Role of HDL in Individual Prediction and Community Prevention of Coronary Heart Disease

  • Frederick H. Epstein
Conference paper


It is likely, depending on age and still limited information, that high-density lipoprotein (HDL) levels predict coronary heart disease (CHD) risk probably as well and possibly better than total serum cholesterol (TSC) and, certainly, that their combination permits more powerful prediction than either measurement alone (Kannel et al. 1979). The correlation between TSC and low-density lipoprotein (LDL) is very high so that TSC level measures the atherogenic potential of LDL. Since there is also much evidence that HDL is causally related to atherosclerosis as a protective factor, the balance of LDL and HDL as reflected by their serum levels is likely to be a key element in atherosclerosis prevention.


Coronary Heart Disease Coronary Heart Disease Risk Total Serum Cholesterol Coronary Heart Disease Event Total Serum Cholesterol Level 
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  1. Coronary Risk Handbook using HDL-Cholesterol for Persons over 50. From the Framingham Study: W.B. Kannel, M.D., Director, May 1978Google Scholar
  2. Epstein FH (1973) Coronary heart disease epidemiology revisited: clinical and community aspects. Circulation 48: 185–194PubMedGoogle Scholar
  3. Epstein FH (in press) Myocardial infarction in Europe. In: International Meeting on Myocardial Infarction (G.G. Neri Serneri, ed.) Excerpta Medica Publ., AmsterdamGoogle Scholar
  4. Kannel WB, Castelli WP and Gordo T (1979) Cholesterol in the prediction of atherosclerotic disease. Ann Int Med 90: 85–91PubMedGoogle Scholar
  5. Pooling Project Research Group (1978) Relationship of blood pressure, serum cholesterol, smoking habit, relative weight and ECG abnormalities to incidence of major coronary events. J Chronic Dis 31: 201–306CrossRefGoogle Scholar
  6. Proceedings of the Conference on the Decline in Coronary Heart Disease Mortality (1979) (RJ Havlik and M Feinleib eds) US Dept of HEW, Public Health Service, Nat.Inst. of Health, NIH Publ. No. 79-1610Google Scholar
  7. Rifkind BM, Tamir I, Heiss G, Wallace RB and Tyroler HA (1979) Distribution of high density and other lipoproteins in selected LRC prevalence study populations: a brief survey. Lipids 14: 105–112PubMedCrossRefGoogle Scholar
  8. Srinivasan SR, Frerichs RR, Webber LS and Berenson GS (1979) Serum lipid profile in children from a biracial community. Circulation 54: 309–318Google Scholar
  9. Tyroler HA, Harnes CG, Krishan I, Heyden S, Cooper G and Cassel JC (1975) Black-white differences in serum lipids and lipoproteins in Evans County. Prevent Med 4: 541–549CrossRefGoogle Scholar

Copyright information

© Springer-Verlag New York Inc. 1980

Authors and Affiliations

  • Frederick H. Epstein

There are no affiliations available

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