Marrow Allograft Survival in W/Wv Anemic Mice: Effects on Skin Graft Survival and Effects of Preimmunization

  • D. E. Harrison
  • L. E. Mobraaten
Conference paper
Part of the Experimental Hematology Today book series (HEMATOLOGY, volume 1979)

Abstract

The necessity in marrow transplantation of matching donor and recipient for the major histocompatibility locus has been well established (13,14). It is possible, however, that antigenic disparities determined by other loci are also important in marrow grafting. Thus, the W-anemic mouse recipients of marrow grafts offer a valuable method to explore this problem, because their hemopoietic systems can be completely populated (10,11) and their immunopoietic systems mostly populated (5) by grafts of histocompatible normal donor cells. This occurs without irradiation or other treatment of the recipients (reviewed in ref. 12). Thus, the immune responses of W-anemic recipients are intact, and they are as effective in skin graft rejections (6) and in life long responses to sheep erythrocytes and phytohemagglutinin (PHA) (4,9) as are the immune responses of normal mice.

Keywords

Filtration Leukemia Anemia Allo Erythro 

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References

  1. 1.
    Bailey, D. W. Histocompatibility associated with X-chromosome in mice. Transplantation, 1: 71, 1963.CrossRefGoogle Scholar
  2. 2.
    Bailey, D. W. Genetics of histocompatibility in mice. I. New loci and congenic lines. Immunogenetics, 2:249,Google Scholar
  3. 3.
    Harrison, D. W. Avoidance of graft versus host reactions in cured W-anemic mice. Transplantation, 22: 47, 1976PubMedCrossRefGoogle Scholar
  4. 4.
    Harrison, D. E. Genetically defined animals valuable in testing aging of erythroid and lymphoid stem cells and microenvironments. In Bergsma, D., and Harrison, D. E., eds., Genetic Effects on Aging. National Foundation Original Article Series Volume XIV, Number 1, New York: A. R. Liss, 1978, p. 187.Google Scholar
  5. 5.
    Harrison, D. E., and Astle, C. M. Population of lymphoid tissues in cured W-anemic mice by donor cells. Transplantation, 22: 42, 1976.PubMedCrossRefGoogle Scholar
  6. 6.
    Harrison, D. E., and Cherry, M. Survival of marrow allografts in W/Wv anemic mice: effect of disparity at the Ea-2 locus. Immunogenetics, 2: 219, 1975.CrossRefGoogle Scholar
  7. 7.
    Harrison, D. E., and Doubleday, J. W. Marrow allograft survival in W/Wv mice: relation to skin graft sursurvival times. Immunogenetics, 3: 289, 1976.CrossRefGoogle Scholar
  8. 8.
    Micklem, H. S., and Loutit, J. K. Tissue Grafting and Radiation. New York: Academic Press, 1966.Google Scholar
  9. 9.
    Mekori, T. and Phillips, R. A. The immune response in mice of genotype W/Wv and S1/S1d. Proc. Soc. Exp. Biol. Med., 132: 115, 1969.PubMedGoogle Scholar
  10. 10.
    Murphy, E. D., Harrison, D. W., and Roths, J,. Giant granules of beige mice: A quantitative marker for granulocytes in bone marrow transplantation. Transplantation, 15: 526, 1973.PubMedCrossRefGoogle Scholar
  11. 11.
    Russell, E. S., and Bernstein, S. E. Proof of whole-cell implant in the therapy of W-series anemia. Arch. Biochem. Biophys., 125: 594, 1968.PubMedCrossRefGoogle Scholar
  12. 12.
    Russell, E. S. Abnormalities of erythropoiesis associated with mutant genes in mice. In Gordon, A. S. ed., Regulation of Hematopoiesis. New York: Appleton Century-Crofts, 1970.Google Scholar
  13. 13.
    Snell, J. D., Dausset, J., and Nathenson, S., Histocompatibility. New York: Academic Press, 1976.Google Scholar
  14. 14.
    Thomas, E. D., Fefer, A., Buckner, C. D., and Storb, R. Current status of bone marrow transplantation for aplastic anemia and acute leukemia. Blood, 49: 611, 1977.Google Scholar

Copyright information

© Springer-Verlag New York Inc. 1979

Authors and Affiliations

  • D. E. Harrison
  • L. E. Mobraaten

There are no affiliations available

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