Regulation of Membrane Fluidity During Temperature Acclimation by TetrahymenaPyriformis
Nature seems to have chosen a variety of strategies for dealing with environmentally-induced perturbations of membrane fluidity. In recent years a number of investigators have examined the ability of the ciliated protozoan Tetrahymena pyriformis to offset the effects of extreme temperatures on membranes by altering its lipid composition. I should like to describe some of these observations, principally the ones made in my laboratory and the laboratory of Nozawa, which led us to believe that Tetrahymena, and perhaps many other organisms, respond to low temperature-induced suboptimal membrane fluidity by the same molecular sensing mechanism that they utilize for counteracting a variety of quite different fluidity-perturbing stimuli.
KeywordsCholesterol Deuterium Glutaraldehyde Phosphatidylcholine Phosphatidylethanolamine
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