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Minimizing occupational exposure to pesticides: Recent developments in methodology for monitoring pesticide metabolites in human urine

  • D. E. Bradway
  • E. M. Lores
  • T. R. Edgerton
Part of the Residue Reviews book series (RECT, volume 75)

Abstract

A big percentage of the chemicals encountered in the environment are eventually excreted in the urine as various polar metabolites. Therefore, indices of exposure to these compounds may be established by monitoring levels of urinary metabolites. Since many of the metabolites may be classified into one of several broad categories (i.e., phenols, anilines, alkyl phosphates, etc.) a few basic methods permit the monitoring of a large number of metabolites.

Keywords

High Performance Liquid Chromatography High Performance Liquid Chromatography Human Urine Organophosphorus Pesticide Triazine Herbicide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Bradway, D. E., and R. F. Moseman: The determination of urinary residue levels of the N-dealkyl metabolites of triazine herbicides. In manuscript (1980).Google Scholar
  2. Bradway, T. M. Shafik, and E. M. Lores: Comparison of Cholinesterase activity, residue levels, and urinary metabolite excretion of rats exposed to organophosphorus pesticides. J. Agr. Food Chem. 25, 1353 (1977).CrossRefGoogle Scholar
  3. Brotell, H., H. Ehrsson, and O. Gyllenhaal: Gas chromatographic determination of pentazocine in human plasma by means of electron capture detection. J. Chromatogr. 78, 293 (1973).PubMedGoogle Scholar
  4. De Silva, J. A. F., I. Bekersky, C. V. Puglisi, M. A. Brooks, and R. E. Weinfeld: Determination of 1,4-benzodiazepines and diazepin-2-ones in blood by electron-capture gas-liquid chromatography. Anal. Chem. 48, 10 (1976).PubMedCrossRefGoogle Scholar
  5. Edgerton, T. R., and R. F. Moseman: Determination of pentachlorophenol in urine: The importance of hydrolysis. J. Agr. Food Chem. 27, 197 (1979).CrossRefGoogle Scholar
  6. Edgerton, T. R., and R. F. Moseman: Gas chromatography of underivatized chlorinated phenols on support bonded polyester column packing. J. Chrom. Sci. 18, 25 (1980).Google Scholar
  7. Edgerton, E. M. Lores, and L. H. Wright: Isolation and gas chromatography of trace quantities of chlorinated free phenols in human urine. Submitted J. Chromatogr. (1980).Google Scholar
  8. Ehrsson, H.: Gas chromatographic determination of barbiturates after extractive methylation in carbon disulfide. Anal. Chem. 46, 922 (1974).PubMedCrossRefGoogle Scholar
  9. Gyllenhaal, O., and H. Ehrsson: Determination of sulfonamides by electron-capture gas chromatography. Preparation and properties of pentafluoroacyl and penta-fluorobenzyl derivatives. J. Chromatogr. 107, 327 (1975).PubMedCrossRefGoogle Scholar
  10. Lores, E. M., and D. E. Bradway: Extraction and recovery of organophosphorusGoogle Scholar
  11. metabolites from urine using an anion exchange resin. J. Agr. Food Chem. 25, 75(1977).Google Scholar
  12. Moseman, R. F.: A rapid procedure for preparation of support bonded carbowax 20M GC column packing. J. Chromatogr. 166, 397 (1978).CrossRefGoogle Scholar
  13. Shaftik, M. T., D. Bradway, F. Brnos, and H. Enos: Characterization of alkylation products of diethyl phosphorothioate. J. Agr. Food Chem. 18, 1174 (1970).CrossRefGoogle Scholar
  14. Shaftik, H. F. Enos, and A. R. Yobs: Human exposure to organophosphorus pesticides. A modified procedure for the gas-liquid chromatographic analysis of alkyl phosphate metabolites in urine. J. Agr. Food Chem. 21, 625 (1973).CrossRefGoogle Scholar

Copyright information

© Springer-Verlag New York Inc. 1980

Authors and Affiliations

  • D. E. Bradway
    • 1
  • E. M. Lores
    • 1
  • T. R. Edgerton
    • 1
  1. 1.Environmental Toxicology Division, Health Effects Research LaboratoryU.S. Environmental Protection AgencyUSA

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