Abstract
Murine Friend virus-transformed cells can be induced to differentiate into erythroid cells by the addition of various agents, for example, dimethylsulfoxide (DMSO),1 other aprotic solvents,2 butyric acid,3 purines and purine analogues,4 hemin,5,6 and so forth. These processes that occur after inducer-treatment provide a useful model of erythroid cell differentiation since many erythroid-specific functions are induced such as the production of globin messenger RNA,7 the synthesis of specific red cell membrane proteins,8 as well as the de novo synthesis of heme pathway enzymes,9 finally leading to the formation of heme and hemoglobin.
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References
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Urabe, A., Murphy, M.J., Sassa, S. (1978). Studies on Erythroid Differentiation in a Wild-Type and Dimethylsulfoxide-Resistant Clones of Friend Virus-Transformed Cells: Effects of Hemin, Hemoglobin, Erythropoietin. In: Murphy, M.J., Peschle, C., Gordon, A.S., Mirand, E.A. (eds) In Vitro Aspects of Erythropoiesis. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-6301-2_24
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DOI: https://doi.org/10.1007/978-1-4612-6301-2_24
Publisher Name: Springer, New York, NY
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