Adaptive Regulation of Membrane Lipid Biosynthesis in Bacilli by Environmental Temperature

  • Armand J. Fulco
  • Dennis K. Fujii
Chapter
Part of the Experimental Biology and Medicine book series (EBAM, volume 1)

Abstract

Some years ago, when we decided to study lipid metabolism in bacilli, we did so with several objectives in mind. One goal was to determine the mechanisms by which bacilli adaptively adjust the composition of their membrane lipids in response to changes in environmental temperature. We found that temperature-mediated variations in bacilli membrane lipids could be conveniently divided into slow, long-term alterations that required growth and net lipid synthesis, and short-term alterations that were rapidly implemented in response to temperature changes and did not necessarily involve new lipid synthesis. Slow alterations included shifts in fatty acid chain length and branching, increases in saturated to unsaturated fatty acids ratios, and changes in phospholipids head-group distribution. Fast alterations included changes in the asymmetrical distribution of phospholipid types on the two sides of the membrane bilayer and decreases in the ratios of saturated to unsaturated fatty acids in these lipids.

Keywords

Attenuation Bacillus Oligomer Rifampicin Chloramphenicol 

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References

  1. Brown, N.C., C.L. Wisseman III, and T. Matsushita (1972). Nature New Biol., 237, 72.PubMedCrossRefGoogle Scholar
  2. Chang. N.C., and A.J. Fulco (1973). Biochim. Biophys. Acta,, 296, 287.Google Scholar
  3. Chen, S.L., and A.J. Fulco, (1978). Biochem. Biophys. Res. Commun., 80, 126PubMedCrossRefGoogle Scholar
  4. Chen, S.L., J.F., Lombradi, and A.J. Fulco (1978). Biochem. Biophys. Res. Commun., 80, 133.Google Scholar
  5. Fujii, D.K., and A.J. Fulco (1977). J. Biol. Chem., 252, 3660.PubMedGoogle Scholar
  6. Fulco, A.J., R. Levy, and K. Bloch (1964). J. Biol. Chem., 239, 998.PubMedGoogle Scholar
  7. Fulco, A.J. (1967). Biochim. Biophys. Acta, 144, 701.Google Scholar
  8. Fulco, A.J. (1969a). J. Biol. Chem., 244, 889Google Scholar
  9. Fulco, A.J. (1969b). Biochim. Biophys. Acta, 187, 169.Google Scholar
  10. Fulco, A.J. (1970). J. Biol. Chem. 245, 2985.Google Scholar
  11. Fulco, A.J. (1972a). J. Biol. Chem., 247, 3503.Google Scholar
  12. Fulco, A.J. (1972b) J. Biol. Chem., 247, 3511.Google Scholar
  13. Fulco, A.J. (1974). Annu. Rev. Biochem., 43, 215.Google Scholar
  14. Fulco, A.J. (1977). In W.H. Kumau and R.T. Holman (eds.), Polyunsaturated Fatty Acids. American Oil Chemists’ Society, Champaign, Illinois.Google Scholar
  15. Mead, J.F. and A.J. Fulco (1976). The Unsaturated and Polyunsaturated Fatty Acids in Health and Disease, Thomas, Springfield, Illinois, 191 pp.Google Scholar
  16. Quint, J.F., and A.J.Fulco (1973). J.Biol. Chem., 2448, 6885.Google Scholar

Copyright information

© The HUMANA Press Inc. 1980

Authors and Affiliations

  • Armand J. Fulco
    • 1
    • 2
  • Dennis K. Fujii
    • 1
    • 2
  1. 1.Department of Biological ChemistryUCLA Medical SchoolLos AngelesUSA
  2. 2.Laboratory of Nuclear MedicineUniversity of CaliforniaLos AngelesUSA

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