Carcinoembryonic Antigen A: Chemistry and Biology

Shively, John E.; Todd, Charles W.

doi:10.1007/978-1-4612-6117-9_11

John E. Shively³ &
Charles W. Todd³

Part of the book series: Contemporary Biomedicine ((CB,volume 1))

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15 Citations

Abstract

Carcinoembryonic antigen (CEA) is a high-molecular-weight, cell-surface glycoprotein usually associated with tumors of the human colon. It was first described by Gold and Freedman (1965b) as a component of human colon carcinoma and fetal colon tissue. Although early studies suggested that elevated serum levels of CEA may be diagnostic of colonic cancer, subsequent studies showed that CEA may be elevated in other types of cancer and in various inflammatory diseases. The diagnostic significance of various CEA immunoassays has led to intensive research into the biology and chemistry of CEA. As a result of these studies, CEA is one of the most highly characterized human tumor markers.

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City of Hope National Medical Center, Duarte, California, USA
John E. Shively & Charles W. Todd

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John E. Shively
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Department of Pathology, University of California Medical School, San Diego, La Jolla, California, USA
Stewart Sell

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Shively, J.E., Todd, C.W. (1980). Carcinoembryonic Antigen A: Chemistry and Biology. In: Sell, S. (eds) Cancer Markers. Contemporary Biomedicine, vol 1. Humana Press. https://doi.org/10.1007/978-1-4612-6117-9_11

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DOI: https://doi.org/10.1007/978-1-4612-6117-9_11
Publisher Name: Humana Press
Print ISBN: 978-1-4612-6119-3
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