Marrow Allograft Survival in W/Wv Anemic Mice: Effects on Skin Graft Survival and Effects of Preimmunization
The necessity in marrow transplantation of matching donor and recipient for the major histocompatibility locus has been well established (13,14). It is possible, however, that antigenic disparities determined by other loci are also important in marrow grafting. Thus, the W-anemic mouse recipients of marrow grafts offer a valuable method to explore this problem, because their hemopoietic systems can be completely populated (10,11) and their immunopoietic systems mostly populated (5) by grafts of histocompatible normal donor cells. This occurs without irradiation or other treatment of the recipients (reviewed in ref. 12). Thus, the immune responses of W-anemic recipients are intact, and they are as effective in skin graft rejections (6) and in life long responses to sheep erythrocytes and phytohemagglutinin (PHA) (4,9) as are the immune responses of normal mice.
KeywordsMarrow Cell Spleen Cell Skin Graft Donor Cell Marrow Graft
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