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Bleomycin: Chemical, Biochemical, and Biological Aspects pp 309–323Cite as

Conjugation of Bifunctional Chelating Agents to Bleomycin for Use in Nuclear Medicine

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Abstract

The affinity of bleomycin for tumorous tissue, coupled with its ability to chelate a variety of metal ions, has aroused considerable interest in its potential as a tumor-visualizing agent. The rationale behind this has been that the bleomycin chelate of a γ-ray emitting metal ion would localize in tumor tissue in vivo; the size and location of malignant tissue could then be determined for diagnostic purposes. 57Co-bleomycin was the first bleomycin chelate to be used clinically as a tumor-locating agent(1). Because of the 270-day radioactive half-life of 57Co, several other bleomycin-metal chelates have since been investigated (see Table 1).

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Authors
  1. Claude F. Meares
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  2. Leslie H. De Remier
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  3. David A. Goodwin
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Editor information

Editors and Affiliations

  1. Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Mass., 02139, USA

    Sidney M. Hect

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© 1979 Springer-Verlag New York Inc.

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Meares, C.F., De Remier, L.H., Goodwin, D.A. (1979). Conjugation of Bifunctional Chelating Agents to Bleomycin for Use in Nuclear Medicine. In: Hect, S.M. (eds) Bleomycin: Chemical, Biochemical, and Biological Aspects. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-6191-9_23

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  • DOI: https://doi.org/10.1007/978-1-4612-6191-9_23

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-6193-3

  • Online ISBN: 978-1-4612-6191-9

  • eBook Packages: Springer Book Archive

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