fish MB: Evaluation of hepatic photoscanning with radioactive colloidal gold. J Nucl Med 6: 494–499, 1965.

    Google Scholar 

  74. Harper PV, Lanthrop KA, Jiminez F, et al.: Technetium 99m as a scanning agent. Radiology 85: 101–109, 1965.

    PubMed  CAS  Google Scholar 

  75. Croft DN: Diagnostic Uses of Radioisotopes in Medicine. London, Hospital Medical Publications, pp. 61–71, 1969.

    Google Scholar 

  76. Freeman LM, Johnson PM: Clinical Scintillation Imaging. New York Harper & Row, 1975.

    Google Scholar 

  77. Baker RR, Tohru M, Wagner HN: A quantitative method of measuring liver regeneration in dogs. J Surg Res 7: 578–590, 1967.

    Article  PubMed  CAS  Google Scholar 

  78. Leach KG, Karran SJ, Wisbey ML, et al.: In vivo assessment of liver size in the rat. J Nucl Med 16: 380–385, 1975.

    PubMed  CAS  Google Scholar 

  79. Samuels LD, Grosfeld JL: Serial scans of liver regeneration after hemi hepatectomy in children. Surg Gynecol Obstet 131: 453–457, 1970.

    PubMed  CAS  Google Scholar 

  80. Karran SJ, Leach KG, Blumgart LH: Assessment of liver regeneration in the rat using the gamma camera. J Nucl Med 15: 10–16, 1974.

    PubMed  CAS  Google Scholar 

  81. McAfee JG, Ause RG, Wagner HN: Diagnostic value of scintillation scanning of the liver. AMA Arch Int Med 116: 95–100, 1965.

    Article  CAS  Google Scholar 

  82. Uszler JM, Swanson LA: Focal nodular hyperplasia of the liver: Case report. J Nucl Med 16: 831–832, 1975.

    PubMed  CAS  Google Scholar 

  83. Staab EV, Hartman RC, Parrott JA: Liver imaging in the diagnosis of hepatic venous thrombosis in paroxysmal nocturnal hemoglobinuria. Radiology 117: 341–348, 1975.

    PubMed  CAS  Google Scholar 

  84. Spencer RP: Radionuclide liver scans in tumor detection. Cancer Suppl 37: 475–479, 1976.

    CAS  Google Scholar 

  85. Geslien GE, Pinsky SM, Roth RK, et al.: Sensitivity and specificity of /sup 99m/ Tc-sulfur colloid liver imaging in diffuse hepatocellular disease. Radiology 118: 115–119, 1976.

    PubMed  CAS  Google Scholar 

  86. Lopez-Majano V: Indications for liver scintigraphy. Int Surg 59: 362–366, 1974.

    PubMed  CAS  Google Scholar 

  87. Lowrance P, Chanutin A: The effect of partial hepatectomy on the blood volume of the white rat. Am J Physiol 135: 606–608, 1942.

    Google Scholar 

  88. Benacerraf B. Bilbey D, Biozzi G, et al.: The measurement of liver blood flow in partially hepatectomized rats. J Physiol 736: 287–293, 1957.

    Google Scholar 

  89. Saba TM: Liver blood flow and intravascular colloid clearance alterations following partial hepatectomy. J Res 7: 406–417, 1970.

    CAS  Google Scholar 

  90. MacKenzie RJ, Furnival CM, O’Keane MA, et al.: The effect of hepatic ischaemia on liver function and the restoration of liver mass after 70 per cent partial hepatectomy in the dog. Br J Surg 62: 431–437, 1975.

    Article  Google Scholar 

  91. Brauer RW, Leong GF, McElroy RF, et al.: Circulatory pathways in the rat liver as revealed by P32 chromic phosphate colloid uptake in the isolated perfused liver preparation. Am J Physiol 184: 593–598, 1956.

    PubMed  CAS  Google Scholar 

  92. Ingle DJ, Baker BL: Histology and regenerative capacity of liver following multiple partial hepatectomies. Proc Soc Exptl Biol Med 95: 813–816, 1957.

    CAS  Google Scholar 

  93. Moolten FL, Bucher NL: Regeneration of rat liver: Transfer of humoral agents by cross circulation. Science 158: 272–274, 1968.

    Article  Google Scholar 

  94. Paul D, Leffert H, Sato G, et al.: Stimulation of DNA and protein synthesis in fetal rat liver cells by serum from partially hepatectomized rats. PNAS 69: 374–377, 1972.

    Article  PubMed  CAS  Google Scholar 

  95. Morley CG, Kingdon HS: The regulation of cell growth. I. Identification and partial characterization of a DNA synthesis stimulating factor from the serum of partially hepatectomized rats. Biochem Biophys Acta 308: 260–275, 1973.

    PubMed  CAS  Google Scholar 

  96. Islami AH, Pack GT, Hubbard JC: The humoral factor in regeneration of the liver in parabiotic rats. Surg Gynecol Obstet 708: 549–554, 1959.

    Google Scholar 

  97. Rogers AE, Shaka JA, Pechet G, et al.: Absence of a bloodborne factor affecting liver regeneration in paired and triplet parabiotic rats. Fed Proc 20: 287, 1961.

    Google Scholar 

  98. Hayes DM, Tedo I, Matsushima Y: Stimulation of in vitro growth of rat liver cells with calf serum drawn following partial hepatectomy. J Surg Res 9: 133–137, 1969.

    Article  Google Scholar 

  99. Demetriou A, Seifter E, Levanson S: Effect of sera obtained from normal and partially hepatectomized rats and patients on the growth of cells in tissue culture. Surgery 76: 779–785, 1974.

    PubMed  CAS  Google Scholar 

  100. Adibi S, Paschkis KE, Cantarow A: Stimulation of liver mitosis by blood serum from hepatectomized rats. Exptl Cell Res 78: 396–398, 1959.

    Article  Google Scholar 

  101. Stich HF: Regulation of mitotic rate in mammalian organisms. Ann NY Acad Sci 90: 603–609, 1960

    Article  Google Scholar 

  102. Levi JU, Zeppa R: Source of the humoral factor that initiates hepatic regeneration. Ann Surg 174: 364–370, 1971.

    Article  PubMed  CAS  Google Scholar 

  103. Preuss HG, Terryi EF, Keller Al: Renotropic factor(s) in plasma from uninephrectomized rats. Nephron (Basel) 7: 459–470, 1970.

    Article  CAS  Google Scholar 

  104. Dicker SE, Morris C, Shipolini R: Regulation of compensatory kidney hypertrophy by its own products. J. Physiol 269: 687–706, 1977.

    PubMed  CAS  Google Scholar 

  105. Alston WC, Thomson RY: Humoral and local factors in liver regeneration. Cancer Res 23: 901–909, 1963.

    PubMed  CAS  Google Scholar 

  106. Fisher B, Szuch P, Fisher ER: Evaluation of humoral factor in liver regeneration utilizing liver transplants. Cancer Res 31: 322–330, 1971.

    PubMed  CAS  Google Scholar 

  107. Max MH, Price JB, Takeshige K, et al.: The role of factors of portal origin in modifying hepatic regeneration. J Surg Res 11: 590–593, 1972.

    Google Scholar 

  108. Thomson RY, Clarke AM: Role of portal blood supply in liver regeneration. Nature 208: 392–393, 1965.

    Article  PubMed  CAS  Google Scholar 

  109. Starzyl TE, Francavilla A, Halgrimson CG, et al.: The original hormone nature and action of hepatotrophic substances in portal venous blood. Surg Gynecol Obstet 137: 179–199, 1973.

    Google Scholar 

  110. Bollman L: Liver. Ann Rev Physiol 23: 183–206, 1961.

    Article  CAS  Google Scholar 

  111. Paschkis KE, Goddard J, Cantarow A, et al.: Stimulation of growth by partial hepatectomy. Proc Soc Exptl Biol Med 101: 184–186, 1959.

    CAS  Google Scholar 

  112. Smythe RL, Moore RO: A study of possible humoral factors in liver regeneration in the rat. Surgery 44: 561–571, 1958.

    PubMed  CAS  Google Scholar 

  113. Jackson B, Bohnel E: Effect of serum injections on body weight and liver regeneration of partially hepatectomized rats. Fed Proc 21: 301, 1962.

    Google Scholar 

  114. Leong GF, Grishom JW, Hole B: Effect of rapid “total” exchange transfusion on hepatic DNA synthesis in partially hepatectomized rats. Fed Proc 22: 192, 1963.

    Google Scholar 

  115. Pechet GS, Rogers AE, MacDonald RA: Inhibitory humoral factors and liver regeneration. Fed Proc 22: 192, 1963.

    Google Scholar 

  116. Salvatorelli G, Smith J: Effet de diverses fractions d’extraits de foie embryonnaire de poulet sur l’erythropoiese in vitro. C R Hebd Seances Acad Sci Ser D Sci Natur (Paris) 272: 869–872, 1971.

    CAS  Google Scholar 

  117. Fisher S, Roheim PS: Role of the liver in the in-activation of erythropoietin. Nature 200: 899–900, 1963.

    Article  Google Scholar 

  118. Jacobsen EM, Davis AK, Alpen EL: Relative effectiveness of phenylhydrazine treatment and hemorrhage in the production of an erythropoietic factor. Blood 11: 937–945, 1956.

    PubMed  Google Scholar 

  119. Prentice TC, Mirand EA: Effect of acute liver damage plus hypoxia on plasma erythropoietin content. Proc Soc Exptl Biol Med 95: 231–234, 1957.

    CAS  Google Scholar 

  120. Gordon AS, Zanjani ED, Zalusky R: A possible mechanism for the erythrocytosis associated with hepatocellular carcinoma in man. Blood 35: 151–157, 1970.

    PubMed  CAS  Google Scholar 

  121. Nixon RK, O’Rourke W, Rupe CE, et al.: Nephrogenic polycythemia. Arch Intern Med 106: 797–802, 1960.

    Article  PubMed  CAS  Google Scholar 

  122. Mann DL, Gallagher NI, Donati RM: Erythro-cytosis and primary aldosterism. Ann Intern Med 66: 335–340, 1967.

    PubMed  CAS  Google Scholar 

  123. Leffert H, Alexander NM, Faloona G, et al.: Specific endocrine and hormonal receptor changes associated with liver regeneration in adult rats. PNAS 72: 4033–4036, 1975.

    Article  PubMed  CAS  Google Scholar 

  124. Peschle C, Rappaport IA, Sasso GF, et al.: Mechanism of growth hormone (GH) action on erythropoiesis. Endocrinol 97: 511–517, 1972.

    Article  Google Scholar 

  125. Cater DB, Holmes BE, Nee LK, et al.: The effect of growth hormones upon cell division and nucleic acid synthesis in the regenerating liver of the rat. J Biochem 66: 482–486, 1957.

    CAS  Google Scholar 

  126. Post J, Himes MB, Klein A, et al.: Responses of the liver to injury. AMA Arch Pathol 64: 284–289, 1957.

    PubMed  CAS  Google Scholar 

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Authors
  1. Brian A. Naughton
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  2. Albert S. Gordon
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  3. Sam J. Piliero
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  4. Philip Liu
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Editors and Affiliations

  1. Bob Hipple Laboratory for Cancer Research, Sloan-Kettering Institute for Cancer Research, 1250 1st Avenue, 10021, New York, New York, USA

    Martin J. Murphy Jr. Ph. D. (Director) (Director)

  2. Istituto Patologia Medica, Nuovo Policlinico Universita di Napoli, Via S. Pancini, 80131, Napoli, Italy

    Cesare Peschle M. D.

  3. Dept. of Biology, New York University, Washington Square East, 10003, New York, New York, USA

    Albert S. Gordon Ph. D. (Research Professor) (Research Professor)

  4. Dept. of Biological Resources, Roswell Park Memorial Institute, Buffalo, New York, USA

    Edwin A. Mirand Ph. D., D. Sc. (Associate Institute Director and Head) (Associate Institute Director and Head)

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Naughton, B.A., Gordon, A.S., Piliero, S.J., Liu, P. (1978). Extrarenal Erythropoietin. In: Murphy, M.J., Peschle, C., Gordon, A.S., Mirand, E.A. (eds) In Vitro Aspects of Erythropoiesis. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-6301-2_32

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