Skip to main content
SpringerLink
Log in

Transplant Histocompatibility

  • Chapter
Manual of Renal Transplantation

Abstract

The main obstacle to successful organ transplantation is an incompatibility between recipient and donor for transplantation antigens. These foreign antigens on donor tissue can be recognized and reacted against by the recipient’s immune system; the result frequently is graft rejection. To counteract this problem, two approaches have been used clinically: matching for the known histocompatibility antigens and immunosuppression. If perfect, either one of these two approaches would permit successful renal transplantation. With the technique practiced today, a combination of both methods yields results that are clinically acceptable but far from perfect. The current status as well as future prospects will be discussed.

All animals are equal but some animals are more equal than others. George Orwell Animal Farm

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Abouna, G.M., Barabas, A.Z., Pazderka, V., Boyd, N., Vetters, J.M, Kinniburgh, D.W., Lao, V.S., Schlaut, J., Kovithavongs, T., and Dossetor, J.B.: Effect of pretreatment with multiple blood-transfusions and with skin grafts on the survival of renal allografts in mongrel dogs. Transplant. Proc. 9: 265, 1977.

    PubMed  CAS  Google Scholar 

  2. Arbeit, R.D., Sachs, D.H., Amos, D.B., and Dickler, H.B.; Human lymphocyte alloantigen(s) similar to murine Ir-region-associated (la) antigens. J. Immunol. 775: 1173, 1975.

    Google Scholar 

  3. Beizer, F.O., Perkins, H.A., Fortmann, J.L., Kountz, S.L., Salvatierra, O., Cochrum, K.D., and Payne, R.: Is HL-A typing of clinical significance in cadaver renal transplantation? Lancet 1: 774, 1974.

    Google Scholar 

  4. Berah, M., Hors, J., and Dausset, J.: A study of HL-A antigens in human organs. Transplantation 9: 185, 1970.

    Article  PubMed  CAS  Google Scholar 

  5. Brynger, H., Frisk, B., Ahlmen, J., Blohme, I., and Sandberg, L.: Blood transfusion and primary graft survival in male recipients. Scand. J. Urol. Nephrol. (Suppl.) 42: 76, 1977.

    Google Scholar 

  6. Cochrum, K.C., Perkins, H.A., Payne, R.O., Kountz, S.L., and Beizer, F.O.: The correlation of MLC with graft survival. Transplant. Proc. 5: 391, 1973.

    PubMed  CAS  Google Scholar 

  7. Dausset, J., Hors, J., Busson, M., Festenstein, H., Oliver, R.T.D., Paris, A.M.I., and Sachs, J A.: Serologically defined HL-A antigens and long-term survival of cadaver kidney transplants. N. Eng. J. Med. 290: 919, 1974.

    Article  Google Scholar 

  8. Festenstein, H., Sachs, J.A., Paris, A.M.I., Pegrum, G.D., and Moorhead, J.F.: Influence of HLA matching and blood transfusion on outcome of 502 London Transplant Group renal-graft recipients. Lancet 1: 157, 1976.

    Article  PubMed  CAS  Google Scholar 

  9. Festenstein, H., Sachs, J.A., Paris, A.M.I., Pegrum, G.D., and Moorhead, J.F.: Influence of HLA matching and blood transfusions on outcome of 502 London Transplant Group renal-graft recipients. Lancet 1: 157, 1976.

    Article  PubMed  CAS  Google Scholar 

  10. Fuller, T.C., Delmonico, F.L., Cosimi, A.B., Huggins, C.E., King, M., and Russell, P.S.: Effects of various types of RBC transfusions on HLA alloimmunization and renal allograft survival. Transplant. Proc. 9: 117, 1977.

    PubMed  CAS  Google Scholar 

  11. Halasz, N.A., Orloff, M.J., and Hirose, F.: Increased survival in renal homografts in dogs after injection of graft donor blood. Transplantation 2: 453, 1964.

    Article  PubMed  CAS  Google Scholar 

  12. Husberg, B., Lindergard, B., Lindholm, T., and Low, B.: Blood transfusion and kidney transplantation. Scand. J. Urol Nephrol. (Suppl.) 42: 73, 1977.

    Google Scholar 

  13. Jones, E.A., Goodfellow, P.N., Bodmer, J.G., and Bodmer, W.F.: Serological identification of HLA-Linked human “Ia-type” antigens. Nature 256: 650, 1975.

    Article  CAS  Google Scholar 

  14. Opelz, G. and Terasaki, P.I.: Prolongation effect of blood transfusions on kidney graft survival. Transplantation 22: 380, 1976.

    Article  PubMed  CAS  Google Scholar 

  15. Opelz, G. and Terasaki, P.I.: Significance of mixed leukocyte culture testing in cadaver kidney transplantation. Transplantation 32: 375, 1977.

    Article  Google Scholar 

  16. Opelz, G. and Terasaki, P.I.: HLA matching and cadaver kidney transplant survival in North America: Influence of center variation and presensitization. Transplantation 23: 490, 1977.

    Article  PubMed  CAS  Google Scholar 

  17. Opelz, G. and Terasaki, P.I.: Effect of blood-group on relation between HLA match and outcome of cadaver kidney transplants. Lancet 1: 220, 1977.

    Article  PubMed  CAS  Google Scholar 

  18. Opelz, G. and Terasaki, P.I.: Poor kidney transplant survival in recipients with frozen blood transfusions or no transfusions. Lancet 2: 696, 1974.

    Article  PubMed  CAS  Google Scholar 

  19. Opelz, G. and Terasaki, P.I.: Influence of sex on histocompatibility matching in renal transplantation. Lancet (In press).

    Google Scholar 

  20. Opelz, G., Mickey, M.R., and Terasaki, P.I.: Identification of unresponsive kidney transplant recipients. Lancet 1: 868, 1972.

    Article  PubMed  CAS  Google Scholar 

  21. Opelz, G., Mickey, M.R., and Terasaki, P.I.: Blood transfusions and unresponsiveness to HL-A. Transplantation 16: 649, 1973.

    Article  PubMed  CAS  Google Scholar 

  22. Oplez, G Sengar, D.P.S., Mickey, M.R., and Terasaki, P.I.: Effect of blood transfusions on subsequent kidney transplants. Transplant. Proc. 5: 253, 1973.

    Google Scholar 

  23. Persijn, G.G., van Hooff, J.P., Kalff, M.W., Lansbergen, Q., and van Rood, J.J.: The effect of blood transfusions and HLA matching on renal transplantation in the Netherlands. Transplant. Proc. 9: 503, 1977.

    PubMed  CAS  Google Scholar 

  24. Polesky, H.F., McCullough, J.J., Yunis, E.J., Helgeson, M.A., Anderson, R.C., Simmons, R.L., and Najarian, J.S.: Réévaluation of the effects of blood transfusions on renal graft survival. Transfusion 16: 536, 1976.

    Google Scholar 

  25. Safwenberg, J., Backman-Bave, U., and Hogman, C.: The effect of blood transfusions on cadaver kidney transplants—an analysis of patients transplanted in Uppsala. Scand. J. Urol. Nephrol. (Suppl.) 42: 59, 1977.

    Google Scholar 

  26. Scandiatransplant Report: HL-A matching and kidney graft survival. Lancet 1: 240, 1975.

    Google Scholar 

  27. Sirchia, G., Mercuriali, F., Scalamogna, M., Rosso di San Secondo, V., Pizzi, C., and Poli, F.: The cadaver kidney transplantation programme of Milano. Transplantation 23: 391, 1977.

    Article  PubMed  CAS  Google Scholar 

  28. Solheim, B.G., Engebretsen, T.E., Flatmark, A., Jervell, J., Enger, E., and Thorsby, E.: The influence of HLA-A, -B, -C and -D matching on kidney graft survival. Scand. J. Urol. Nephrol (Suppl.) 42: 28, 1977.

    Google Scholar 

  29. Solheim, B.G., Flatmark, A., Jervell, J., and Arnesen, E.: Influence of blood transfusions on kidney transplant and uremic patient survival. Scand. J. Urol. Nephrol. (Suppl.) 42: 65, 1977.

    Google Scholar 

  30. Terasaki, P.I. and McClelland, J.D.: Microdroplet assay of human serum cytotoxins. Nature 204: 998, 1964.

    Article  PubMed  CAS  Google Scholar 

  31. Terasaki, P.I., Opelz, G., Park, M.S., and Mickey, M.R.: Four new B lymphocyte specificities. In Histocompatibility Testing 1975 ( F. Kissmeyer-Nielsen, ed.). Munksgaard, Copenhagen, 1975, p. 657.

    Google Scholar 

  32. Ting, A., Mickey, M.R., and Terasaki, P.I.: B-lymphocyte alloantigens in Caucasians. J. Exp. Med. 745: 981, 1976.

    Article  Google Scholar 

  33. van Hooff, J.P., Schippers, H.M.A., van der Steen, G.J., and van Rood, J J.: Efficacy of HL-A matching in eurotransplant. Lancet 2: 1385, 1972.

    Article  PubMed  Google Scholar 

  34. van Es, A.A., Marquet, R.L., van Rood, J.J., Kalff, M.W., and Balner, H.: Blood-transfusions induce prolonged kidney allograft survival in rhesus monkeys. Lancet 1: 506, 1977.

    PubMed  Google Scholar 

  35. van Rood, J.J., van Leuwen, A., Keunig, J.J., and Blusse van Oud Alblas, A.: The serological recognition of the human MLC determinants using a modified cytotoxicity technique. Tissue Antigens 5: 73, 1975.

    Article  PubMed  Google Scholar 

  36. Walter, S., Poulsen, L.R., Friedberg, M., Afzelius, R., Federspiel, B.H., Larsen, H.W., and Petersen, K.: The effect of blood-transfusions on renal allograft survival. Scand. J. Urol. Nephrol. (Suppl.) 42: 62, 1977.

    Google Scholar 

  37. Winchester, R.J., Fu, S.M., Wernet, P., Kunkel, H.G., Dupont, B., and Jersild, C. Recognition by pregnancy serums of non-HLA alloantigens selectively expressed on B Lymphocytes. J. Exp. Med. 141: 924, 1975.

    PubMed  CAS  Google Scholar 

Download references

Authors
  1. Gerhard Opelz
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 1979 Springer-Verlag New York Inc.

About this chapter

Cite this chapter

Opelz, G. (1979). Transplant Histocompatibility. In: Manual of Renal Transplantation. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-6139-1_3

Download citation

  • DOI: https://doi.org/10.1007/978-1-4612-6139-1_3

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-6141-4

  • Online ISBN: 978-1-4612-6139-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation