Role of Erythrocyte Carbonic Anhydrase in Oxygen Delivery to Brain

Raichle, M. E.; Laux, B. E.

doi:10.1007/978-1-4612-6090-5_1

M. E. Raichle &
B. E. Laux

54 Accesses

Abstract

The brain is critically dependent for its moment-to-moment function and survival on an adequate supply of oxygen. Because the amount of oxygen stored within the tissue is low, factors concerned with oxygen availability become of paramount importance. These factors include an adequate and responsive blood supply, an adequate oxygen-carrying capacity of the blood, and adequate oxygenation of circulating blood. It is, indeed, the purpose of this conference to focus on the first of these factors, namely, local derangements of cerebral blood flow (CBF) caused by narrowing or occlusion of major cerebral blood vessels.

This work was supported by U.S. Public Health Service Grants 5 P01 HL 13851 and 5 P50 NS 06833.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Chapter: USD 29.95; Price excludes VAT (USA)

eBook: USD 39.99; Price excludes VAT (USA)

Softcover Book: USD 54.99; Price excludes VAT (USA)

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Reference

Cotev, S., Lee, J., Severinghaus, J.W. 1968 The effects of acetazolamide on cerebral blood flow and cerebral issue pO2.. Anesthesiology 29: 471–477.
Article PubMed CAS Google Scholar
Forster, R.E., Crandall, E.D. 1975. Time course of ex-changes between red cells and extracellular fluid during CO2 uptake. J Appl Physiol 38:710–718
PubMed CAS Google Scholar
Maren, T.H. 1967. Use of inhibitors in physiological studies of carbonic anhydrase. Am J Physiol. 232 (4): F291–F297.
Google Scholar
Raichle, M.E., Eichling, J.O., Straatmann, M.G., Welch, M.J., Larson, K.B., Ter-Pogossian, M.M. 1976. Blood-brain barrier permeability of ¹¹C-labeled alcohols and ¹⁵O-labeled water. Am J Physiol. 230: 543–552.
PubMed CAS Google Scholar
Roth, L.J., Schoolar, J.C., Barlow, C.F. 1959. Sulfur-35 labeled acetazolamide in cat brain. J Pharmacol Exp Ther 125: 128–136.
Google Scholar
Welch, M.J., Ter-Pogossian, M.M. 1968. Preparation of short half-lived radioactive gases for medical studies. Radiat Res 36: 580–587.
Article PubMed CAS Google Scholar

Download references

Authors

M. E. Raichle
View author publications
You can also search for this author in PubMed Google Scholar
B. E. Laux
View author publications
You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

University of Western Ontario, London, Ontario, Canada
S. J. Peerless M.D., F.R.C.S.(C) (Professor of Neurosurgery, Chairman) (Professor of Neurosurgery, Chairman)
Division of Neurosurgery, Department of Clinical Neurological Sciences, University Hospital, London, Ontario, Canada
S. J. Peerless M.D., F.R.C.S.(C) (Professor of Neurosurgery, Chairman) (Professor of Neurosurgery, Chairman)
Department of Clinical Neurological Sciences, University Hospital, London, Ontario, Canada
C. W. McCormick M.D.,F.R.C.P.(C) (Assistant Professor of Neurology) (Assistant Professor of Neurology)

Rights and permissions

Reprints and permissions

Copyright information

About this chapter

Cite this chapter

Raichle, M.E., Laux, B.E. (1980). Role of Erythrocyte Carbonic Anhydrase in Oxygen Delivery to Brain. In: Peerless, S.J., McCormick, C.W. (eds) Microsurgery for Cerebral Ischemia. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-6090-5_1

Download citation

DOI: https://doi.org/10.1007/978-1-4612-6090-5_1
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4612-6092-9
Online ISBN: 978-1-4612-6090-5
eBook Packages: Springer Book Archive

Publish with us

Policies and ethics