Abstract
The goal of our investigative efforts has been to develop an objective means by which ischemic infarction of brain tissue can be promptly and reliably detected and the volume of infarcted tissue can be usefully estimated. The precedent for our investigations stems from the significant role that isoenzyme determination has had in the evaluation of myocardial ischemia and infarction and arises directly from the work of two investigators at our institution6 who developed the radioimmunoassay technique for the delineation of the brain-specific isoenzyme creatine phosphokinase BB (CK-BB). Utilizing these two investigators’ radioimmunoassay technique with their assistance and encouragement, we have attempted to apply this method of quantification to a canine experimental stroke model.
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References
Little, D.R., 1977. Implanted device for middle cerebral artery occlusion in conscious cats. Stroke 8: 258–260.
Molinari, G.S., Laurent, J.P.,1977. A classification of experimental models of brain ischemia. Stroke 70: 14–17.
Redmond, D.E., Jr., RinderKnecht, H.R., Hudgins, P.J., 1970. A technique for repeated access to the subarachnoid space in the dog. J Neurosurg 33: 74.
Oakes, W.J., Kramer, R.S. Unpublished data.
Waltz, A.G., Sundt, T.M.,1967. The microvasculative and microcirculation of the cerebral cortex after arterial occlusion. Brain 90: 681–697.
Willerson, J.T., Stone, M.J., Ting, R., Mukherjee, A., Gomez-Sanchez, C.E., Lewis, P., Hersh, L.P., 1977. Radioimmunoassay of CPK-B isoenzyme in human sera: Results in patients with acute myocardial infarction. Proc Nat Acad Sci 74: 1711–1715.
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Samson, D.S., Beyer, C.W., Bell, R., Mayhood, M. (1980). Serum and CSF Brain-Specific Isoenzyme Profiles in Experimental Cerebral Ischemia and Infarction. In: Peerless, S.J., McCormick, C.W. (eds) Microsurgery for Cerebral Ischemia. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-6090-5_3
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DOI: https://doi.org/10.1007/978-1-4612-6090-5_3
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