Cancer Markers pp 169-190 | Cite as

Hormone-Secreting Tumors

  • George Griffing
  • Judith L. Vaitukaitis
Part of the Contemporary Biomedicine book series (CB, volume 1)

Abstract

Tumors may produce many classes of substances including hormones, enzymes, and biogenic amines. These substances are usually indistinguishable from their native counterparts and are normally synthesized and secreted in response to physiological stimuli. This discussion will focus on hormone-secreting tumors and their clinical presentations. For practical purposes, every hormone known to be physiologically secreted has been associated with ectopic tumor secretion. Peptide hormones are the most frequently produced ectopic hormones. Ectopic secretion of corticosteroids and thyroid hormones are extremely rare, probably because they require more sophisticated, compartmentalized enzymatic synthesis.

Keywords

Adenoma Cortisol Nicotine Polypeptide Prostaglandin 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Albright, F. (1941), New Engl. J. Med. 225, 789.CrossRefGoogle Scholar
  2. Azzopardi, J. G., and E. D. Williams (1968), Cancer 22, 274.PubMedCrossRefGoogle Scholar
  3. Bagshawe, K. D. (1960), Lancet 2, 284.PubMedCrossRefGoogle Scholar
  4. Bailey, R. E. (1971), J. Clin. Endocrinol. 32, 317.CrossRefGoogle Scholar
  5. Bartter, F. C., and W. B. Schwartz (1976), Amer. J. Med. 42, 790.CrossRefGoogle Scholar
  6. Baylin, S. B. (1972), Amer. J. Med. 53, 723.PubMedCrossRefGoogle Scholar
  7. Beck, C., and H. G. Burger (1972), Cancer 30, 75.PubMedCrossRefGoogle Scholar
  8. Bender, R. A., and H. Hansen (1974), Ann. Int. Med. 80, 2958.Google Scholar
  9. Bloom, S. R., J. M. Polak, and A. G. E. Pearse (1973), Lancet 2, 14.PubMedCrossRefGoogle Scholar
  10. Bloomfield, G. A., A. P. Scott, P. J. Lowry, J. J. H. Gilkes, and L. H. Rees (1974), Nature 252, 492.PubMedCrossRefGoogle Scholar
  11. Brown, W. H. (1928), Lancet 2, 1022.CrossRefGoogle Scholar
  12. Carey, R. M., D. N. Orth, and W. H. Hartmann (1973), J. Clin. Endocrinol. Metab. 36, 482.PubMedCrossRefGoogle Scholar
  13. Corrigan, D. F., M. Schaff, R. A. Whaley, C. L. Czerwinski, and J. M. Earll (1977), New Engl. J. Med. 296, 861.PubMedCrossRefGoogle Scholar
  14. Deftos, L. J., P. J. McMillan, G. P. Sartiano, J. Abuid, and A. G. Robinson (1976), Metabolism 25, 543.PubMedCrossRefGoogle Scholar
  15. DeTroyer, A., and J. C. Demanet (1976), Quart. J. Med. 45, 521.Google Scholar
  16. Dousa, T. P., and D. M. Wilson (1973), Curr. Ther. Res. 15, 734.Google Scholar
  17. Elias, E., S. R. Bloom, J. M. Polak, A. G. E. Pearse, R. B. Welbourn, C. C. Booth, M. Kuzio, and J. C. Brown (1972), Lancet 2, 791.PubMedCrossRefGoogle Scholar
  18. Ennis, G. C., D. P. Cameron, and H. G. Burger (1973), Austr. N. Z. J. Med. 3, 157.CrossRefGoogle Scholar
  19. Evans, D. J., and J. G. Azzopardi (1972), Lancet 1, 353.PubMedCrossRefGoogle Scholar
  20. George, J. M., C. C. Copen, and A. S. Phillips (1972), J. Clin. Invest. 51, 141.PubMedCrossRefGoogle Scholar
  21. Gerwitz, G., and R. S. Yalow (1974), J. Clin. Invest. 53, 1022.CrossRefGoogle Scholar
  22. Gerwitz, G., B. Schneider, D. T. Krieger, and R. S. Yalow (1974), J. Clin. Endocrinol. Metab. 38, 227.CrossRefGoogle Scholar
  23. Hamilton, B. P. M., G. B. Upton, and T. T. Amatruda (1972), J. Clin. Endocrinol. Metab. 35, 764.PubMedCrossRefGoogle Scholar
  24. Kaganowicz, A., N. H. Farkouh, A. G. Frantz, and A. U. Blaustein (1979), J. Clin. Endocrinol. Metab. 48, 5.PubMedCrossRefGoogle Scholar
  25. Kahn, R., A. G. Levy, J. D. Gardner, J. V. Miller, P. Gorden, and P. S. Schein (1975), New Engl. J. Med. 292, 941.PubMedCrossRefGoogle Scholar
  26. Kahn, R. C., S. W. Rosen, B. D. Weintraub, S. S. Fajans, P. Gorden (1977), New Engl. J. Med. 297, 565.PubMedCrossRefGoogle Scholar
  27. Kiang, D. T., G. E. Bauer, and B. J. Kennedy (1973), Cancer 31, 801.PubMedCrossRefGoogle Scholar
  28. Lange, P. H., K. R. Mclntire, T. A. Waldmann, T. R. Hakala, and E. E. Frawley (1976), New Engl. J. Med. 295, 1237.PubMedCrossRefGoogle Scholar
  29. Liddle, G. W., J. R. Givens, W. E. Nicholson, and D. P. Island (1965), Cancer Res. 25, 1957.Google Scholar
  30. Linn, J. E., Jr., B. Bowdoin, T. A. Farmer, and D. K. Meador (1967), New Engl. J. Med. 277, 403.PubMedCrossRefGoogle Scholar
  31. Lowry, P. J., L. H. Rees, S. Tomlin, G. Gillies, and J. Landon (1976), J. Clin. Endocrinol. Metab. 43, 831.PubMedCrossRefGoogle Scholar
  32. Mains, R. E., and B. A. Eipper (1976), J. Biol. Chem. 251, 4115.PubMedGoogle Scholar
  33. Mains, R., B. Eipper, and N. Ling (1977), Proc. Nat. Acad. Sei. USA 74, 3014.CrossRefGoogle Scholar
  34. McKenzie, C. G., I. M. A. Evans, C. J. Hillyard, P. Hill, S. Carter, M. K. Tan, and I. Maclntyre (1977), Brit. J. Cancer 36, 700.PubMedCrossRefGoogle Scholar
  35. Miura, K., C. Sasaki, I. Katsushima, T. Ohtomo, S. Sato, H. Demura, T. Torikai, and N. Sasano (1967), J. Clin. Endocrinol. 27, 631.CrossRefGoogle Scholar
  36. Odell, W. D. (1974), in Textbook of Endocrinology (R. H. Williams, ed.), 5th ed. Saunders, Philadelphia.Google Scholar
  37. Odell, W., A. Wolfsen, Y. Yoshimoto, R. Weitzman, D. Fisher, and H. Hirose (1977), Trans. Assoc. Amer. Phys. 90, 204.Google Scholar
  38. Pearse, A. G. E. (1969), J. Histochem. Cytochem. 17, 303.PubMedCrossRefGoogle Scholar
  39. Pearse, A. G. E. (1977), Med. Biol. 55, 115.PubMedGoogle Scholar
  40. Rees, L. H. (1978), in Biological Markers of Neoplasia: Basic and Applied Aspects (R. W. Ruddon, ed.)., Elsevier/North-Holland, New York.Google Scholar
  41. Riggs, L., C. D. Arnaud, J. C. Reynolds, and L. H. Smith (1971), J. Clin. Invest. 50, 2079.PubMedCrossRefGoogle Scholar
  42. Said, S. I., and G. R. Faloona (1975), New Engl. J. Med. 293, 155.PubMedCrossRefGoogle Scholar
  43. Samaan, N. A., R. C. Hickey, C. S. Hill, Jr., H. Medellin, and R. B. Gates (1974), Cancer 33, 933.PubMedCrossRefGoogle Scholar
  44. Samaan, N. A., R. C. Hickey, M. R. Sethi, K. P. Yang, and S. Wallace (1976), Surgery 80, 382.PubMedGoogle Scholar
  45. Schein, P. S., R. A. DeLillis, C. R. Kahn, P. Görden, and A. R. Kraft (1973), Ann. Int. Med. 79, 239.PubMedGoogle Scholar
  46. Schumacher, H. R., Jr. (1976), Arth. Rheumatol. 19, 629.CrossRefGoogle Scholar
  47. Schwartz, C. J., D. V. Kimberg, H. E. Sheerin, M. Field, and S. I. Said (1974), J. Clin. Invest. 54, 536.PubMedCrossRefGoogle Scholar
  48. Shield, C. F., III, and R. C. Hoff (1976), Amer. J. Surg. 132, 784.PubMedCrossRefGoogle Scholar
  49. Silva, O. L., and K. L. Becker (1978), in Biological Markers of Neoplasia: Basic and Applied Aspects (R. W. Ruddon, ed.), Elsevier/North- Holland, New York.Google Scholar
  50. Silva, O. L., K. L. Becker, A. Primack, J. L. Doppman, and R. H. Snider (1975), JAMA 234, 184.CrossRefGoogle Scholar
  51. Sparagana, M., G. Phillips, C. Hoffman, and L. Kucera (1971), Metabolism 20, 730.PubMedCrossRefGoogle Scholar
  52. Suda, T., H. Demura, R. Demura, I. Wakabayashi, K. Nomura, E. Odagiri, and K. Shizume (1977), J. Clin. Endocrinol. Metab. 44, 440.PubMedCrossRefGoogle Scholar
  53. Suki, W. N., J. J. Yium, M. VonMinden, C. Sailer-Herbert, G. Eknoyan, and M. Martinez-Maidonado (1970), New Engl. J. Med. 283, 836.PubMedCrossRefGoogle Scholar
  54. Thomas, A. N., H. F. Loken, G. S. Gordan, L. Goldman (1960), Surg. Forum 11, 70.PubMedGoogle Scholar
  55. Unger, R. H. (1966), Amer. J. Med. 40, 352.CrossRefGoogle Scholar
  56. Unger, R. H., J. Lochner, A. M. Eisentraut (1964), J. Clin. Endocrinol. Metab. 24, 823.PubMedCrossRefGoogle Scholar
  57. Upton, V. G., and T. T. Amatruda (1971), New Engl. J. Med. 285, 419.PubMedCrossRefGoogle Scholar
  58. Vaitukaitis, J. L., and E. R. Ebersole (1976), J. Clin. Endocrinol. Metab. 42, 1048.PubMedCrossRefGoogle Scholar
  59. Vaitukaitis, J. L., G. D. Braunstein, and G. T. Ross (1972), Am. J. Obstet. Gynecol. 113, 751.PubMedGoogle Scholar
  60. Vaitukaitis, J. L., G. T. Ross, G. D. Braunstein, and P. L. Rayford (1976), Rec. Prog. Horm. Res. 32, 289.PubMedGoogle Scholar
  61. Verner, J. V., Jr., and A. B. Morrison (1958), Amer. J. Med. 374, 1958.Google Scholar
  62. Vingerholds, A. C. M., P. J. der Kinderen, J. H. H. Thijssen, and F. Schwarz (1971), Acta Endocrinol. 67, 625.Google Scholar
  63. Vorherr, H., S. G. Mossry, R. D. Utiger, and C. J. Kleeman (1968), J. Clin. Endocrinol. 28, 162.CrossRefGoogle Scholar
  64. Warwick, O. H., E. R. Yendt, and J. S. Olin (1961), Canad. Med. J. 85, 719.Google Scholar
  65. Winkler, A. W., and O. F. Crankshaw (1938), J. Clin. Invest. 17, 1.PubMedCrossRefGoogle Scholar
  66. Yalow, R. S., and S. A. Berson (1973), J. Clin. Endocrinol. Metabi. 36, 415.CrossRefGoogle Scholar
  67. Zilva, J. F., and J. P. Nicholson (1973), J. Clin. Endocrinol. Metab. 36, 1019.PubMedCrossRefGoogle Scholar

Copyright information

© The HUMANA Press Inc. 1980

Authors and Affiliations

  • George Griffing
    • 1
    • 2
  • Judith L. Vaitukaitis
    • 1
    • 2
  1. 1.Section of Endocrinology and Metabolism, Thorndike Memorial LaboratoryBoston City HospitalBostonUSA
  2. 2.Department of MedicineBoston University School of MedicineBostonUSA

Personalised recommendations