Tumors may produce many classes of substances including hormones, enzymes, and biogenic amines. These substances are usually indistinguishable from their native counterparts and are normally synthesized and secreted in response to physiological stimuli. This discussion will focus on hormone-secreting tumors and their clinical presentations. For practical purposes, every hormone known to be physiologically secreted has been associated with ectopic tumor secretion. Peptide hormones are the most frequently produced ectopic hormones. Ectopic secretion of corticosteroids and thyroid hormones are extremely rare, probably because they require more sophisticated, compartmentalized enzymatic synthesis.
KeywordsAdenoma Cortisol Nicotine Polypeptide Prostaglandin
Unable to display preview. Download preview PDF.
- Bender, R. A., and H. Hansen (1974), Ann. Int. Med. 80, 2958.Google Scholar
- DeTroyer, A., and J. C. Demanet (1976), Quart. J. Med. 45, 521.Google Scholar
- Dousa, T. P., and D. M. Wilson (1973), Curr. Ther. Res. 15, 734.Google Scholar
- Liddle, G. W., J. R. Givens, W. E. Nicholson, and D. P. Island (1965), Cancer Res. 25, 1957.Google Scholar
- Odell, W. D. (1974), in Textbook of Endocrinology (R. H. Williams, ed.), 5th ed. Saunders, Philadelphia.Google Scholar
- Odell, W., A. Wolfsen, Y. Yoshimoto, R. Weitzman, D. Fisher, and H. Hirose (1977), Trans. Assoc. Amer. Phys. 90, 204.Google Scholar
- Rees, L. H. (1978), in Biological Markers of Neoplasia: Basic and Applied Aspects (R. W. Ruddon, ed.)., Elsevier/North-Holland, New York.Google Scholar
- Silva, O. L., and K. L. Becker (1978), in Biological Markers of Neoplasia: Basic and Applied Aspects (R. W. Ruddon, ed.), Elsevier/North- Holland, New York.Google Scholar
- Verner, J. V., Jr., and A. B. Morrison (1958), Amer. J. Med. 374, 1958.Google Scholar
- Vingerholds, A. C. M., P. J. der Kinderen, J. H. H. Thijssen, and F. Schwarz (1971), Acta Endocrinol. 67, 625.Google Scholar
- Warwick, O. H., E. R. Yendt, and J. S. Olin (1961), Canad. Med. J. 85, 719.Google Scholar