Abstract
On the basis of their observations that a host develops a sensitivity directed specifically against further donations of an allograft from the first donor, Gibson and Medawar (1943) formulated the original hypothesis of acquired immunity. If a second graft from the same donor is applied, it is destroyed in an accelerated fashion, termed the “second-set phenomenon” by Medawar (1944, 1945). Whereas the primary graft of normal skin is generally rejected within 7–8 days after application, second-set grafts seldom survive beyond 5–6 days. Additional repeat-set allografts show no further shortening of the recipient’s rejection time, but are destroyed at the same rate as the secondset grafts (Lehrfeld, Taylor, and Converse 1955; Rapaport and Converse 1958) (see the section on The White Graft Reaction).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 1979 Springer-Verlag New York Inc.
About this chapter
Cite this chapter
Ballantyne, D.L., Converse, J.M. (1979). Survival and Rejection of Second-Set Skin Allografts. In: Experimental Skin Grafts and Transplantation Immunity. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-6223-7_7
Download citation
DOI: https://doi.org/10.1007/978-1-4612-6223-7_7
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4612-6225-1
Online ISBN: 978-1-4612-6223-7
eBook Packages: Springer Book Archive