The Quantitative Assessment of the Effect of Antiplatelet Drugs on Thrombosis in Microvascular Anastomoses

  • G. G. Ferguson
  • M. L. Bream
  • R. B. Philp

Abstract

The effect of various antiplatelet drugs on the patency of micro vascular anastomoses in a laboratory model using the rat has been studied. The objectives were threefold: (1) to test the usefulness of micro vascular anastomosis as an animal model of thrombosis, as no entirely satisfactory model exists,1 (2) to develop a quantitative measure of thrombosis with which to compare the ant thrombus activity of the drugs, as considerable controversy exists on the basis of prior model experiments and clinical trials as to their efficacy,2 and (3) to determine if enhanced micro vascular patency was possible using single intravenous bolus injection of the drugs during the anastomosis procedure itself.

Keywords

Formalin Ischemia Polyethylene Glycol Aspirin 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Didisheim, P. Animal models useful in the study of thrombosis and anti-thrombotic agents. Prog Hemost Thromb 1: 165–179, 1972.PubMedGoogle Scholar
  2. 2.
    Gallus, A.S., Hirsh, J. Anti-thrombotic drugs: Part II. Drugs 12: 132–157, 1976.Google Scholar
  3. 3.
    Rosenbaum, T.J., Sundt, T.M. Thrombus formation and endothelial alterations in microarterial anastomoses. J Neurosurg 47: 430–441, 1977.PubMedCrossRefGoogle Scholar
  4. 4.
    Sundt, T.M., Siekert, R.G., Piepgras, D.G., Sharbrough, F.W., Houser, O.W. Bypass surgery for vascular disease of the carotid system. Mayo Clin Proc 51: 677–692, 1976.PubMedGoogle Scholar

Copyright information

© Springer-Verlag New York Inc. 1980

Authors and Affiliations

  • G. G. Ferguson
  • M. L. Bream
  • R. B. Philp

There are no affiliations available

Personalised recommendations