Skip to main content
SpringerLink
Log in

Potential for Differentiation, Virus Production, and Tumorigenicity in Murine Erythroleukemic Cells Treated with Interferon

  • Chapter
In Vitro Aspects of Erythropoiesis

Abstract

Studies of erythropoiesis suffered in the past from the lack of a suitable in vitro system in which the biology of erythropoietic cells could be studied under defined conditions, on one hand, and in which mass cultures would be possible, on the other hand, so that molecular biology could also enter the picture. When Charlotte Friend showed that explants of transplantable subcutaneous tumors, originated from virus-induced murine leukemic spleens and/or livers and adapted to grow in vitro, consistently gave rise to tissue culture lines able to differentiate only along the erythroid pathway, the first step had been made toward this goal.1,2 There were, however, two unfortunate reasons why studies of this system were hindered for some time: (a) the percentage of differentiating cells was too low to allow any molecular biology analysis, and (b) the cultured cells were not sensitive to erythropoietin, which meant that erythropoiesis in this system was not the exact counterpart of the physiological pattern. It was only a few years later that Friend cells became a most popular tool for biologists and molecular biologists engaged in studies of erythropoiesis. This was due to Charlotte Friend’s3 demonstration that the addition of dimethyl sulfoxide (DMSO) to cultures of Friend cells caused a massive shift toward more differentiated stages of erythropoiesis. Although the precise mechanism of this phenomenon is still unknown, the availability of a cell population whereby 70 to 80% of the cells would engage at will in quasiterminal erythroid differentiation immediately prompted an avalanche of studies dealing with several aspects of erythropoiesis. Temin’s4 and Baltimore’s5 discovery of reverse transcriptase made possible, in addition, in vitro synthesis of radioactive complementary DNAs (cDNAs) to a given RNA probe. In erythropoiesis this meant the synthesis of the globin cDNA,6 and thus, the possibility of exact measurements of globin mRNA amounts in the Friend system.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Friend C, Patuleia MC, De Harven E: Natl Cancer Inst Monogr 22: 505–522, 1966.

    PubMed  CAS  Google Scholar 

  2. Rossi GB, Friend C: Proc Natl Acad Sci USA 58: 1373–1380, 1967.

    Article  PubMed  CAS  Google Scholar 

  3. Friend C, Scher W, Holland JC, et al: Proc Natl Acad Sci USA 68: 378–382, 1971.

    PubMed  CAS  Google Scholar 

  4. Temin HM, Mizutani S: Nature 226: 1211–1213, 1970.

    Article  PubMed  CAS  Google Scholar 

  5. Baltimore D: Nature 226: 1209–1211, 1970.

    Article  PubMed  CAS  Google Scholar 

  6. Ross J, Ikawa Y, Leder P: Proc Natl Acad Sci USA 69: 3620–3623, 1972.

    Article  PubMed  CAS  Google Scholar 

  7. Harrison PR. In Paul J (ed): Biochemistry of Differentiation. London, MTP, in press.

    Google Scholar 

  8. Bernstein A, Hunt DM, Crichley V, et al: Cell 9: 375–381, 1976.

    Article  PubMed  CAS  Google Scholar 

  9. Rovera G, O’Brien TG, Diamond L: Proc Natl Acad Sci USA 74: 2894–2898, 1977.

    Article  PubMed  CAS  Google Scholar 

  10. Yamasaki H, Fibach E, Nudel V, et al: Proc Natl Acad Sci USA 74: 3451–3455, 1977.

    Article  PubMed  CAS  Google Scholar 

  11. Mc Clintock PR, Papaconstantinou J: Proc Natl Acad Sci USA 71: 4551–4555, 1974.

    Google Scholar 

  12. Wayne Wiens A, Mc Clintock PR, Papaconstantinou J: Biochem Biophys Res Comm 70: 824–831, 1976.

    Google Scholar 

  13. Levy J, Terada M, Rifkind RA, et al: Proc Natl Acad Sci USA 72: 28–32, 1975.

    Article  PubMed  CAS  Google Scholar 

  14. Terada M, Fried J, Nudel U, et al: Proc Natl Acad Sci USA 74: 248–252, 1977.

    Article  PubMed  CAS  Google Scholar 

  15. Leder A, Leder P: Cell 5: 319–322, 1975.

    Article  PubMed  CAS  Google Scholar 

  16. Gusella J, Geller R, Clarke B, et al: Cell 9: 221–230, 1976.

    Article  PubMed  CAS  Google Scholar 

  17. Sato T, Friend C, De Harven E: Cancer Res 37: 1402–1417, 1971.

    Google Scholar 

  18. Jasmin C, Smadja-Joffe F, Klein B, et al: Cancer Res 36: 603–607, 1976.

    PubMed  CAS  Google Scholar 

  19. Ostertag W, Pragnell IB, Krieg CF, et al: In Oncogenic Viruses and Host Genes. New York, Academic Press, in press.

    Google Scholar 

  20. Chang EH, Myers MW, Wong PKY, et al: Virology 77: 625–635, 1977.

    Article  PubMed  CAS  Google Scholar 

  21. Billiau A, Heremans H, Allen PT, et al: Virology 73: 537–542, 1976.

    Article  PubMed  CAS  Google Scholar 

  22. Pitha PM, Rowe WP, Oxman MN: Virology 70: 324–338, 1976.

    Article  PubMed  CAS  Google Scholar 

  23. Gresser I: In Cancer, A Comprehensive Treatise. New York, Plenum Press, 1978.

    Google Scholar 

  24. Youngner JS, Salvin SB: J Immunol 111: 1914–1922, 1973.

    PubMed  CAS  Google Scholar 

  25. Trinchieri G, Santoli D, Dee RR, et al: Submitted for publication.

    Google Scholar 

  26. Curtis PJ, Weisman C: J Mol Biol 106: 1061–1075, 1976.

    Article  CAS  Google Scholar 

  27. Affrabris E, Pulciani S, Rossi GB: Microbiologica, in press, 1978.

    Google Scholar 

  28. Orkin SH, Harosi FI, Leder P: Proc Natl Acad Sci USA 72: 98–102, 1975.

    Article  PubMed  CAS  Google Scholar 

  29. Chan LNL: Nature 261: 157–159, 1976.

    Article  PubMed  CAS  Google Scholar 

  30. Reuben RC, Wife RL, Breslow R, et al: Proc Natl Acad Sci USA 73: 862–867, 1976.

    Article  PubMed  CAS  Google Scholar 

  31. Hiller G, Weber K: Nature 266: 181–183, 1977.

    Article  PubMed  CAS  Google Scholar 

  32. Rossi GB, Aducci P, Gambari R, et al: Submitted for publication.

    Google Scholar 

  33. Stein G, Stein J, Thrall C, et al: In Stein GG, Kleinsmith LJ (eds): Chromosomal Proteins and their Role in the Regulation of Gene expression. New York, Academic Press, pp. 1–17, 1975.

    Google Scholar 

  34. Newman SA, Birbaum J, Yech GCT: Nature 259: 415–418, 1976.

    Article  Google Scholar 

  35. Paul J, Gillmour LS: J Mol Biol 34: 305–316, 1968.

    Article  PubMed  CAS  Google Scholar 

  36. Lunadei M, Matteucci P, Ullu E, et al: Submitted for publication.

    Google Scholar 

  37. Peterson JL, Me Conckey EH: J Biol Chem 251: 555–558, 1976.

    Google Scholar 

  38. Keppel S, Allet B, Eisen H: Proc Natl Acad Sci USA 74: 653–656, 1977.

    Article  PubMed  CAS  Google Scholar 

  39. Lau AF, Ruddon RW: Exp Cell Res 107: 35–46, 1977.

    Article  PubMed  CAS  Google Scholar 

  40. Rossi GB, Matarese GP, Grappelli C, et al: Nature 267: 50–52, 1977.

    Article  PubMed  CAS  Google Scholar 

  41. Matarese GP, Rossi GB: J Cell Biol, 75: 344–354, 1977.

    Article  PubMed  CAS  Google Scholar 

  42. Luftig RB, Conscience JF, Skoultchi A, et al: J Virol 23: 799–810, 1977.

    PubMed  CAS  Google Scholar 

  43. Gusella JF, Housman D: Cell 8: 263–269, 1976.

    Article  PubMed  CAS  Google Scholar 

  44. Rossi GB, Dolei A, Cioé L, et al: Texas Reps on Biol and Med. Interferon Issue. S Baron and F Dianzani, in press, 1977.

    Google Scholar 

  45. Rossi GB, Dolei A, Cioé L, et al: Oncogenic Viruses and Host Genes. Academic Press, New York, in press, 1977.

    Google Scholar 

  46. Rossi GB, Dolei A, Cioé L, et al: Proc Natl Acad Sci USA 74: 2036–2040, 1977.

    Article  PubMed  CAS  Google Scholar 

  47. Farace MG, Ullu E, Fantoni A, et al: Submitted for publication.

    Google Scholar 

  48. Marku K, Dudock B: Nucleic Acid Res 1: 1385–1389, 1974.

    Article  Google Scholar 

  49. Fantoni A, Ullu E, Gambari R, et al: Ann Immunol (1st Pasteur) 127: 881–883, 1976.

    CAS  Google Scholar 

  50. Bordin S, Farace MG, Fantoni A: Biochim BiophysActa 257: 277–288, 1972.

    Google Scholar 

  51. Ramoni C, Matarese GP, Rossi GB, et al: J Gen Virol, in press, 1977.

    Google Scholar 

  52. Rossi GB, Marchegiani M, Matarese GP, et al: J Natl Cancer Inst 54: 993–996, 1975.

    PubMed  CAS  Google Scholar 

  53. Gresser I: In Klein G, Weinhouse S (eds): Advances in Cancer Research. New York, Academic Press, pp. 97–140, 1972.

    Google Scholar 

  54. Kuwata T, Fuse A, Morigana N: J Gen Virol 33: 7–15, 1976.

    Article  Google Scholar 

  55. Stewart WE II, Gosser LB, Lockart RZ Jr: J Virol 7: 792–801, 1971.

    PubMed  CAS  Google Scholar 

  56. Lindahl-Magnusson P, Leary P, Gresser I: Nature (New Biol) 237: 120–121, 1972.

    Article  CAS  Google Scholar 

  57. Fuse A, Kuwata T: J Gen Virol 32: 17–24, 1976.

    Article  Google Scholar 

  58. Macieira-Coelho A, Brouty-Boyè D, Thomas MT, et al: J Cell Biol 45: 415–419, 1971.

    Article  Google Scholar 

  59. Collyn d’Hooghe M, Brouty-Boyè D, Malaise EP, et al: Exp Cell Res 105: 73–11, 1977.

    Article  Google Scholar 

  60. Ida S, Hooks JJ, Siraganian RP, et al: J Exp Med 745: 892–899, 1977.

    Article  Google Scholar 

  61. Lindahl P, Gresser I, Leary P, et al: Proc Natl Acad Sci USA 73: 1284–1287, 1976.

    Article  PubMed  CAS  Google Scholar 

  62. Gisler RH, Lindahl P, Gresser I: J Immunol 13: 438–444, 1974.

    Google Scholar 

  63. Lindahl P, Leary P, Gresser I: Proc Natl Acad Sci USA 69: 721–727, 1972.

    Article  PubMed  CAS  Google Scholar 

  64. Nebert DW, Friedman RM: J. Virol 77: 193–197, 1973

    Google Scholar 

  65. Beck G, Poindron P, Illinger D, et al: FEBS lett 48: 297–300, 1974.

    Article  PubMed  CAS  Google Scholar 

  66. Illinger D, Coupin G, Poindron P: J Gen Virol, 1978.

    Google Scholar 

  67. Huet C, Gresser I, Bandu MT, et al: Proc Soc Exp Biol Med 147: 52–57, 1974.

    PubMed  CAS  Google Scholar 

  68. Johnson HM, Stanton GJ, Baron S: Proc Soc Exp Biol Med 154: 138–141, 1977.

    PubMed  CAS  Google Scholar 

  69. Sonnenfeld G, Mandel AD, Merigan TG: Submitted for publication.

    Google Scholar 

  70. Crosby WH, Furth FW: Blood 11: 380–385, 1956.

    PubMed  CAS  Google Scholar 

  71. Dianzani F, Baron S: Nature 257: 682–683, 1975.

    Article  PubMed  CAS  Google Scholar 

  72. Ankel H, Chany C, Galliot B, et al: Proc Natl Acad Sci USA 70: 2360–2363, 1973.

    Article  PubMed  CAS  Google Scholar 

  73. Besançon F, Ankel H: Nature 252: 478–480, 1974.

    Article  PubMed  Google Scholar 

  74. Kohn LD, Friedman RM, Holmes JM, et al: Proc Natl Acad Sci USA 73: 3695–3699, 1976.

    Article  PubMed  CAS  Google Scholar 

  75. Vengris SH, Reynolds FH Jr, Hollemberg MD, et al: Virology 72: 486–493, 1976.

    Article  PubMed  CAS  Google Scholar 

  76. Lieberman D, Voloch Z, Aviv H, et al: Mol Biol Rep 1: 477–481, 1975.

    Google Scholar 

  77. Swetly P, Ostertag W: Nature 251: 642–644, 1974.

    Article  PubMed  CAS  Google Scholar 

  78. Bourgeade MF, Chany C: Proc Soc Exp Biol Med 153: 501–504, 1976.

    PubMed  CAS  Google Scholar 

  79. Weber JM, Stewart RB: J Gen Virol 25: 363–372, 1975.

    Article  Google Scholar 

  80. Bocci V, Pacini A, Pressina GP, et al: Experientia 33: 164–165, 1977.

    Article  PubMed  CAS  Google Scholar 

  81. Stewart WE, De Clercq E, Billiau A, et al: Proc Natl Acad Sci USA 69: 1851–1854, 1972.

    Article  PubMed  CAS  Google Scholar 

Download references

Authors
  1. L. Cioé
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. Dolei
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. G. B. Rossi
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. F. Belardelli
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. E. Affabris
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. R. Gambari
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. A. Fantoni
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Bob Hipple Laboratory for Cancer Research, Sloan-Kettering Institute for Cancer Research, 1250 1st Avenue, 10021, New York, New York, USA

    Martin J. Murphy Jr. Ph. D. (Director) (Director)

  2. Istituto Patologia Medica, Nuovo Policlinico Universita di Napoli, Via S. Pancini, 80131, Napoli, Italy

    Cesare Peschle M. D.

  3. Dept. of Biology, New York University, Washington Square East, 10003, New York, New York, USA

    Albert S. Gordon Ph. D. (Research Professor) (Research Professor)

  4. Dept. of Biological Resources, Roswell Park Memorial Institute, Buffalo, New York, USA

    Edwin A. Mirand Ph. D., D. Sc. (Associate Institute Director and Head) (Associate Institute Director and Head)

Rights and permissions

Reprints and permissions

Copyright information

© 1978 Springer-Verlag New York Inc.

About this chapter

Cite this chapter

Cioé, L. et al. (1978). Potential for Differentiation, Virus Production, and Tumorigenicity in Murine Erythroleukemic Cells Treated with Interferon. In: Murphy, M.J., Peschle, C., Gordon, A.S., Mirand, E.A. (eds) In Vitro Aspects of Erythropoiesis. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-6301-2_26

Download citation

  • DOI: https://doi.org/10.1007/978-1-4612-6301-2_26

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-6303-6

  • Online ISBN: 978-1-4612-6301-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation