Abstract
Since the industrial revolution, and especially during this century, man and his environment have been exposed to an ever-increasing number of synthetic organic compounds. In many cases the compounds produced by our techology are, in a biological sense, “foreign chemicals” or “xenobiotics.” That is, they are not synthesized by any known biological systems. The use of many of these compounds, which include a variety of drugs and pesticides, has had positive and far-reaching effects, both socially and economically. However, use of some of these foreign chemicals has had unexpected and, in some cases, undesirable effects. The awareness that the production and use of these compounds may have adverse effects on man and the environment has generated a great deal of interest concerning the fate of these compounds in biological systems. Because of this interest and because of the efforts of many investigators (particularly during the past 2 decades) there is now a large amount of published information concerning the metabolic fate of foreign chemicals in animals, including man (Fishman 1970; Lee et al. 1977; Williams 1947, 1959, and 1967; Hathway 1970, 1972, and 1975; Ladu et al. 1971; Parke 1968; Brodie and Gillette 1971; Parke and Smith 1977).
Metabolism and Radiation Research Laboratory, Agricultural Research, Science and Education Administration, U. S. Department of Agriculture, Fargo, ND 58105. Mention of a trademark or proprietary product does not constitute a guarantee or warranty by the U. S. Department of Agriculture and does not imply its approval to the exclusion of other products that may be suitable.
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Paulson, G.D. (1980). Conjugation of foreign chemicals by animals. In: Gunther, F.A., Gunther, J.D. (eds) Residue Reviews. Residue Reviews, vol 76. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-6107-0_2
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